Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Nikol Sullo"'
Autor:
Simon Wheeler, Per Haberkant, Meenakshi Bhardwaj, Paige Tongue, Maria J. Ferraz, David Halter, Hein Sprong, Ralf Schmid, Johannes M.F.G. Aerts, Nikol Sullo, Dan J. Sillence
Publikováno v:
Neurobiology of Disease, Vol 127, Iss , Pp 242-252 (2019)
Niemann-Pick type C disease (NPCD) is a neurodegenerative disease associated with increases in cellular cholesterol and glycolipids and most commonly caused by defective NPC1, a late endosomal protein. Using ratiometric probes we find that NPCD cells
Externí odkaz:
https://doaj.org/article/6fb5ca776cce47189af2095afd786cce
Publikováno v:
Therapeutic Advances in Respiratory Disease, Vol 2 (2008)
Lung injuries are leading causes of morbidity and mortality worldwide. Pulmonary diseases such as asthma or chronic obstructive pulmonary disease characterized by loss of lung elasticity, small airway tethers, and luminal obstruction with inflammator
Externí odkaz:
https://doaj.org/article/af44c64e479d4cc88d5a5b809b286560
Autor:
Kiara Abayasekara, Nikol Sullo
Publikováno v:
Clinical and experimental pharmacologyphysiology.
Acute Kidney Injury (AKI) affects 47% of Adult Surgical Critical Care Patients (ASCCPs). AKI is induced through a common oxidative stress pathway resulting in mitochondrial and tubular cell injury with increased urinary mitochondrial DNA (UmtDNA) exc
Autor:
Marcin J Woźniak, Attilio A. Lotto, Lathishia Joel-David, Claire Westrope, Gavin J. Murphy, Tracy Kumar, Paolo Pais, Dawn T. Smallwood, Maria JnTala, Bryony Eagle Hemming, Nikol Sullo, Lorenzo Grazioli, Florence Lai, Claudio Corazzari, Simon Robinson, Gavin Majithia-Beet
Publikováno v:
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 21(4)
Objectives Extracorporeal membrane oxygenation is a treatment for Persistent Pulmonary Hypertension of the Newborn with high mortality. Hypothesis the extracorporeal membrane oxygenation circuit results in inflammatory responses that mitigate against
Autor:
S K Bhudia, Rebecca Cardigan, Marcin Wozniak, Tom Morris, N. Bittar, Tracy Kumar, Saqib Qureshi, Mintu Nath, Nikol Sullo, Alison H. Goodall, Gavin J. Murphy, William Dott, M Wiltshire
Publikováno v:
BJA: British Journal of Anaesthesia
Background Experimental studies suggest that mechanical cell washing to remove pro-inflammatory components that accumulate in the supernatant of stored donor red blood cells (RBCs) might reduce inflammation and organ injury in transfused patients. Me
Autor:
David Halter, Johannes M. F. G. Aerts, Daniel J. Sillence, Hein Sprong, Maria J. Ferraz, Meenakshi Bhardwaj, Per Haberkant, Simon Wheeler, Ralf Schmid, Paige Tongue, Nikol Sullo
Publikováno v:
Neurobiology of Disease, Vol 127, Iss, Pp 242-252 (2019)
A new paradigm for Niemann-Pick C disease is presented where lysosomal storage leads to a deficit in cytoplasmic glucosylceramide (GlcCer) where it performs important functions. Previously it had been reported that Gaucher cells have defective endoly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfc20e61e0a111f8fd0b3a459259b6fa
http://hdl.handle.net/10029/622921
http://hdl.handle.net/10029/622921
Autor:
Bruno D'Agostino, Ruth Saunders, Konrad Urbanek, Giuseppe Spaziano, Francesco Rossi, Raffaele De Palma, David G. Lambert, Girolamo Calo, Mitesh Pancholi, Remo Guerrini, Antonella De Angelis, Lucy Woodman, Vijay Mistry, John McDonald, Maria Matteis, Christopher E. Brightling, Rachid Berair, Shailendra Singh, Nikol Sullo
Publikováno v:
British Journal of Pharmacology. 173:1286-1301
Background and Purpose There is evidence supporting a role for the nociceptin/orphanin FQ (N/OFQ; NOP) receptor and its endogenous ligand N/OFQ in the modulation of neurogenic inflammation, airway tone and calibre. We hypothesized that NOP receptor a
Autor:
Paolo Pais, Claire Westrope, Dawn T. Smallwood, Attilio A. Lotto, Marcin J Woźniak, Silvia Mariani, Nikol Sullo, Tracy Kumar, Gavin J. Murphy, Maria JnTala
The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link. Objectives: Micro-RNA, small noncoding RNA fragments involved in gene regulation, and microvesicles, m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64bb336660871869328f694f79b24986
https://doi.org/10.1097/pcc.0000000000001604
https://doi.org/10.1097/pcc.0000000000001604
Autor:
Gavin J. Murphy, Tracy Kumar, Alison H. Goodall, Nikol Sullo, Mintu Nath, William Dott, Rebecca Cardigan, Michael Wiltshire, Saqib Qureshi, Marcin J Woźniak, Nishith N. Patel
Publikováno v:
Anesthesiology. 128(2)
Background We evaluated the effects of two interventions that modify the red cell storage lesion on kidney and lung injury in experimental models of transfusion. Methods White–landrace pigs (n = 32) were allocated to receive sham transfusion (cryst
Publikováno v:
Peptides. 39:36-46
The heptadecapeptide nociceptin/orphanin FQ (N/OFQ) is the endogenous ligand for the N/OFQ peptide (NOP) receptor. It is cleaved from a larger precursor identified as prepronociceptin (ppN/OFQ). NOP is a member of the seven transmembrane-spanning G-p