Prophylactic radiotherapy for the prevention of procedure-tract metastases after surgical and large-bore pleural procedures in malignant pleural mesothelioma (SMART): a multicentre, open-label, phase 3, randomised controlled trial

Autor: N. Panakis, M. Button, James Gildersleve, Y. C. Gary Lee, Emma De Winton, Muthukumar Dakshinamoorthy, Anthony L Kerry, Samuel A. Stewart, Anna J Morley, J Pepperell, Lee Dobson, Timothy J.P. Batchelor, Samantha Cooper, Conrad R. Lewanski, Alina Ionescu, Erika Penz, Natalie Zahan-Evans, Peter Jenkins, Hazel Taylor, Timothy Howell, Charles Comins, Adrian Marchbank, M. Bayne, Nick A Maskell, Fiona McDonald, Vallipuram Vigneswaran, Najib M. Rahman, Elizabeth Toy, Lesley Bishop, Sarah Smith, Merina Ahmed, P. T. Wilson, Amelia O Clive, Nikki Jordan

Publikováno v: Clive, A O, Taylor, H, Dobson, L, Wilson, P, de Winton, E, Panakis, N, Pepperell, J C T, Howell, T, Stewart, S A, Penz, E, Jordan, N, Morley, A J, Zahan-Evans, N, Smith, S, Batchelor, T J P, Marchbank, A, Bishop, L, Ionescu, A A, Bayne, M, Cooper, S, Kerry, A L, Jenkins, P, Toy, E, Vigneswaran, V, Gildersleve, J, Ahmed, M, McDonald, F, Button, M, Lewanski, C, Comins, C, Dakshinamoorthy, M, Lee, Y C G, Rahman, N M & Maskell, N A 2016, ' Prophylactic radiotherapy for the prevention of procedure-tract metastases after surgical and large-bore pleural procedures in malignant pleural mesothelioma (SMART) : a multicentre, open-label, phase 3, randomised controlled trial ' The Lancet Oncology, vol 17, no. 8, pp. 1094-1104 . DOI: 10.1016/S1470-2045(16)30095-X
Clive, A O, Taylor, H, Dobson, L, Wilson, P, de Winton, E, Panakis, N, Pepperell, J C T, Howell, T, Stewart, S A, Penz, E, Jordan, N, Morley, A J, Zahan-Evans, N, Smith, S, Batchelor, T J P, Marchbank, A, Bishop, L, Ionescu, A A, Bayne, M, Cooper, S, Kerry, A L, Jenkins, P, Toy, E, Vigneswaran, V, Gildersleve, J, Ahmed, M, McDonald, F, Button, M, Lewanski, C, Comins, C, Dakshinamoorthy, M, Lee, Y C G, Rahman, N M & Maskell, N A 2016, ' Prophylactic radiotherapy for the prevention of procedure-tract metastases after surgical and large-bore pleural procedures in malignant pleural mesothelioma (SMART) : a multicentre, open-label, phase 3, randomised controlled trial ', Lancet Oncology, vol. 17, no. 8, pp. 1094-1104 . https://doi.org/10.1016/S1470-2045(16)30095-X

BackgroundThe use of prophylactic radiotherapy to prevent procedure-tract metastases (PTMs) in malignant pleural mesothelioma remains controversial, and clinical practice varies worldwide. We aimed to compare prophylactic radiotherapy with deferred r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1bb10a2e1e402c1e5138b34e6a75fd4
https://doi.org/10.1016/s1470-2045(16)30095-x

Specialist palliative care, psychology, interstitial lung disease (ILD) multidisciplinary team meeting: a novel model to address palliative care needs

Autor: Clare Kendall, Michelle Morales, Nikki Jordan, Toby Speirs, Charles Sharp, A. S. G. Edwards, Sarah Mulholland, Shaney L Barratt, Rachel Gunary, Khaled Al Jboor, Patricia Meek, Heather Lamb, Huzaifa Adamali

Publikováno v: BMJ Open Respiratory Research

IntroductionPatients with progressive idiopathic fibrotic interstitial lung disease (ILD), such as those with idiopathic pulmonary fibrosis (IPF), can have an aggressive disease course, with a median survival of only 3–5 years from diagnosis. The p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13017beab0277931c5d16f81c2ea642f
https://doi.org/10.1136/bmjresp-2018-000360

Effect of different cooking regimes on rhubarb polyphenols

Autor: Pat Dobson, Nikki Jordan-Mahy, Gordon J. McDougall

Publikováno v: Food Chemistry. 119:758-764

Polyphenolic components, such as anthraquinones and stilbenes, from species of the genus Rheum have been shown to have a range of bioactivities relevant to human health. This paper outlines the polyphenolic composition of edible petioles of garden rh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf20912dd0d0d13422347faa27fbc1be
https://doi.org/10.1016/j.foodchem.2009.07.030

Issues in prognostication for hospital specialist palliative care doctors and nurses: a qualitative inquiry

Autor: Nikki Jordan, David Pontin

Publikováno v: Palliative medicine. 27(2)

Background: Patients with advanced life-limiting diseases have high information needs concerning prognosis yet discussions between patients and healthcare professionals are either avoided or inaccurate due to over-optimism. Available prognostic model

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03db6e3b4f83da7340772863d4022934
https://pubmed.ncbi.nlm.nih.gov/22190605

Protocol for the surgical and large bore procedures in malignant pleural mesothelioma and radiotherapy trial (SMART Trial): an RCT evaluating whether prophylactic radiotherapy reduces the incidence of procedure tract metastases

Autor: N. Panakis, Amelia O Clive, Nikki Jordan, J Pepperell, Y. C. Gary Lee, Anna J Morley, Timothy J.P. Batchelor, Najib M. Rahman, P. T. Wilson, Lee Dobson, Timothy Howell, Hazel Taylor, Emma De Winton, Nick A Maskell

Publikováno v: BMJ Open

Introduction Patients with malignant pleural mesothelioma (MPM) may develop painful ‘procedure tract metastasis’ (PTM) at the site of previous pleural interventions. Prophylactic radiotherapy has been used to minimise this complication; however,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::536cb300815b8f7cfb73990b5a900dc2
https://doi.org/10.1136/bmjopen-2014-006673