Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Nikki L Jernigan"'
Publikováno v:
Pulmonary Circulation, Vol 10 (2020)
Enhanced vasoconstriction is increasingly identified as an important contributor to the development of pulmonary hypertension. Chronic hypoxia results in enhanced Rho kinase mediated Ca 2+ sensitization contributing to pressure-dependent pulmonary ar
Externí odkaz:
https://doaj.org/article/1d497bde4b90429c99f2515b787f28d8
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0236288 (2020)
Although voltage-gated Ca2+ channels (VGCC) are a major Ca2+ entry pathway in vascular smooth muscle cells (VSMCs), several other Ca2+-influx mechanisms exist and play important roles in vasoreactivity. One of these is store-operated Ca2+ entry (SOCE
Externí odkaz:
https://doaj.org/article/afaad2b83bb94e99977fb4948228cc75
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0192724 (2018)
Previous reports indicate roles for acid-sensing ion channels (ASICs) in both peripheral and central chemoreception, but the contributions of ASICs to ventilatory drive in conscious, unrestrained animals remain largely unknown. We tested the hypothes
Externí odkaz:
https://doaj.org/article/3ee4d762e7b34649b50fc2ab7aff8f5d
Autor:
Nikki L Jernigan, Jay S Naik, Laura Weise-Cross, Neil D Detweiler, Lindsay M Herbert, Tracylyn R Yellowhair, Thomas C Resta
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0180455 (2017)
Pulmonary arterial hypertension is associated with a decreased antioxidant capacity. However, neither the contribution of reactive oxygen species to pulmonary vasoconstrictor sensitivity, nor the therapeutic efficacy of antioxidant strategies in this
Externí odkaz:
https://doaj.org/article/1a2e75e75e8248a18fdc9866cb7f85e6
Publikováno v:
Antioxidants, Vol 12, Iss 12, p 2060 (2023)
Pulmonary hypertension (PH) resulting from chronic hypoxia (CH) occurs in patients with chronic obstructive pulmonary diseases, sleep apnea, and restrictive lung diseases, as well as in residents at high altitude. Previous studies from our group and
Externí odkaz:
https://doaj.org/article/80851efd2c6d4328a087ad51bae05ad4
Autor:
Selina M. Garcia, Tracy R. Yellowhair, Neil D. Detweiler, Rosstin Ahmadian, Lindsay M. Herbert, Laura V. Gonzalez Bosc, Thomas C. Resta, Nikki L. Jernigan
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Acid-sensing ion channel 1a (ASIC1a) is a voltage-independent, non-selective cation channel that conducts both Na+ and Ca2+. Activation of ASIC1a elicits plasma membrane depolarization and stimulates intracellular Ca2+-dependent signaling pathways in
Externí odkaz:
https://doaj.org/article/5b0acd1eae6c415191754f383d469cd3
Autor:
Selina M. Garcia, Benjamin Matheson, Juan H. Morales-Loredo, Nikki L. Jernigan, Nancy L. Kanagy, Thomas C. Resta, Ross M. Clark, Reza Shekarriz, Laura V. Gonzalez Bosc
Publikováno v:
American journal of physiology. Regulatory, integrative and comparative physiology. 323(6)
Hypoxia is the reduction of alveolar partial pressure of oxygen ([Formula: see text]). Military members and people who practice recreational activities from moderate to high altitudes are at risk for hypoxic exposure. Hypoxemia’s signs and symptoms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca41a08fde734aa2534edc783b7b5b75
https://pubmed.ncbi.nlm.nih.gov/36250874
https://pubmed.ncbi.nlm.nih.gov/36250874
Autor:
Levi D. Maston, David T. Jones, Wieslawa Giermakowska, Thomas C. Resta, Juan Ramiro-Diaz, Tamara A. Howard, Nikki L. Jernigan, Lindsay Herbert, Anna A. Maurice, Laura V. Gonzalez Bosc
Publikováno v:
Pulmonary Circulation, Vol 8 (2018)
Interleukin-6 (IL-6) is a pleotropic cytokine that signals through the membrane-bound IL-6 receptor (mIL-6R) to induce anti-inflammatory (“classic-signaling”) responses. This cytokine also binds to the soluble IL-6R (sIL-6R) to promote inflammati
Externí odkaz:
https://doaj.org/article/ce35d513a180422e9248b38507a63b49
Publikováno v:
J Physiol
Pulmonary hypertension is characterized by sustained vasoconstriction and remodelling of the small pulmonary arteries, which is associated with persistent depolarization of the resting membrane potential (Em ) of pulmonary arterial smooth muscle cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7493d0c0e65bc442572fc39f675be00
https://doi.org/10.1113/jp282231
https://doi.org/10.1113/jp282231
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::846efd226ed3bbc7d2f09c08e06251e8
https://doi.org/10.1096/fasebj.2022.36.s1.r2480
https://doi.org/10.1096/fasebj.2022.36.s1.r2480