Výsledky vyhledávání - "Nikkie F.M. Olde Loohuis"

Akademický článek

MicroRNA-137 Controls AMPA-Receptor-Mediated Transmission and mGluR-Dependent LTD

Autor: Nikkie F.M. Olde Loohuis, Wei Ba, Peter H. Stoerchel, Aron Kos, Amanda Jager, Gerhard Schratt, Gerard J.M. Martens, Hans van Bokhoven, Nael Nadif Kasri, Armaz Aschrafi

Publikováno v: Cell Reports, Vol 11, Iss 12, Pp 1876-1884 (2015)

Mutations affecting the levels of microRNA miR-137 are associated with intellectual disability and schizophrenia. However, the pathophysiological role of miR-137 remains poorly understood. Here, we describe a highly conserved miR-137-binding site wit

Externí odkaz: https://doaj.org/article/b173bf25464a43b1a00cdee002f3d635

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Novel vertebrate- and brain-specific driver of neuronal outgrowth

Autor: Bente Benedict, Sharon M. Kolk, Jiake Xu, Nick H.M. van Bakel, Theo Hafmans, Shek Man Chim, Nikkie F.M. Olde Loohuis, Eric Jansen, Gerard J.M. Martens

Publikováno v: Progress in Neurobiology, 202, 1-16
Progress in Neurobiology, 202, pp. 1-16

During the process of neuronal outgrowth, developing neurons produce new projections, neurites, that are essential for brain wiring. Here, we discover a relatively late-evolved protein that we denote Ac45-related protein (Ac45RP) and that, surprising

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::608d5c4078e6df2bac19578171a0d49d
https://pubmed.ncbi.nlm.nih.gov/33933532

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MicroRNA-338 Attenuates Cortical Neuronal Outgrowth by Modulating the Expression of Axon Guidance Genes

Autor: Julia Meinhardt, Armaz Aschrafi, Teun Klein-Gunnewiek, Aron Kos, Nikkie F.M. Olde Loohuis, Sharon M. Kolk, Gerard J.M. Martens, Hans van Bokhoven, Barry B. Kaplan

Publikováno v: Molecular Neurobiology, 54, 3439-3452
Molecular Neurobiology, 54, 5, pp. 3439-3452

Contains fulltext : 174774.pdf (Publisher’s version ) (Closed access) MicroRNAs (miRs) are small non-coding RNAs that confer robustness to gene networks through post-transcriptional gene regulation. Previously, we identified miR-338 as a modulator

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0482c2516f209c4d98e51b050683cd64
https://doi.org/10.1007/s12035-016-9925-z

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MicroRNA-181 promotes synaptogenesis and attenuates axonal outgrowth in cortical neurons

Autor: Julia Meinhardt, Armaz Aschrafi, Aron Kos, Nikkie F.M. Olde Loohuis, Hans van Bokhoven, Gerard J.M. Martens, Barry B. Kaplan

Publikováno v: Cellular and Molecular Life Sciences, 73, 18, pp. 3555-3567
Cellular and Molecular Life Sciences, 73, 3555-3567

Contains fulltext : 167330.pdf (Publisher’s version ) (Closed access) MicroRNAs (miRs) are non-coding gene transcripts abundantly expressed in both the developing and adult mammalian brain. They act as important modulators of complex gene regulator

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::706ce7e2e0d64d6ba3ac352388a5505a
https://hdl.handle.net/2066/167330

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Altered Expression of Circadian Rhythm and Extracellular Matrix Genes in the Medial Prefrontal Cortex of a Valproic Acid Rat Model of Autism

Autor: Gerard J.M. Martens, Armaz Aschrafi, Hans van Bokhoven, Nikkie F.M. Olde Loohuis, Barry B. Kaplan, Judith R. Homberg

Publikováno v: Progress in Neuro-Psychopharmacology and Biological Psychiatry, 77, pp. 128-132
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 77, 128-132

Contains fulltext : 174398.pdf (Publisher’s version ) (Closed access) Autism spectrum disorders (ASD) are a highly heterogeneous group of neurodevelopmental disorders caused by complex interplay between various genes and environmental factors durin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::096257020d0a9b0d9accdb4f9e7b292b
https://europepmc.org/articles/PMC5502527/

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The schizophrenia risk gene MIR137 acts as a hippocampal gene network node orchestrating the expression of genes relevant to nervous system development and function

Autor: Sébastien S. Hébert, Gerard J.M. Martens, Hans van Bokhoven, Armaz Aschrafi, Nael Nadif Kasri, Jeffrey C. Glennon, Nikkie F.M. Olde Loohuis, Barry B. Kaplan

Publikováno v: Progress in Neuro-Psychopharmacology and Biological Psychiatry, 73, pp. 109-118
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 73, 109-118

Contains fulltext : 169125.pdf (Publisher’s version ) (Closed access) MicroRNAs (miRs) are small regulatory molecules, which orchestrate neuronal development and plasticity through modulation of complex gene networks. MicroRNA-137 (miR-137) is a br

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc55e3dfe3f8f13a63d893584ea3b1c9
https://doi.org/10.1016/j.pnpbp.2016.02.009

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Experimental neuropathy increases limbic forebrain CRF

Autor: Gert Jan Scheffer, Kris Vissers, M de Reus, Tamas Kozicz, Eric W. Roubos, T. Rouwette, Wim J.J.M. Scheenen, Nikkie F.M. Olde Loohuis, Janneke Giele, J. van Egmond, P. Vanelderen

Publikováno v: European Journal of Pain. 16:61-71

Neuropathic pain is often accompanied by stress, anxiety and depression. Although there is evidence for involvement of corticotropin-releasing factor (CRF), the detailed neuronal basis of these pain-related mood alterations is unknown. This study sho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::38a7562adfcea3915fdd278f3bcae306
https://doi.org/10.1016/j.ejpain.2011.05.016

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Chromosome 1p21.3 microdeletions comprising DPYD and MIR137 are associated with intellectual disability

Autor: Hans van Bokhoven, Laurens A. M. H. Kirkels, Armaz Aschrafi, Joris Andrieux, Nikkie F.M. Olde Loohuis, Muriel Holder-Espinasse, Willy M. Nillesen, Aron Kos, Rolph Pfundt, Hanneke Rensen, Mathilde Mastebroek, Willemijn M. Wissink-Lindhout, Astrid Vallès, Marjolein C Coppens-Hofman, Ben C.J. Hamel, Marjolein H. Willemsen, Louis Vallée, Tjitske Kleefstra, Arjan P.M. de Brouwer

Publikováno v: Journal of Medical Genetics; Vol 48
Journal of Medical Genetics, 48, 12, pp. 810-818
Journal of Medical Genetics, 48, 810-818
Journal of Medical Genetics, 48(12), 810-818. BMJ Publishing Group

Contains fulltext : 96723.pdf (Publisher’s version ) (Closed access) Background MicroRNAs (miRNAs) are non-coding gene transcripts involved in post-transcriptional regulation of genes. Recent studies identified miRNAs as important regulators of lea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b72ab48db64a60d98e9fbe9130c4b8b0

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Microrna-137 controls ampa-receptor-mediated transmission and mglur-dependent ltd

Autor: Aron Kos, Peter H. Stoerchel, Amanda Jager, Nikkie F.M. Olde Loohuis, Armaz Aschrafi, Gerard J.M. Martens, Hans van Bokhoven, Gerhard Schratt, Wei Ba, Nael Nadif Kasri

Publikováno v: Cell Reports, 11, 1876-1884
Cell Reports, 11, 12, pp. 1876-84
Cell Reports, 11, 12, pp. 1876-1884
Cell Reports, 11, 1876-84
Cell Reports, Vol 11, Iss 12, Pp 1876-1884 (2015)

SummaryMutations affecting the levels of microRNA miR-137 are associated with intellectual disability and schizophrenia. However, the pathophysiological role of miR-137 remains poorly understood. Here, we describe a highly conserved miR-137-binding s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c168e2fa584fc78b5a11208a1a5ec816
http://hdl.handle.net/2066/149202

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Identification of domains within the V-ATPase accessory subunit Ac45 involved in V-ATPase transport and Ca2+-dependent exocytosis

Autor: Anthon J. M. Coenen, Gerard J.M. Martens, Nikkie F.M. Olde Loohuis, Theo Hafmans, Wim J.J.M. Scheenen, Eric Jansen, Nick H.M. van Bakel, Tim Arentsen

Publikováno v: Journal of Biological Chemistry, 287, 27537-27546
Journal of Biological Chemistry, 287, 33, pp. 27537-27546

Contains fulltext : 108205.pdf (Publisher’s version ) (Open Access) The vacuolar (H(+))-ATPase (V-ATPase) is crucial for maintenance of the acidic microenvironment in intracellular organelles, whereas its membrane-bound V(0)-sector is involved in C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::706636d904391c8fc4eac0ed1281ac5b
http://hdl.handle.net/2066/108205

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