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Autor:
Wendy Y.L. Zhang, Chien Tei Too, Shubhita Tripathi, Nikki Ya Ling Tan, Stephan Gasser, Manuel Adrian Suter, Veronique Angeli, Muznah Khatoo, Paul A. MacAry
Publikováno v:
Cancer Immunology Research. 7:B189-B189
Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a cytosolic DNA sensor that catalyses the synthesis of cGAMP, which serves as a ligand for stimulator of interferon (IFN) genes (STING). Activation of STING results in production of type I IFNs through phosph