Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Niklas Ivarsson"'
Autor:
Charlotte Gineste, Sonia Youhanna, Sabine U. Vorrink, Sara Henriksson, Andrés Hernández, Arthur J. Cheng, Thomas Chaillou, Andreas Buttgereit, Dominik Schneidereit, Oliver Friedrich, Kjell Hultenby, Joseph D. Bruton, Niklas Ivarsson, Linda Sandblad, Volker M. Lauschke, Håkan Westerblad
Publikováno v:
iScience, Vol 25, Iss 12, Pp 105654- (2022)
Summary: Cells rapidly lose their physiological phenotype upon disruption of their extracellular matrix (ECM)-intracellular cytoskeleton interactions. By comparing adult mouse skeletal muscle fibers, isolated either by mechanical dissection or by col
Externí odkaz:
https://doaj.org/article/28a20786507944e29cd08fe6371fe36e
Autor:
Sabine Lotteau, PhD, Niklas Ivarsson, PhD, Zhaokang Yang, PhD, Damien Restagno, PhD, John Colyer, PhD, Philip Hopkins, MD, Andrew Weightman, PhD, Koichi Himori, MSc, Takashi Yamada, PhD, Joseph Bruton, PhD, Derek Steele, PhD, Håkan Westerblad, MD, PhD, Sarah Calaghan, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 4, Iss 4, Pp 509-523 (2019)
Summary: This study aimed to identify a mechanism for statin-induced myopathy that explains its prevalence and selectivity for skeletal muscle, and to understand its interaction with moderate exercise. Statin-associated adverse muscle symptoms reduce
Externí odkaz:
https://doaj.org/article/78f53b25bad64710b444c80cfadf25d9
Autor:
Niklas Ivarsson, Håkan Westerblad
Publikováno v:
PLoS Genetics, Vol 11, Iss 1, p e1004908 (2015)
Externí odkaz:
https://doaj.org/article/a6108c956baa4e58b79bb0a00ffa9327
Publikováno v:
International Journal for Numerical Methods in Engineering. 122:4354-4377
An elastoplastic topology optimization framework for limiting plastic work generation while maximizing stiffness is presented. The kinematics and constitutive model are based on finite strain linear isotropic hardening plasticity, and the balance law
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dcdb32fd9289b820e56163840c6a58f8
https://doi.org/10.1002/nme.6706
https://doi.org/10.1002/nme.6706
Publikováno v:
Structural and Multidisciplinary Optimization. 61:2501-2521
This paper presents a topology optimization framework for designing periodic viscoplastic microstructures under finite deformation. To demonstrate the framework, microstructures with tailored macroscopic mechanical properties, e.g., maximum viscoplas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da0e7e21c12e4c908d94014bd77b8b76
https://doi.org/10.1007/s00158-020-02555-x
https://doi.org/10.1007/s00158-020-02555-x
Publikováno v:
Structural and Multidisciplinary Optimization. 62:1299-1311
Design variables in density-based topology optimization are typically regularized using filtering techniques. In many cases, such as stress optimization, where details at the boundaries are crucially important, the filtering in the vicinity of the de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2be55f86c8516320bec732aba0242724
https://doi.org/10.1007/s00158-020-02556-w
https://doi.org/10.1007/s00158-020-02556-w
Autor:
Ilary Allodi, Arthur J. Cheng, Maja Schlittler, Eva Hedlund, Sebastian Thams, Johanna T. Lanner, Niklas Ivarsson, Daniel C. Andersson, Thomas Chaillou
Publikováno v:
The Journal of Physiology. 597:3133-3146
Key points How defects in muscle contractile function contribute to weakness in amyotrophic lateral sclerosis (ALS) were systematically investigated. Weakness in whole muscles from late stage SOD1G93A mice was explained by muscle atrophy as seen by r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a08aecc0d38b77bd8412ba6bae48d1f8
https://doi.org/10.1113/jp277456
https://doi.org/10.1113/jp277456
Autor:
Johanna T. Lanner, Niklas Ivarsson, C. Mikael Mattsson, Håkan Westerblad, Joseph D. Bruton, Arthur J. Cheng, Björn Ekblom
Publikováno v:
The Journal of General Physiology
Skeletal muscle oxidative capacity and fatigue resistance can be improved with endurance training, but the mechanism is not fully understood. Ivarsson et al. find that the signaling pathway that increases fatigue resistance in muscle is triggered by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21f5166e0ffb823af660955c2669e05c
http://europepmc.org/articles/PMC6445590
http://europepmc.org/articles/PMC6445590
Autor:
Anna Reymer, Anders Karlsson, Anaswara Ashok, Emma Johnsson, Jessica Hägglund, Joseph D. Bruton, Roger Karlsson, Kent Jardemark, Sreesha P. Srinivasa, Monica M. Marcus, Niklas Ivarsson, Max Davidson, Alexandra Cavallin, Daniela Papadia, Maria-Nefeli Christakopoulou, Carolina Trkulja, Gavin D. M. Jeffries, Oscar Jungholm, Owe Orwar, Peder Svensson, Gabriella Willman
Publikováno v:
Science Advances
This newly developed biological probes/proteomics method yields functional antibodies targeting previously undruggable targets.
Several important drug targets, e.g., ion channels and G protein–coupled receptors, are extremely difficult to appr
Several important drug targets, e.g., ion channels and G protein–coupled receptors, are extremely difficult to appr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47eee435e07f64b09fb51d7390a5a75f
https://doi.org/10.1126/sciadv.abe6397
https://doi.org/10.1126/sciadv.abe6397
Autor:
Thomas Chaillou, Kjell Hultenby, Sonia Youhanna, Sabine U. Vorrink, Arthur J. Cheng, Oliver Friedrich, Andrés Hernández, Joseph D. Bruton, Volker M. Lauschke, Linda Sandblad, Sara Henriksson, Håkan Westerblad, Dominik Schneidereit, Andreas Buttgereit, Charlotte Gineste, Niklas Ivarsson
SummaryCells rapidly lose their physiological phenotype upon disruption of their extracellular matrix (ECM)-intracellular cytoskeleton interactions. Here, we investigated acute effects of ECM disruption on cellular and mitochondrial morphology, trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a5dc2ad18292d945e196e4e6ab78f4b
https://doi.org/10.1101/2021.03.29.437546
https://doi.org/10.1101/2021.03.29.437546
