Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Nikola Lepse"'
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Toll-like receptor 9 activation enhances B cell activating factor and interleukin-21 induced anti-proteinase 3 autoantibody production in vitro
Autor: Coen A. Stegeman, Wayel H. Abdulahad, Cees G. M. Kallenberg, Peter Heeringa, Nikola Lepse, Judith Land, Abraham Rutgers
Publikováno v: Rheumatology, 55(1), 162-172. Oxford University Press
Objectives. Granulomatosis with polyangiitis (GPA) is a relapsing small-vessel vasculitis characterized by circulating ANCA against PR3. The mechanisms that trigger PR3-ANCA production are unknown. The aim of this study was to determine whether endog
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a60ca7fcd2b36bea8f37a98303287824
https://research.rug.nl/en/publications/8380d7f9-d58b-4908-bdb5-67c58ab0eb27
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3
Immune regulatory mechanisms in ANCA-associated vasculitides
Autor: Peter Heeringa, Wayel H. Abdulahad, Cees G. M. Kallenberg, Nikola Lepse
Publikováno v: Autoimmunity reviews. 11(2):77-83
A group of primary vasculitides is associated with the presence of anti-neutrophil cytoplasmic autoantibodies (ANCA). In these diseases, the contribution of ANCA to disease pathogenesis has been studied extensively. Also, in patients with ANCA-associ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f08748d586dee7eaf25ff37747fd4864
https://doi.org/10.1016/j.autrev.2011.08.002
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4
Bacterial DNA motifs trigger ANCA production in ANCA-associated vasculitis in remission
Autor: Cees G. M. Kallenberg, Peter Heeringa, Wayel H. Abdulahad, Henko Tadema, Coen A. Stegeman, Nikola Lepse
Publikováno v: Rheumatology, 50(4), 689-696. Oxford University Press
Objectives. CpG motifs, which are highly prevalent in bacterial DNA, have been shown to trigger the production of ANCA in vitro by B lymphocytes from patients with active ANCA-associated vasculitis (AAV). Staphylococcus aureus is associated with rela
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9ab9f9c588399dc844579b2133bc1f5
https://doi.org/10.1093/rheumatology/keq375
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5
Altered B cell balance, but unaffected B cell capacity to limit monocyte activation in anti-neutrophil cytoplasmic antibody-associated vasculitis in remission
Autor: Peter Heeringa, Coen A. Stegeman, Cees G. M. Kallenberg, Abraham Rutgers, Nikola Lepse, Wayel H. Abdulahad
Publikováno v: Rheumatology, 53(9), 1683-1692. Oxford University Press
OBJECTIVE: Regulatory B cells (Bregs) constitute a subset of B cells with immunomodulatory properties. Numerical and functional alterations in the Breg compartment have been associated with autoimmunity. The aim of this study was to assess the freque
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::823f9aad3967438a54289332c2c59115
https://research.rug.nl/en/publications/5f59ed08-1ebb-42e2-9f2a-61a06ba4d9aa
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8
Increased frequency of circulating IL-21 producing Th-cells in patients with granulomatosis with polyangiitis (GPA)
Autor: Pieter C. Limburg, Peter Heeringa, Cees G. M. Kallenberg, Wayel H. Abdulahad, Minke G. Huitema, Abraham Rutgers, Henko Tadema, Berber Doornbos-van der Meer, Nikola Lepse, Coen A. Stegeman
Publikováno v: Arthritis Research & Therapy; Vol 15
Arthritis Research and Therapy, 15(3):70. BioMed Central Ltd.
Arthritis Research & Therapy
INTRODUCTION: The present study aimed to explore a possible role for IL-21 producing Th-cells in the immunopathogenesis of granulomatosis with polyangiitis (GPA).METHODS: Peripheral blood from 42 GPA patients in remission and 29 age-matched healthy c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1f41194bd3f7f1e65919376bf92392d
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