Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Nikki T. Sawyer"'
Autor:
Nikki T. Sawyer, Ashley Helvig, Christopher D. Makinson, Gretchen N. Neigh, Andrew Escayg, Michael J. Decker
Publikováno v:
Genes, Brain and Behavior. 15:335-347
Mutations in the voltage-gated sodium channel gene SCN1A are responsible for a number of epilepsy disorders, including genetic epilepsy with febrile seizures plus (GEFS+) and Dravet syndrome. In addition, dysfunction in SCN1A is increasingly being li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::880bb5a82690db63357d0903587f6279
https://doi.org/10.1111/gbb.12281
https://doi.org/10.1111/gbb.12281
Autor:
Karin Borges, Stacey B. B. Dutton, Franck Kalume, Nikki T. Sawyer, William A. Catterall, Patricia Jumbo-Lucioni, Andrew Escayg
Publikováno v:
Epilepsia. 52:2050-2056
Purpose We evaluated the ability of the ketogenic diet (KD) to improve thresholds to flurothyl-induced seizures in two mouse lines with Scn1a mutations: one that models Dravet syndrome (DS) and another that models genetic (generalized) epilepsy with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eec47a693d8bb99f718a32f5d2b847f2
https://doi.org/10.1111/j.1528-1167.2011.03211.x
https://doi.org/10.1111/j.1528-1167.2011.03211.x
Autor:
Ligia A. Papale, Joseph R. Manns, Nikki T. Sawyer, Andrew Escayg, Ketema N. Paul, Sergio Tufik
Publikováno v:
Journal of Biological Chemistry. 285:16553-16561
Voltage-gated sodium channels (VGSCs) are responsible for the initiation and propagation of transient depolarizing currents and play a critical role in the electrical signaling between neurons. A null mutation in the VGSC gene SCN8A, which encodes th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ff06dcb9d647fce2e8662104790b469
https://doi.org/10.1074/jbc.m109.090084
https://doi.org/10.1074/jbc.m109.090084
Publikováno v:
Psychoneuroendocrinology. 39
Stress is known to trigger seizures in patients with epilepsy, highlighting the physiological stress response as a possible therapeutic target for epilepsy treatment. Nevertheless, little is currently known about how a genetic predisposition to epile
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a39d005a67c9b99f1fccfd2581f5501c
https://pubmed.ncbi.nlm.nih.gov/24138934
https://pubmed.ncbi.nlm.nih.gov/24138934
Autor:
David Weinshenker, Nikki T. Sawyer, Ligia A. Papale, Ryan H. Purcell, Andrew Escayg, Christopher D. Makinson, Jason P. Schroeder
Publikováno v:
Psychopharmacology. 228(2)
High doses of cocaine can elicit seizures in humans and in laboratory animals. Several mechanisms have been proposed for the induction of seizures by cocaine, including enhanced monoaminergic signaling, blockade of ion channels, and alterations in GA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b885b7e35ba91a1fff8455d7572a34b
https://pubmed.ncbi.nlm.nih.gov/23494229
https://pubmed.ncbi.nlm.nih.gov/23494229
Autor:
Stacey B B, Dutton, Nikki T, Sawyer, Franck, Kalume, Patricia, Jumbo-Lucioni, Karin, Borges, William A, Catterall, Andrew, Escayg
Publikováno v:
Epilepsia. 52(11)
We evaluated the ability of the ketogenic diet (KD) to improve thresholds to flurothyl-induced seizures in two mouse lines with Scn1a mutations: one that models Dravet syndrome (DS) and another that models genetic (generalized) epilepsy with febrile
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c10024654580237c4c3d96b5b50935e4
https://pubmed.ncbi.nlm.nih.gov/21801172
https://pubmed.ncbi.nlm.nih.gov/21801172
Autor:
Andrew Escayg, Nikki T. Sawyer
Publikováno v:
Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society. 27(6)
Human studies show a link between stress and epilepsy, with stress causing an increase in seizure frequency and severity in patients with epilepsy. Many different animal model systems have been used to better understand this connection and the possib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae605812a63e21eb3976c073d9479f29
https://pubmed.ncbi.nlm.nih.gov/21076337
https://pubmed.ncbi.nlm.nih.gov/21076337
Autor:
Nikki T Sawyer, Kai M. McCormack, Xiaoping Hu, Brittany R. Howell, Alison P. Grand, Dario Maestripieri, Xiaodong Zhang, Mar M. Sanchez
Publikováno v:
Biology of Mood & Anxiety Disorders
Background Early adverse experiences, especially those involving disruption of the mother-infant relationship, are detrimental for proper socioemotional development in primates. Humans with histories of childhood maltreatment are at high risk for dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e2bf5485d8f8a3b9f20dcacc23d2a44
http://europepmc.org/articles/PMC3880213
http://europepmc.org/articles/PMC3880213