The HIV-1 integrase-LEDGF allosteric inhibitor MUT-A: resistance profile, impairment of virus maturation and infectivity but without influence on RNA packaging or virus immunoreactivity

Autor: Céline Amadori, Yme Ubeles van der Velden, Damien Bonnard, Igor Orlov, Nikki van Bel, Erwann Le Rouzic, Laia Miralles, Julie Brias, Francis Chevreuil, Daniele Spehner, Sophie Chasset, Benoit Ledoussal, Luzia Mayr, François Moreau, Felipe García, José Gatell, Alessia Zamborlini, Stéphane Emiliani, Marc Ruff, Bruno P. Klaholz, Christiane Moog, Ben Berkhout, Montserrat Plana, Richard Benarous

Publikováno v: Retrovirology, Vol 14, Iss 1, Pp 1-17 (2017)

Abstract Background HIV-1 Integrase (IN) interacts with the cellular co-factor LEDGF/p75 and tethers the HIV preintegration complex to the host genome enabling integration. Recently a new class of IN inhibitors was described, the IN-LEDGF allosteric

Externí odkaz: https://doaj.org/article/117a4c221a9c47cda76a3b1cf36e763b

The allosteric HIV-1 integrase inhibitor BI-D affects virion maturation but does not influence packaging of a functional RNA genome.

Autor: Nikki van Bel, Yme van der Velden, Damien Bonnard, Erwann Le Rouzic, Atze T Das, Richard Benarous, Ben Berkhout

Publikováno v: PLoS ONE, Vol 9, Iss 7, p e103552 (2014)

The viral integrase (IN) is an essential protein for HIV-1 replication. IN inserts the viral dsDNA into the host chromosome, thereby aided by the cellular co-factor LEDGF/p75. Recently a new class of integrase inhibitors was described: allosteric IN

Externí odkaz: https://doaj.org/article/ad51637c88a2452e9bc6870bc98e0f98

Optimizing ATES performance by increasing warm well temperature and harvesting waste/solar heat

Autor: Alex Hockin, Nikki van Bel, Niels Hartog, Stijn Beernink, Martin Bloemendal

Aquifer Thermal Energy Storage (ATES) systems combined with a heat pump stores and thereby reduces energy use for space heating and cooling of buildings. In most countries, the temperature of the stored heat is limited to maximum 25-30°C for such sy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::336f78eab13eb4e1329a5b93e6e58a09
https://doi.org/10.5194/egusphere-egu21-3481

The HIV-1 integrase-LEDGF allosteric inhibitor MUT-A: resistance profile, impairment of virus maturation and infectivity but without influence on RNA packaging or virus immunoreactivity

Autor: François Moreau, Sophie Chasset, Felipe García, Marc Ruff, Ben Berkhout, Erwann Le Rouzic, Danièle Spehner, Benoit Ledoussal, Laia Miralles, Stéphane Emiliani, Francis Chevreuil, Igor Orlov, Alessia Zamborlini, Christiane Moog, Julie Brias, Bruno P. Klaholz, Nikki van Bel, Céline Amadori, José M. Gatell, Damien Bonnard, Luzia Mayr, Yme U. van der Velden, Richard Benarous, Montserrat Plana

Publikováno v: Retrovirology, Vol 14, Iss 1, Pp 1-17 (2017)
Retrovirology
Retrovirology, BioMed Central, 2016, 14 (1), pp.50. ⟨10.1186/s12977-017-0373-2⟩
Retrovirology, BioMed Central, 2017, 14 (1), pp.50. ⟨10.1186/s12977-017-0373-2⟩
Retrovirology, 2017, 14 (1), pp.50. ⟨10.1186/s12977-017-0373-2⟩
Retrovirology, 14(1). BioMed Central

Background HIV-1 Integrase (IN) interacts with the cellular co-factor LEDGF/p75 and tethers the HIV preintegration complex to the host genome enabling integration. Recently a new class of IN inhibitors was described, the IN-LEDGF allosteric inhibitor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbc473e1572ad14a16736c21ed24232c
http://link.springer.com/article/10.1186/s12977-017-0373-2

A Short Sequence Motif in the 5 ' Leader of the HIV-1 Genome Modulates Extended RNA Dimer Formation and Virus Replication

Autor: Ben Berkhout, Atze T. Das, Marion Cornelissen, Truus E.M. Abbink, Nikki van Bel

Publikováno v: Journal of Biological Chemistry, 289(51), 35061-35074. American Society for Biochemistry and Molecular Biology Inc.
van Bel, N, Das, A T, Cornelissen, M, Abbink, G E M & Berkhout, B 2014, ' A Short Sequence Motif in the 5 ' Leader of the HIV-1 Genome Modulates Extended RNA Dimer Formation and Virus Replication ', Journal of Biological Chemistry, vol. 289, no. 51, pp. 35061-35074 . https://doi.org/10.1074/jbc.M114.621425
Journal of biological chemistry, 289(51), 35061-35074. American Society for Biochemistry and Molecular Biology Inc.

The 5' leader of the HIV-1 RNA genome encodes signals that control various steps in the replication cycle, including the dimerization initiation signal (DIS) that triggers RNA dimerization. The DIS folds a hairpin structure with a palindromic sequenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bc1f7c8be3bcc09770b1dbd84f4585b
https://research.vu.nl/en/publications/32adbe92-1365-491f-8a88-0479f490ccc9