3D genomic mapping reveals multifocality of human pancreatic precancers.

Autor: Braxton AM; Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Comparative Medicine, Medical University of South Carolina, Charleston, SC, USA., Kiemen AL; Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA.; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Grahn MP; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA., Forjaz A; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA., Parksong J; Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Mahesh Babu J; Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Lai J; Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD, USA., Zheng L; Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD, USA.; McKusick-Nathans Institute for Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA., Niknafs N; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Jiang L; State Key Laboratory of Molecular Oncology, National Cancer Center, National Clinical Research Center for Cancer and Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Cheng H; State Key Laboratory of Molecular Oncology, National Cancer Center, National Clinical Research Center for Cancer and Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Song Q; State Key Laboratory of Molecular Oncology, National Cancer Center, National Clinical Research Center for Cancer and Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Reichel R; Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Graham S; Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Damanakis AI; Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Fischer CG; Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Mou S; Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Metz C; Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Granger J; Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Liu XD; Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Pathology, Molecular Pathology Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China., Bachmann N; Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Zhu Y; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA., Liu Y; Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD, USA., Almagro-Pérez C; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA., Jiang AC; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA., Yoo J; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA., Kim B; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA., Du S; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA., Foster E; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA., Hsu JY; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA., Rivera PA; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA., Chu LC; Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Liu F; Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Fishman EK; Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Yuille A; Department of Computer Science, Johns Hopkins University, Baltimore, MD, USA., Roberts NJ; Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Thompson ED; Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Scharpf RB; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Cornish TC; Department of Pathology, University of Colorado School of Medicine, Aurora, CO, USA., Jiao Y; State Key Laboratory of Molecular Oncology, National Cancer Center, National Clinical Research Center for Cancer and Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. jiaoyuchen@gmail.com.; Institute of Cancer Research, Henan Academy of Innovations in Medical Science, Zhengzhou, China. jiaoyuchen@gmail.com., Karchin R; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; McKusick-Nathans Institute for Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA., Hruban RH; Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Wu PH; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA., Wirtz D; Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA. wirtz@jhu.edu.; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA. wirtz@jhu.edu.; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA. wirtz@jhu.edu., Wood LD; Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA. ldwood@jhmi.edu.; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA. ldwood@jhmi.edu.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA. ldwood@jhmi.edu.

Publikováno v: Nature [Nature] 2024 May; Vol. 629 (8012), pp. 679-687. Date of Electronic Publication: 2024 May 01.

Early detection of ovarian cancer using cell-free DNA fragmentomes and protein biomarkers.

Autor: Medina JE; Johns Hopkins Medicine, Baltimore, MD, United States., Annapragada AV; Johns Hopkins Medicine, Baltimore, MD, United States., Lof P; Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Netherlands., Short S; Johns Hopkins Medicine, Baltimore, MD, United States., Bartolomucci AL; Johns Hopkins Medicine, Baltimore, MD, United States., Mathios D; Johns Hopkins Medicine, Baltimore, MD, United States., Koul S; Johns Hopkins Medicine, Baltimore, MD, United States., Niknafs N; Johns Hopkins University, Baltimore, MD, United States., Noe M; Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Baltimore, MD, United States., Foda ZH; Johns Hopkins Medicine, Baltimore, United States., Bruhm DC; Johns Hopkins Medicine, Baltimore, MD, United States., Hruban C; Johns Hopkins Medicine, Baltimore, MD, United States., Vulpescu NA; Johns Hopkins University Hospital, Baltimore, United States., Jung E; University of Pennsylvania, Philadelphia, Pennsylvania, United States., Dua R; Johns Hopkins Medicine, Baltimore, MD, United States., Canzoniero JV; Johns Hopkins Medicine, Baltimore, Maryland, United States., Cristiano S; Johns Hopkins Medicine, Baltimore, MD, United States., Adleff V; Johns Hopkins Medicine, Baltimore, MD, United States., Symecko H; University of Pennsylvania, Philadelphia, PA, United States., van den Broek D; Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, Netherlands., Sokoll LJ; Johns Hopkins Medicine, Baltimore, Maryland, United States., Baylin SB; Johns Hopkins Medicine, Baltimore, MD, United States., Press MF; University of Southern California, Los Angeles, CA, United States., Slamon DJ; Geffen School of Medicine at UCLA, Los Angeles, CA, United States., Konecny GE; University of California, Los Angeles, Los Angeles, CA, United States., Therkildsen C; Copenhagen University Hospital, Amager and Hvidovre, Copenhagen, Hvidovre, Denmark., Carvalho B; Netherlands Cancer Institute, Amsterdam, Netherlands., Meijer GA; Netherlands Cancer Institute, Amsterdam, Netherlands., Andersen CL; Aarhus University Hospital, Aarhus N, Denmark., Domchek SM; University of Pennsylvania, Philadelphia, PA, United States., Drapkin R; University of Pennsylvania School of Medicine, Philadelphia, PA, United States., Scharpf RB; Johns Hopkins Medicine, Baltimore, United States., Phallen J; Johns Hopkins Medicine, Baltimore, MD, United States., Lok CAR; Netherlands Cancer Institute, Amsterdam, Netherlands., Velculescu VE; Johns Hopkins Medicine, Baltimore, MD, United States.

Publikováno v: Cancer discovery [Cancer Discov] 2024 Sep 30. Date of Electronic Publication: 2024 Sep 30.

Tracing the genetic fingerprints of tumour evolution: The pursuit of identifying mutations with differential weights within the overall tumour mutation burden and their role in therapeutic responses with immune checkpoint blockade.

Autor: Niknafs N; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland., Conroy M; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland., Anagnostou V; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Publikováno v: Clinical and translational medicine [Clin Transl Med] 2023 Jun; Vol. 13 (6), pp. e1287.

Elucidating the Heterogeneity of Immunotherapy Response and Immune-Related Toxicities by Longitudinal ctDNA and Immune Cell Compartment Tracking in Lung Cancer.

Autor: Murray JC; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland.; The Lung Cancer Precision Medicine Center of Excellence, Johns Hopkins University School of Medicine, Baltimore, Maryland., Sivapalan L; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland., Hummelink K; Antoni van Leeuwenhoek Nederlands Kanker Instituut, Amsterdam, the Netherlands., Balan A; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland., White JR; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland., Niknafs N; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland., Rhymee L; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland., Pereira G; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland., Rao N; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland., Weksler B; Allegheny Health Network Cancer Institute, Allegheny Health Network, Pittsburgh, Pennsylvania., Bahary N; Allegheny Health Network Cancer Institute, Allegheny Health Network, Pittsburgh, Pennsylvania., Phallen J; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland., Leal A; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland., Bartlett DL; Allegheny Health Network Cancer Institute, Allegheny Health Network, Pittsburgh, Pennsylvania., Marrone KA; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; The Lung Cancer Precision Medicine Center of Excellence, Johns Hopkins University School of Medicine, Baltimore, Maryland., Naidoo J; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Beaumont RCSI Cancer Centre, Dublin, Ireland., Goel A; California Institute of Technology, 1200 E California Blvd, Pasadena, California., Levy B; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland., Rosner S; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland., Hann CL; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland., Scott SC; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland., Feliciano J; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland., Lam VK; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland., Ettinger DS; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland., Li QK; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Department of Pathology, Johns Hopkins University, Baltimore, Maryland., Illei PB; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Department of Pathology, Johns Hopkins University, Baltimore, Maryland., Monkhorst K; Antoni van Leeuwenhoek Nederlands Kanker Instituut, Amsterdam, the Netherlands., Scharpf RB; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland., Brahmer JR; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland.; The Lung Cancer Precision Medicine Center of Excellence, Johns Hopkins University School of Medicine, Baltimore, Maryland., Velculescu VE; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland., Zaidi AH; Allegheny Health Network Cancer Institute, Allegheny Health Network, Pittsburgh, Pennsylvania., Forde PM; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland., Anagnostou V; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland.; The Lung Cancer Precision Medicine Center of Excellence, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2024 Jan 17; Vol. 30 (2), pp. 389-403.

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