Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Niklas J, Koehl"'
Autor:
Laura J. Henze, Niklas J. Koehl, Joseph P. O'Shea, René Holm, Maria Vertzoni, Brendan T. Griffin
Publikováno v:
International Journal of Pharmaceutics: X, Vol 1, Iss , Pp - (2019)
A preclinical porcine model that reliably predicts human food effect of fenofibrate was developed. Fenofibrate was administered to pigs as model compound with a positive food effect. Two different types of fed conditions were explored: a FDA style br
Externí odkaz:
https://doaj.org/article/b0e53c7d835c4cd195b7ef88274c3811
Publikováno v:
Pharmaceutics, Vol 12, Iss 6, p 564 (2020)
Increasing numbers of beyond Rule-of-Five drugs are emerging from discovery pipelines, generating a need for bio-enabling formulation approaches, such as lipid-based formulations (LBF), to ensure maximal in vivo exposure. However, many drug candidate
Externí odkaz:
https://doaj.org/article/e8396e284ac84c49a16691b9fa38b952
Autor:
Hans Coppenolle, Ingrid Djouka Tenekam, Sanket M. Shah, Nicolas Sauwen, Niklas J. Koehl, René Holm, Sien Vingerhoets, Tatsiana Khamiakova
Publikováno v:
Koehl, N J, Shah, S, Tenekam, I D, Khamiakova, T, Sauwen, N, Vingerhoets, S, Coppenolle, H & Holm, R 2021, ' Lipid Based Formulations in Hard Gelatin and HPMC Capsules : a Physical Compatibility Study ', Pharmaceutical Research, vol. 38, no. 8, pp. 1439-1454 . https://doi.org/10.1007/s11095-021-03088-8
Purpose: To investigate the compatibility between hard gelatin and HPMC capsules with a range of different isotropic lipid based formulations containing multiple excipients. Methods: The miscibility was investigated for 350 systems applying five diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::300bcef8f1e425589fb7789904303b68
https://doi.org/10.1007/s11095-021-03088-8
https://doi.org/10.1007/s11095-021-03088-8
Autor:
Andreas Marx, Niklas J. Koehl, René Holm, Brendan T. Griffin, John J. Keating, Thomas De Vijlder, Martin Kuentz, Laura J. Henze
Publikováno v:
Koehl, N J, Henze, L J, Holm, R, Kuentz, M, Keating, J J, De Vijlder, T, Marx, A & Griffin, B T 2022, ' Lipophilic Salts and Lipid-Based Formulations for Bridging the Food Effect Gap of Venetoclax ', Journal of Pharmaceutical Sciences, vol. 111, no. 1, pp. 164-174 . https://doi.org/10.1016/j.xphs.2021.09.008
Lipid based formulations (LBF) have shown to overcome food dependent bioavailability for some poorly water-soluble drugs. However, the utility of LBFs can be limited by low dose loading due to a low drug solubility in LBF vehicles. This study investi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::891f5094421f520bc605cb9eabbe0467
https://portal.findresearcher.sdu.dk/da/publications/8739040f-91e7-49b7-ae10-38595606aa5f
https://portal.findresearcher.sdu.dk/da/publications/8739040f-91e7-49b7-ae10-38595606aa5f
Autor:
Niklas J, Koehl, Sanket, Shah, Ingrid Djouka, Tenekam, Tatsiana, Khamiakova, Nicolas, Sauwen, Sien, Vingerhoets, Hans, Coppenolle, René, Holm
Publikováno v:
Pharmaceutical research. 38(8)
To investigate the compatibility between hard gelatin and HPMC capsules with a range of different isotropic lipid based formulations containing multiple excipients.The miscibility was investigated for 350 systems applying five different oils (Labrafa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4e685d9eb2be2d60fe954451b0747976
https://pubmed.ncbi.nlm.nih.gov/34378150
https://pubmed.ncbi.nlm.nih.gov/34378150
Autor:
Niklas J. Koehl, René Holm, Laura J. Henze, Maria Vertzoni, Joseph P. O'Shea, Brendan T. Griffin
The pig has been increasingly used as a reliable preclinical model for assessing and predicting the in vivo bioavailability of different formulation strategies. Nevertheless, differences in the composition between porcine and human intestinal fluids,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::226fa1ba7d8ec9c4774bb9f66c4003db
https://hdl.handle.net/10468/11444
https://hdl.handle.net/10468/11444
Autor:
Martin Kuentz, Niklas J. Koehl, Daniel J. Price, René Holm, Laura J. Henze, Harriet Bennett-Lenane, Waleed Faisal, Brendan T. Griffin
Publikováno v:
Koehl, N J, Henze, L J, Bennett-Lenane, H, Faisal, W, Price, D J, Holm, R, Kuentz, M & Griffin, B T 2021, ' In Silico, in Vitro, and in Vivo Evaluation of Precipitation Inhibitors in Supersaturated Lipid-Based Formulations of Venetoclax ', Molecular Pharmaceutics, vol. 18, no. 6, pp. 2174-2188 . https://doi.org/10.1021/acs.molpharmaceut.0c00645
Molecular Pharmaceutics
Molecular Pharmaceutics
The concept of using precipitation inhibitors (PIs) to sustain supersaturation is well established for amorphous formulations but less in the case of lipid-based formulations (LBF). This study applied a systematic in silico-in vitro-in vivo approach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2776c425b60b01e7e53c4192e741d5b
https://findresearcher.sdu.dk:8443/ws/files/183357915/acs.molpharmaceut.0c00645.pdf
https://findresearcher.sdu.dk:8443/ws/files/183357915/acs.molpharmaceut.0c00645.pdf
Autor:
Laura J. Henze, Joseph P. O'Shea, Jacob Rune Jørgensen, Niklas J. Koehl, Harriet Bennett-Lenane, Anette Müllertz, Brendan T. Griffin
Publikováno v:
Bennett-Lenane, H, Jørgensen, J R, Koehl, N J, Henze, L J, O'Shea, J P, Müllertz, A & Griffin, B T 2021, ' Exploring Porcine Gastric and Intestinal Fluids using Microscopic and Solubility Estimates : Impact of Placebo Self-Emulsifying Drug Delivery System Administration to Inform Bio-Predictive in vitro Tools ', European Journal of Pharmaceutical Sciences, vol. 161, 105778 . https://doi.org/10.1016/j.ejps.2021.105778
Validation and characterisation of in vitro and pre-clinical animal models to support bio-enabling formulation development is of paramount importance. In this work, post-mortem gastric and small intestinal fluids were collected in the fasted, fed sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4fb52694411d08daffa803bad79c3bc
https://curis.ku.dk/ws/files/263034089/1_s2.0_S0928098721000804_main.pdf
https://curis.ku.dk/ws/files/263034089/1_s2.0_S0928098721000804_main.pdf
Autor:
Laura J. Henze, René Holm, Harriet Bennett-Lenane, Brendan T. Griffin, Werner Weitschies, Felix Schneider, Mirko Koziolek, Niklas J. Koehl, Michael Grimm
Publikováno v:
European Journal of Pharmaceutical Sciences
Within preclinical research, the pig has become an important model in regulatory toxicology and pharmacokinetics, to assess oral dosage forms and to compare different formulation strategies. In addition, there are emerging application of the pig mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6482651290bdf7248d4f9ab842919c46
https://hdl.handle.net/10468/11443
https://hdl.handle.net/10468/11443
Autor:
Patrick J, O'Dwyer, Karl J, Box, Niklas J, Koehl, Harriet, Bennett-Lenane, Christos, Reppas, Rene, Holm, Martin, Kuentz, Brendan T, Griffin
Publikováno v:
Molecular pharmaceutics. 17(9)
The absence of an intestinal absorption sink is a significant weakness of standard
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8453dee903d030d02f453f36e06421fd
https://pubmed.ncbi.nlm.nih.gov/32787274
https://pubmed.ncbi.nlm.nih.gov/32787274