Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Nikita V. Shtyrlin"'
Autor:
Nikita V. Shtyrlin, Mikhail V. Pugachev, Sergey V. Sapozhnikov, Marsel R. Garipov, Rusalia M. Vafina, Denis Y. Grishaev, Roman S. Pavelyev, Renata R. Kazakova, Mariya N. Agafonova, Alfiya G. Iksanova, Svetlana A. Lisovskaya, Marina I. Zeldi, Elena S. Krylova, Elena V. Nikitina, Alina E. Sabirova, Airat R. Kayumov, Yurii G. Shtyrlin
Publikováno v:
Molecules, Vol 25, Iss 18, p 4341 (2020)
A series of 108 novel quaternary bis-ammonium pyridoxine derivatives carrying various substituents at the quaternary nitrogen’s and acetal carbon was synthesized. Thirteen compounds exhibited antibacterial and antifungal activity (minimum inhibitor
Externí odkaz:
https://doaj.org/article/3173c442871045d0a08a8fd0266eb676
Autor:
Rail M. Khaziev, Konstantin S. Usachev, Alexander E. Klimovitskii, Nikita V. Shtyrlin, Edward M. Gilyazetdinov, Yurii G. Shtyrlin, Petr Yablonskiy, Mariya N. Agafonova, E. G. Sokolovich, Tatiana Vinogradova, Daut R. Islamov, Natalia Zabolotnykh, Marine Dogonadze, Valery G. Shtyrlin
Publikováno v:
Medicinal Chemistry Research. 30:952-963
A series of novel isonicotinoyl hydrazones based on pyridoxine (vitamin B6) were synthesized. The synthesized compounds were evaluated for their antimycobacterial activity on M. tuberculosis H37Rv strain. The most potent compound 13 showed good activ
Publikováno v:
Chimica Techno Acta; Том 7, № 4 (2020): MOSM2020 Special Issue; 159-168
Chimica Techno Acta, Vol 7, Iss 4, Pp 159-168 (2020)
Chimica Techno Acta, Vol 7, Iss 4, Pp 159-168 (2020)
Received: 15.10.2020. Accepted: 09.12.2020. Published:30.12.2020. In this work we describe the transformation of synthetic route of the antiepileptic drug candidate Sumepirin starting from discovery stage. Initial method included six step process req
Autor:
Raylya R. Gabbasova, Roman S. Pavelyev, Denis Yu. Grishaev, Anastasia V. Galochkina, Raushan Nigmatullin, Petr Yablonskiy, Konstantin V. Balakin, Rail M. Khaziev, Olga Manicheva, Tatiana Vinogradova, Anna A. Shtro, Yulia V. Nikolaeva, Marine Dogonadze, Oleg Gnezdilov, E. G. Sokolovich, Yurii G. Shtyrlin, Nikita V. Shtyrlin
Publikováno v:
Letters in Drug Design & Discovery. 16:1360-1369
Background: Adamantane derivatives possess multiple pharmacological activities such as antiviral, anticancer, antimycobacterial, antidiabetic, antiparkinsonian and others. The interest of medicinal chemists in adamantane compounds is due to their uni
Autor:
A. Kayumov, Alfiya G. Iksanova, S. Sapozhnikov, M. Agafonova, Yurii G. Shtyrlin, M. Garipov, Mikhail V. Pugachev, R. Khaziev, Nikita V. Shtyrlin
Publikováno v:
материалы конференции.
Autor:
Mikhail V. Pugachev, Roman S. Pavelyev, Konstantin V. Balakin, Nikita V. Shtyrlin, A. S. Petukhov, Marsel R. Garipov, Alfiya G. Iksanova, Mikhail S. Dzyurkevich, Yurii G. Shtyrlin, A. D. Strel’nik
Publikováno v:
Russian Chemical Bulletin. 68:911-945
Pyridoxine and its derivatives, pyridoxamine and pyridoxal, are the three main forms of vitamin B6, which play exceptionally important biological roles in living organisms. The active endogenous metabolites of these molecules, pyridoxal phosphate and
Autor:
Airat R. Kayumov, Roman S. Pavelyev, Mikhail I. Bogachev, Nikita V. Shtyrlin, Marsel R. Garipov, Alina E. Sabirova, Aleksandr V. Laikov, Oksana V. Bondar, Julia Romanova, Svetlana A. Lisovskaya, Yurii G. Shtyrlin
Publikováno v:
Bioorganic chemistry. 104
Many pathogenic bacteria and microscopic fungi form rigid polymicrobial biofilms this way enhancing their resistant to treatment. A series of novel pyridoxine-based quaternary ammonium derivatives of terbinafine characterized by both antifungal and a
Autor:
Konstantin V. Balakin, Marina I. Zeldi, Denis Yu. Grishaev, O. I. Gnezdilov, Arthur A. Grigor’ev, Raylya R. Gabbasova, Yurii G. Shtyrlin, Oleg E. Nasakin, Nikita V. Shtyrlin
Publikováno v:
Synthetic Communications. 48:2288-2304
A library of 29 2-amino-6-sulfanylpyridine-3,5-dicarbonitriles functionalized with a pyridoxine moiety was synthesized using a three-component one-pot reaction of aldehyde derivative of pyridoxine,...
Autor:
Michail V. Pugachev, Tatyana V. Kupriyanova, Konstantin V. Balakin, Almaz A. Akhunzyanov, Alfiya G. Iksanova, Nikita V. Shtyrlin, Yurii G. Shtyrlin, Ruzalia M. Vafiva, Raylya R. Gabbasova
Publikováno v:
Anti-Cancer Drugs. 29:682-690
This work presents the results of in-vitro biological activity studies of three novel anticancer agents, phosphonium salts based on the 3-hydroxypyridine scaffold, including one derivative of 4-deoxypyridoxine. Proliferation and viability of cells tr
Autor:
Nikita V. Shtyrlin, Yu. G. Shtyrlin, Konstantin V. Balakin, A. P. Alekseev, Olga A. Lodochnikova, N. V. Volobueva, E. I. Romanova, Rail M. Khaziev, R. V. Chestnova
Publikováno v:
Russian Journal of Organic Chemistry. 54:426-430
Pyridoxine derivatives, 3-hydroxy-2-methylpyridine-4- and -5-carbohydrazides, were synthesized according to optimized known procedures, and a method for the synthesis of 5-(hydroxymethyl)-2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridine-6-carbohydrazid