In Vivo siRNA Delivery to Immunosuppressive Liver Macrophages by α-Mannosyl-Functionalized Cationic Nanohydrogel Particles

Autor: Leonard Kaps, Nadine Leber, Adrian Klefenz, Niklas Choteschovsky, Rudolf Zentel, Lutz Nuhn, Detlef Schuppan

Publikováno v: Cells, Vol 9, Iss 8, p 1905 (2020)

Macrophages are the front soldiers of the innate immune system and are vital for immune defense, tumor surveillance, and tissue homeostasis. In chronic diseases, including cancer and liver fibrosis, macrophages can be forced into an immunosuppressive

Externí odkaz: https://doaj.org/article/4d8eb39bb696418297d7b56b104ed0f8

Squaric Ester-Based, pH-Degradable Nanogels: Modular Nanocarriers for Safe, Systemic Administration of Toll-like Receptor 7/8 Agonistic Immune Modulators

Autor: Jana De Vrieze, Carolina Medina-Montano, Bruno G. De Geest, Niklas Choteschovsky, Niek N. Sanders, Stefan Lienenklaus, Bart N. Lambrecht, Matthias Bros, Kim Deswarte, Anne Huppertsberg, Christian Czysch, Kaloian Koynov, Lutz Nuhn, Judith Stickdorn, Detlef Schuppan, Francis Combes, Adrian Klefenz, Sascha Schmitt, Leonard Kaps, Sabah Kasmi, Chaojian Chen, Sunil A. David, Zifu Zhong, Pia Winterwerber

Publikováno v: Journal of the American Chemical Society
Journal of the American Chemical Society, 143(26), 9872-9883. American Chemical Society
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Small-molecular Toll-like receptor 7/8 (TLR7/8) agonists hold promise as immune modulators for a variety of immune therapeutic purposes including cancer therapy or vaccination. However, due to their rapid systemic distribution causing difficult-to-co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdd18e50dbec4b32f50d7dc98705510e
https://hdl.handle.net/21.11116/0000-0008-F185-121.11116/0000-0008-C1FD-1

Generation of syngeneic murine hepatoma cells bearing features of human HCC for rapid anti-HCC drug screening

Autor: Niklas Choteschovsky, Adrian Klefenz, JU Marquardt, D Castven, Leonard Kaps, Detlef Schuppan, MA Khan

Publikováno v: Zeitschrift für Gastroenterologie.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a9f3f61c9d9044bf62ed1c81291318f8
https://doi.org/10.1055/s-0039-3402238

In Vivo siRNA Delivery to Immunosuppressive Liver Macrophages by alpha-Mannosyl-Functionalized Cationic Nanohydrogel Particles

Autor: Lutz Nuhn, Nadine Leber, Leonard Kaps, Niklas Choteschovsky, Detlef Schuppan, Adrian Klefenz, Rudolf Zentel

Publikováno v: Cells
Volume 9
Issue 8
Cells, Vol 9, Iss 1905, p 1905 (2020)

Macrophages are the front soldiers of the innate immune system and are vital for immune defense, tumor surveillance, and tissue homeostasis. In chronic diseases, including cancer and liver fibrosis, macrophages can be forced into an immunosuppressive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdd63ab3572db42883f0d1c6b64264f7
https://hdl.handle.net/21.11116/0000-0007-03FC-A21.11116/0000-0006-EE0C-2

Nanoparticular bisphosphonate induces an anti-fibrotic response by modulation of fibrosis associated genes and pathways in (non-) parenchymal liver cells in CCL4 fibrotic mice

Autor: Leonard Kaps, Lutz Nuhn, Niklas Choteschovsky, Friedrich Foerster, Mustafa Diken, Adrian Klefenz, Detlef Schuppan

Publikováno v: Journal of Hepatology. 73:S519

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5330480a7546069bb12794eb70b35335
https://doi.org/10.1016/s0168-8278(20)31515-4