Membrane transporters control cerebrospinal fluid formation independently of conventional osmosis to modulate intracranial pressure

Autor: Eva K. Oernbo, Annette B. Steffensen, Pooya Razzaghi Khamesi, Trine L. Toft-Bertelsen, Dagne Barbuskaite, Frederik Vilhardt, Niklas J. Gerkau, Katerina Tritsaris, Anja H. Simonsen, Sara D. Lolansen, Søren N. Andreassen, Steen G. Hasselbalch, Thomas Zeuthen, Christine R. Rose, Vartan Kurtcuoglu, Nanna MacAulay

Publikováno v: Fluids and Barriers of the CNS, Vol 19, Iss 1, Pp 1-25 (2022)

Abstract Background Disturbances in the brain fluid balance can lead to life-threatening elevation in the intracranial pressure (ICP), which represents a vast clinical challenge. Nevertheless, the details underlying the molecular mechanisms governing

Externí odkaz: https://doaj.org/article/5f05e5d9134e47b3a3b4351767140f5a

Changes in Astroglial K+ upon Brief Periods of Energy Deprivation in the Mouse Neocortex

Autor: Sara Eitelmann, Jonathan Stephan, Katharina Everaerts, Simone Durry, Nils Pape, Niklas J. Gerkau, Christine R. Rose

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 9, p 4836 (2022)

Malfunction of astrocytic K+ regulation contributes to the breakdown of extracellular K+ homeostasis during ischemia and spreading depolarization events. Studying astroglial K+ changes is, however, hampered by a lack of suitable techniques. Here, we

Externí odkaz: https://doaj.org/article/a0916738768c4fa6a663d9865970d1ea

Rapid Fluorescence Lifetime Imaging Reveals That TRPV4 Channels Promote Dysregulation of Neuronal Na+ in Ischemia

Autor: Jan Meyer, Niklas J. Gerkau, Karl W. Kafitz, Matthias Patting, Fabian Jolmes, Christian Henneberger, Christine R. Rose

Publikováno v: The journal of neuroscience 42(4), 552-566 (2021). doi:10.1523/JNEUROSCI.0819-21.2021
J Neurosci

Fluorescence imaging is an indispensable method for analysis of diverse cellular and molecular processes, enabling, for example, detection of ions, second messengers, or metabolites. Intensity-based approaches, however, are prone to artifacts introdu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8f3adb9969e8f875b239e3d6231c96f
https://pub.dzne.de/record/163301

Heterogeneity of Activity-Induced Sodium Transients between Astrocytes of the Mouse Hippocampus and Neocortex: Mechanisms and Consequences

Autor: Christine R. Rose, Franziska Oschmann, Daniel Ziemens, Niklas J. Gerkau

Publikováno v: The Journal of Neuroscience. 39:2620-2634

Activity-related sodium transients induced by glutamate uptake represent a special form of astrocyte excitability. Astrocytes of the neocortex, as opposed to the hippocampus proper, also express ionotropic glutamate receptors, which might provide add

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02fb7ec6bb71869055b5f367561a19a5
https://doi.org/10.1523/jneurosci.2029-18.2019

Cotransporter-mediated water transport underlying cerebrospinal fluid formation

Autor: Niklas J. Gerkau, Katerina Tritsaris, Nanna MacAulay, Eva Kjer Oernbo, Anca Stoica, Christine R. Rose, Dagne Barbuskaite, Annette Buur Steffensen

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Steffensen, A B, Oernbo, E K, Stoica, A, Gerkau, N J, Barbuskaite, D, Tritsaris, K, Rose, C R & MacAulay, N 2018, ' Cotransporter-mediated water transport underlying cerebrospinal fluid formation ', Nature Communications, vol. 9, no. 1, 2167 . https://doi.org/10.1038/s41467-018-04677-9
Nature Communications

Cerebrospinal fluid (CSF) production occurs at a rate of 500 ml per day in the adult human. Conventional osmotic forces do not suffice to support such production rate and the molecular mechanisms underlying this fluid production remain elusive. Using

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0c2ef40837deacbe218e2f37c32de8d
https://doaj.org/article/543501b1f622450685d52b070f2b2f83