Zobrazeno 1 - 10
of 358
pro vyhledávání: '"Niko, Beerenwinkel"'
Autor:
Rebekka Wegmann, Ximena Bonilla, Ruben Casanova, Stéphane Chevrier, Ricardo Coelho, Cinzia Esposito, Joanna Ficek-Pascual, Sandra Goetze, Gabriele Gut, Francis Jacob, Andrea Jacobs, Jack Kuipers, Ulrike Lischetti, Julien Mena, Emanuela S. Milani, Michael Prummer, Jacobo Sarabia Del Castillo, Franziska Singer, Sujana Sivapatham, Nora C. Toussaint, Oliver Vilinovszki, Mattheus H. E. Wildschut, Tharshika Thavayogarajah, Disha Malani, The TumorProfiler Consortium, Rudolf Aebersold, Marina Bacac, Niko Beerenwinkel, Christian Beisel, Bernd Bodenmiller, Viola Heinzelmann-Schwarz, Viktor H. Koelzer, Mitchell P. Levesque, Holger Moch, Lucas Pelkmans, Gunnar Rätsch, Markus Tolnay, Andreas Wicki, Bernd Wollscheid, Markus G. Manz, Berend Snijder, Alexandre P. A. Theocharides
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Deep single-cell multi-omic profiling offers a promising approach to understand and overcome drug resistance in relapsed or refractory (rr) acute myeloid leukemia (AML). Here, we combine single-cell ex vivo drug profiling (pharmacoscopy) wit
Externí odkaz:
https://doaj.org/article/d909919fc46044dd87b6ffb2a1e8a194
Autor:
Pelin Icer Baykal, Paweł Piotr Łabaj, Florian Markowetz, Lynn M. Schriml, Daniel J. Stekhoven, Serghei Mangul, Niko Beerenwinkel
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-15 (2024)
Abstract In biomedical research, validating a scientific discovery hinges on the reproducibility of its experimental results. However, in genomics, the definition and implementation of reproducibility remain imprecise. We argue that genomic reproduci
Externí odkaz:
https://doaj.org/article/ae2a6c1b413c43adbd2c70e8da75d063
Autor:
Stefanie Hossmann, Antoine Jaquet, Matthias Egger, Richard Lessells, Jeremy Ross, Mamatha Sauermann, Tom Loosli, Selma Riedo, Niko Beerenwinkel, Albert Minga, Jennifer Giandhari, Roger D Kouyos
Publikováno v:
BMJ Open, Vol 14, Iss 8 (2024)
Introduction HIV drug resistance poses a challenge to the United Nation’s goal of ending the HIV/AIDS epidemic. The integrase strand transfer inhibitor (InSTI) dolutegravir, which has a higher resistance barrier, was endorsed by the WHO in 2019 for
Externí odkaz:
https://doaj.org/article/cdb698d44ddf40a39cf421b625d97203
Autor:
Fanny Wegner, Blanca Cabrera-Gil, Araud Tanguy, Christiane Beckmann, Niko Beerenwinkel, Claire Bertelli, Matteo Carrara, Lorenzo Cerutti, Chaoran Chen, Samuel Cordey, Alexis Dumoulin, Louis du Plessis, Marc Friedli, Yannick Gerth, Gilbert Greub, Adrian Härri, Hans Hirsch, Cedric Howald, Michael Huber, Alexander Imhof, Laurent Kaiser, Verena Kufner, Stephen L. Leib, Karoline Leuzinger, Etleva Lleshi, Gladys Martinetti, Mirjam Mäusezahl, Milo Moraz, Richard Neher, Oliver Nolte, Alban Ramette, Maurice Redondo, Lorenz Risch, Lionel Rohner, Tim Roloff, Pascal Schläepfer, Katrin Schneider, Franziska Singer, Valeria Spina, Tanja Stadler, Erik Studer, Ivan Topolsky, Alexandra Trkola, Daniel Walther, Nadia Wohlwend, Cinzia Zehnder, Aitana Neves, Adrian Egli
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 5 (2024)
ABSTRACTDuring the SARS-CoV-2 pandemic, many countries directed substantial resources toward genomic surveillance to detect and track viral variants. There is a debate over how much sequencing effort is necessary in national surveillance programs for
Externí odkaz:
https://doaj.org/article/c4ccaa18016f452ba4419207aed44b4b
Autor:
Arthur Dondi, Ulrike Lischetti, Francis Jacob, Franziska Singer, Nico Borgsmüller, Ricardo Coelho, Tumor Profiler Consortium, Viola Heinzelmann-Schwarz, Christian Beisel, Niko Beerenwinkel
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Understanding the complex background of cancer requires genotype-phenotype information in single-cell resolution. Here, we perform long-read single-cell RNA sequencing (scRNA-seq) on clinical samples from three ovarian cancer patients presen
Externí odkaz:
https://doaj.org/article/a6ca4dd2f21440459a66c8a701729688
Autor:
Mathias Cardner, Francesco Marass, Erika Gedvilaite, Julie L. Yang, Dana W. Y. Tsui, Niko Beerenwinkel
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-9 (2023)
Abstract Background Liquid biopsy is a minimally-invasive method of sampling bodily fluids, capable of revealing evidence of cancer. The distribution of cell-free DNA (cfDNA) fragment lengths has been shown to differ between healthy subjects and canc
Externí odkaz:
https://doaj.org/article/bbde033bd9784290b10587b1b299e0ba
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Reconstructing the history of somatic DNA alterations can help understand the evolution of a tumor and predict its resistance to treatment. Single-cell DNA sequencing (scDNAseq) can be used to investigate clonal heterogeneity and to inform p
Externí odkaz:
https://doaj.org/article/5f81aed31c784eff80c00c66b4192dda
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Cancer progression is an evolutionary process shaped by both deterministic and stochastic forces. Multi-region and single-cell sequencing of tumors enable high-resolution reconstruction of the mutational history of each tumor and highlight t
Externí odkaz:
https://doaj.org/article/4690b2c5113f4450b93657b7b3827168
Autor:
Viktor Zaika, Meher K. Prakash, Chih-Yuan Cheng, Michael Schlander, Brian M. Lang, Niko Beerenwinkel, Amnon Sonnenberg, Niklas Krupka, Benjamin Misselwitz, Jan Poleszczuk
Publikováno v:
PLoS ONE, Vol 19, Iss 5 (2024)
Externí odkaz:
https://doaj.org/article/f24e725d45b34fb6b067f4811b3444f0
Autor:
Mayuri Inchanalkar, Sumana Srivatsa, Srikant Ambatipudi, Priyanka G. Bhosale, Asawari Patil, Alejandro A. Schäffer, Niko Beerenwinkel, Manoj B. Mahimkar
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-16 (2023)
Abstract Background Gingivobuccal complex oral squamous cell carcinoma (GBC-OSCC) is an aggressive malignancy with high mortality often preceded by premalignant lesions, including leukoplakia. Previous studies have reported genomic drivers in OSCC, b
Externí odkaz:
https://doaj.org/article/68e3d9c0391a4ad49e33391560a83b9e