Development of non-alcoholic steatohepatitis is associated with gut microbiota but not with oxysterol enzymes CH25H, EBI2, or CYP7B1 in mice

Autor: Jacqueline Wyss, Tina Raselli, Annika Wyss, Anja Telzerow, Gerhard Rogler, Niklas Krupka, Bahtiyar Yilmaz, Thomas S. B. Schmidt, Benjamin Misselwitz

Publikováno v: BMC Microbiology, Vol 24, Iss 1, Pp 1-15 (2024)

Abstract Liver steatosis is the most frequent liver disorder and its advanced stage, non-alcoholic steatohepatitis (NASH), will soon become the main reason for liver fibrosis and cirrhosis. The “multiple hits hypothesis” suggests that progression

Externí odkaz: https://doaj.org/article/64a0228787cf4ef0a13a6ec4944cab18

Because I’m happy – positive affect and its predictive value for future disease activity in patients with inflammatory bowel diseases: a retrospective cohort study

Autor: Brian M. Lang, Martina Ledergerber, Sebastian Bruno Ulrich Jordi, Niklas Krupka, Luc Biedermann, Philipp Schreiner, Pascal Juillerat, Jacqueline Wyss, Stephan R. Vavricka, Jonas Zeitz, Roland von Känel, Gerhard Rogler, Niko Beerenwinkel, Benjamin Misselwitz

Publikováno v: Therapeutic Advances in Gastroenterology, Vol 16 (2023)

Background: While the detrimental impact of negative emotions on the clinical course of inflammatory bowel disease (IBD) and quality of life has been extensively investigated, evidence for a potential impact of positive emotions is scarce. Objectives

Externí odkaz: https://doaj.org/article/821caaed25dc40018285a2c701013436

Effectiveness of golimumab in patients with ulcerative colitis: results of a real-life study in Switzerland

Autor: Kathrin Perrig, Niklas Krupka, Sebastian Bruno Ulrich Jordi, Jean-Benoît Rossel, Luc Biedermann, Thomas Greuter, Philipp Schreiner, Stephan R. Vavricka, Pascal Juillerat, Emanuel Burri, Dorothee Zimmermann, Michel H. Maillard, Michael Christian Sulz, Stephan Brand, Gerhard Rogler, Benjamin Misselwitz

Publikováno v: Therapeutic Advances in Gastroenterology, Vol 15 (2022)

Background: Tumor necrosis factor (TNF) inhibitors have improved treatment of ulcerative colitis (UC), but loss of response remains a frequent problem. The anti-TNF agent, golimumab, was approved in Switzerland for the treatment of UC in 2014. This s

Externí odkaz: https://doaj.org/article/3dc3da4e952b4b73bcb7635cd040ba58

Effects of anti-TNF therapy and immunomodulators on anxiety and depressive symptoms in patients with inflammatory bowel disease: a 5-year analysis

Autor: Alexander R. Siebenhüner, Jean-Benoît Rossel, Philipp Schreiner, Matthias Butter, Thomas Greuter, Niklas Krupka, Sebastian B. U. Jordi, Luc Biedermann, Gerhard Rogler, Benjamin Misselwitz, Roland von Känel

Publikováno v: Therapeutic Advances in Gastroenterology, Vol 14 (2021)

Background and aims: Anxiety and depression are prevalent in patients with inflammatory bowel diseases (IBD), especially during IBD flares. IBD therapies can profoundly affect the mood of patients with IBD. We aimed to determine the long-term impact

Externí odkaz: https://doaj.org/article/43745c5791f945d5ac13a25da3873fd3

The personality traits activity, self-reproach, and negative affect jointly predict clinical recurrence, depressive symptoms, and low quality of life in inflammatory bowel disease patients

Autor: Sebastian Bruno Ulrich, Jordi, Brian Matthew, Lang, Jacqueline, Wyss, Bianca, Auschra, Bahtiyar, Yilmaz, Niklas, Krupka, Thomas, Greuter, Philipp, Schreiner, Luc, Biedermann, Martin, Preisig, Roland, von Känel, Gerhard, Rogler, Stefan, Begré, Benjamin, Misselwitz, Dorothee, Zimmermann

Publikováno v: Journal of gastroenterology, vol. 57, no. 11, pp. 848-866
Jordi, Sebastian Bruno Ulrich; Lang, Brian Matthew; Wyss, Jacqueline; Auschra, Bianca; Yilmaz, Bahtiyar; Krupka, Niklas; Greuter, Thomas; Schreiner, Philipp; Biedermann, Luc; Preisig, Martin; von Känel, Roland; Rogler, Gerhard; Begré, Stefan; Misselwitz, Benjamin (2022). The personality traits activity, self-reproach, and negative affect jointly predict clinical recurrence, depressive symptoms, and low quality of life in inflammatory bowel disease patients. Journal of gastroenterology, 57(11), pp. 848-866. Springer 10.1007/s00535-022-01902-7

Background The bidirectional “gut-brain axis” has been implicated in the pathogenesis of inflammatory bowel diseases (IBD). While the influence of stress and depressive symptoms on IBD is well-characterized, the role of personality remains insuff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2cf9ed1b3a9a87e44fd69d0cf62fb3f
https://serval.unil.ch/notice/serval:BIB_F1C754D68334