Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Niklas, Schwarz"'
Autor:
Sofia Nevelchuk, Bianca Brawek, Niklas Schwarz, Ariel Valiente-Gabioud, Thomas V. Wuttke, Yury Kovalchuk, Henner Koch, Anke Höllig, Frederik Steiner, Katherine Figarella, Oliver Griesbeck, Olga Garaschuk
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-18 (2024)
Abstract Background Key functions of Ca2+ signaling in rodent microglia include monitoring the brain state as well as the surrounding neuronal activity and sensing the danger or damage in their vicinity. Microglial Ca2+ dyshomeostasis is a disease ha
Externí odkaz:
https://doaj.org/article/f59d308c1bb54804afb0a503847e6608
Autor:
Simone Seiffert, Manuela Pendziwiat, Ulrike B. S. Hedrich, Ingo Helbig, Yvonne Weber, Niklas Schwarz
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
Recently, de novo variants in KCNC2, coding for the potassium channel subunit KV3.2, have been described as causative for various forms of epilepsy including genetic generalized epilepsy (GGE) and developmental and epileptic encephalopathy (DEE). Her
Externí odkaz:
https://doaj.org/article/f35535cc4a4a40148a114289331ac4de
Autor:
Carolin Haag, Betül Uysal, Justus Marquetand, Heidi Löffler, Ulrike A. Mau-Holzmann, Holger Lerche, Niklas Schwarz
Publikováno v:
Stem Cell Research, Vol 67, Iss , Pp 103028- (2023)
The STX1B gene encodes the presynaptic protein syntaxin-1B, which plays a major role in regulating fusion of synaptic vesicles. Mutations in STX1B are known to cause epilepsy syndromes, such as genetic epilepsies with febrile seizures plus (GEFS+). H
Externí odkaz:
https://doaj.org/article/764c3e675c264bdb9beb40e87e09d06d
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Bacterial cell walls are the guards of cell integrity. They are composed of peptidoglycan that provides rigidity to sustain internal turgor and ensures isolation from the external environment. In addition, they harbor the enzymatic machinery to secur
Externí odkaz:
https://doaj.org/article/0cd3f10b481c4911b8a4e16c22425f33
Autor:
Simone Seiffert, Manuela Pendziwiat, Tatjana Bierhals, Himanshu Goel, Niklas Schwarz, Amelie van der Ven, Christian Malte Boßelmann, Johannes Lemke, Steffen Syrbe, Marjolein Hanna Willemsen, Ulrike Barbara Stefanie Hedrich, Ingo Helbig, Yvonne Weber
Publikováno v:
EBioMedicine, Vol 83, Iss , Pp 104234- (2022)
Summary: Objective: Fibroblast Growth Factor 12 (FGF12) may represent an important modulator of neuronal network activity and has been associated with developmental and epileptic encephalopathy (DEE). We sought to identify the underlying pathomechani
Externí odkaz:
https://doaj.org/article/9b7caa81b2d8413d952650a2d1d40fe9
Autor:
Melanie Barth, Mehtap Bacioglu, Niklas Schwarz, Renata Novotny, Janine Brandes, Marc Welzer, Sonia Mazzitelli, Lisa M. Häsler, Manuel Schweighauser, Thomas V. Wuttke, Deborah Kronenberg-Versteeg, Karina Fog, Malene Ambjørn, Ania Alik, Ronald Melki, Philipp J. Kahle, Derya R. Shimshek, Henner Koch, Mathias Jucker, Gaye Tanriöver
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-17 (2021)
Abstract Background Proteopathic brain lesions are a hallmark of many age-related neurodegenerative diseases including synucleinopathies and develop at least a decade before the onset of clinical symptoms. Thus, understanding of the initiation and pr
Externí odkaz:
https://doaj.org/article/09a2047b1a9c471c8a762f64027b5264
Autor:
Stephan Lauxmann, Lukas Sonnenberg, Nils A. Koch, Christian Bosselmann, Natalie Winter, Niklas Schwarz, Thomas V. Wuttke, Ulrike B. S. Hedrich, Yuanyuan Liu, Holger Lerche, Jan Benda, Josua Kegele
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Introduction: Among genetic paroxysmal movement disorders, variants in ion channel coding genes constitute a major subgroup. Loss-of-function (LOF) variants in KCNA1, the gene coding for KV1.1 channels, are associated with episodic ataxia type 1 (EA1
Externí odkaz:
https://doaj.org/article/20e94abcd4a240c4ab74bc5d56dc90b3
Autor:
Niklas Schwarz, Betül Uysal, Filip Rosa, Heidi Löffler, Ulrike A. Mau-Holzmann, Stefan Liebau, Holger Lerche
Publikováno v:
Stem Cell Research, Vol 33, Iss , Pp 6-9 (2018)
Mutations in the KCNA2 gene, coding for the voltage-gated K+ channel Kv1.2, can cause developmental and epileptic encephalopathies. Kv1.2 channels play an important role in the repolarization phase of an action potential in nerve cells. Here, we repr
Externí odkaz:
https://doaj.org/article/e8df33d5d55245cb92c14a2efb44965b
Autor:
Jenny Wickham, Andrea Corna, Niklas Schwarz, Betül Uysal, Nikolas Layer, Jürgen B. Honegger, Thomas V. Wuttke, Henner Koch, Günther Zeck
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Human cerebrospinal fluid (hCSF) has proven advantageous over conventional medium for culturing both rodent and human brain tissue. In addition, increased activity and synchrony, closer to the dynamic states exclusively recorded in vivo, were reporte
Externí odkaz:
https://doaj.org/article/6d543d108b6e4c88a00dafc8c533e19b
Publikováno v:
Stem Cell Research, Vol 40, Iss , Pp - (2019)
De novo mutations in the KCNA2 gene, encoding the voltage-gated potassium channel KV1.2, have been identified to cause early-onset developmental and epileptic encephalopathies (DEE). KV1.2 channels conduct delayed-rectifier type K+ currents and play
Externí odkaz:
https://doaj.org/article/c05d69d6e64e48ea8d916ae25f8c3fb9