Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Niko Hensel"'
Autor:
Lucia Chehade, Marc-Olivier Deguise, Yves De Repentigny, Rebecca Yaworski, Ariane Beauvais, Sabrina Gagnon, Niko Hensel, Rashmi Kothary
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Spinal muscular atrophy (SMA) is a monogenic neuromuscular disease caused by low levels of the Survival Motor Neuron (SMN) protein. Motor neuron degeneration is the central hallmark of the disease. However, the SMN protein is ubiquitously expressed a
Externí odkaz:
https://doaj.org/article/7012f123c6254c638026160eccd82345
Autor:
Niko Hensel, Verena Raker, Benjamin Förthmann, Nora Tula Detering, Sabrina Kubinski, Anna Buch, Georgios Katzilieris-Petras, Julia Spanier, Viktoria Gudi, Sylvia Wagenknecht, Verena Kopfnagel, Thomas Andreas Werfel, Martin Stangel, Andreas Beineke, Ulrich Kalinke, Søren Riis Paludan, Beate Sodeik, Peter Claus
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-15 (2019)
Abstract Background Herpes simplex virus-1 (HSV-1) infections of the central nervous system (CNS) can result in HSV-1 encephalitis (HSE) which is characterized by severe brain damage and long-term disabilities. Different cell types including neurons
Externí odkaz:
https://doaj.org/article/6e9d92d914bf4354b8b0dd0af8a1ce9c
Publikováno v:
Journal of Pediatric Research, Vol 6, Iss 2, Pp 148-154 (2019)
Aim:Spinal muscular atrophy (SMA) is a devastating genetic disease in childhood andff is caused by the absence of functional survival motor neuron (SMN) protein, which leads to impairments of the cytoskeleton, especially in neurons. Dysregulation of
Externí odkaz:
https://doaj.org/article/74ac782f76b94adf9311ac571ccd4023
Autor:
Niko Hensel, Verena Raker, Benjamin Förthmann, Anna Buch, Beate Sodeik, Andreas Pich, Peter Claus
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Infections of the brain with herpes simplex virus type 1 (HSV-1) cause life-threatening Herpes simplex encephalitis (HSE) characterized by viral replication in neurons and neuro-inflammation including an infiltration of peripheral immune cells. HSV-1
Externí odkaz:
https://doaj.org/article/4ca3f12285284995a71803bd15aaab63
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Spinal Muscular Atrophy (SMA) is monogenic motoneuron disease caused by low levels of the Survival of Motoneuron protein (SMN). Recently, two different drugs were approved for the treatment of the disease. The antisense oligonucleotide Nusinersen/Spi
Externí odkaz:
https://doaj.org/article/5406940cce7d4e4f8d03cf20ca1b2fc5
Autor:
Niko Hensel, Svetlana Baskal, Lisa Marie Walter, Hella Brinkmann, Manuela Gernert, Peter Claus
Publikováno v:
Neurobiology of Disease, Vol 108, Iss , Pp 352-361 (2017)
Spinal Muscular Atrophy (SMA) is a motoneuron disease caused by low levels of functional survival of motoneuron protein (SMN). Molecular disease mechanisms downstream of functional SMN loss are still largely unknown. Previous studies suggested an inv
Externí odkaz:
https://doaj.org/article/5753b7c189d14319b5f806d2343fe651
Autor:
Hui Sun, Karelle Bénardais, Nancy Stanslowsky, Nadine Thau-Habermann, Niko Hensel, Dongya Huang, Peter Claus, Reinhard Dengler, Martin Stangel, Susanne Petri
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e72926 (2013)
Administration of mesenchymal stromal cells (MSC) improves functional outcome in the SOD1G93A mouse model of the degenerative motor neuron disorder amyotrophic lateral sclerosis (ALS) as well as in models of other neurological disorders. We have now
Externí odkaz:
https://doaj.org/article/35457bc4720b499aac82aaaa09510700
Autor:
Niko Hensel, Andreas Ratzka, Hella Brinkmann, Lars Klimaschewski, Claudia Grothe, Peter Claus
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31202 (2012)
The monogenetic disease Spinal Muscular Atrophy (SMA) is characterized by a progressive loss of motoneurons leading to muscle weakness and atrophy due to severe reduction of the Survival of Motoneuron (SMN) protein. Several models of SMA show deficit
Externí odkaz:
https://doaj.org/article/9cb7fde236e0447e83c381a4b12515ed
Autor:
Nora Tula Detering, Alberto Zambon, Niko Hensel, Rashmi Kothary, Kathryn Swoboda, Thomas H. Gillingwater, Giovanni Baranello, Simon Parson, Mariascristina Scoto, Melissa Bowerman, John Vissing, Brunhilde Wirth, Peter Claus, Janbernd Kirschner, Enrico Bertini, Stefania Corti, Lorenzo Maggi, Ludo van der Pol, Ewout Groen, Charlotte Sumner, Eduardo Tizzano, Susana Quijano Roy, Isabelle Desguerre, Alexander Van Nuijs, Mencia De Lemus, Rivka Smit, Mary Schroth, Ben Tichler, Ksenija Gorni, Deepa Chand
Publikováno v:
Neuromuscular Disorders. 32:697-705
Publikováno v:
Cellular and molecular life sciences : CMLS. 79(9)
Spinal muscular atrophy (SMA) is caused by low levels of the survival of motoneuron (SMN) Protein leading to preferential degeneration of lower motoneurons in the ventral horn of the spinal cord and brain stem. However, the SMN protein is ubiquitousl