Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Nikita V. Khotskin"'
TAD border deletion at the Kit locus causes tissue-specific ectopic activation of a neighboring gene
Autor:
Evelyn Kabirova, Anastasiya Ryzhkova, Varvara Lukyanchikova, Anna Khabarova, Alexey Korablev, Tatyana Shnaider, Miroslav Nuriddinov, Polina Belokopytova, Alexander Smirnov, Nikita V. Khotskin, Galina Kontsevaya, Irina Serova, Nariman Battulin
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Topologically associated domains (TADs) restrict promoter-enhancer interactions, thereby maintaining the spatiotemporal pattern of gene activity. However, rearrangements of the TADs boundaries do not always lead to significant changes in the
Externí odkaz:
https://doaj.org/article/15cb7925751a4aab881fdbd3b131169d
Autor:
Alla B. Arefieva, Polina D. Komleva, Vladimir S. Naumenko, Nikita V. Khotskin, Alexander V. Kulikov
Publikováno v:
Biomolecules, Vol 13, Iss 10, p 1458 (2023)
Tryptophan hydroxylase 2 (TPH2) is the key and rate-limiting enzyme of serotonin (5-HT) synthesis in the mammalian brain. The 1473G mutation in the Tph2 gene decreases TPH2 activity in the mouse brain by twofold. (R)-2-amino-6-(1R, 2S)-1,2-dihydroxyp
Externí odkaz:
https://doaj.org/article/b2c1e9d68d274960ad626e32e0e507a4
Autor:
Polyna D. Komleva, Ghofran Alhalabi, Arseniy E. Izyurov, Nikita V. Khotskin, Alexander V. Kulikov
Publikováno v:
Biomolecules, Vol 13, Iss 6, p 963 (2023)
Tryptophan hydroxylase 2 (TPH2) is the key and rate-limited enzyme of serotonin (5-HT) synthesis in the brain. The C1473G mutation in the Tph2 gene results in a two-fold decrease in enzyme activity in the mouse brain. The lethal yellow (AY) mutation
Externí odkaz:
https://doaj.org/article/e69afe9657704615a79ec0264f8e17a8
Autor:
Enrico Ullmann, Seth W. Perry, Julio Licinio, Ma-Li Wong, Eliyahu Dremencov, Evgenii L. Zavjalov, Oleg B. Shevelev, Nikita V. Khotskin, Galina V. Koncevaya, Anna S. Khotshkina, Mikhail P. Moshkin, Maxim S. Lapshin, Maria V. Komelkova, Inna V. Feklicheva, Olga B. Tseilikman, Olga P. Cherkasova, Kamaldeep S. Bhui, Edgar Jones, Clemens Kirschbaum, Stefan R. Bornstein, Vadim Tseilikman
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 13 (2019)
The concepts of allostatic load and overload, i. e., a dramatic increase in the allostatic load that predisposes to disease, have been extensively described in the literature. Here, we show that rats engaging in active offensive response (AOR) behavi
Externí odkaz:
https://doaj.org/article/6d0c416bb24340de86eb61bd8e4bf402
Autor:
Nikita V. Khotskin, Arseniy E. Izyurov, Alexandra V. Plyusnina, Elizabeth A. Kulikova, Alexander V. Kulikov
Publikováno v:
Current Protein & Peptide Science. 24:329-338
Background: The brain melanocortin system regulates numerous physiological functions and kinds of behavior. The agouti protein inhibits melanocortin receptors in melanocytes. The lethal yellow (AY) mutation puts the Agouti gene under the control of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eae09dd113868019e5c19084896b6d80
https://doi.org/10.2174/1389203724666230320145556
https://doi.org/10.2174/1389203724666230320145556
Autor:
Kulikov, Polyna D. Komleva, Ghofran Alhalabi, Arseniy E. Izyurov, Nikita V. Khotskin, Alexander V.
Publikováno v:
Biomolecules; Volume 13; Issue 6; Pages: 963
Tryptophan hydroxylase 2 (TPH2) is the key and rate-limited enzyme of serotonin (5-HT) synthesis in the brain. The C1473G mutation in the Tph2 gene results in a two-fold decrease in enzyme activity in the mouse brain. The lethal yellow (AY) mutation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::89f8688043aea2cc27dcb9f91d648be9
Autor:
Darya Bazovkina, Nina B. Illarionova, Elizabeth A. Kulikova, Ekaterina Yu. Bazhenova, Nadezhda A. Sinyakova, Nikita V. Khotskin, Sergey Nikitin, Vasily S. Lankin, Elena E. Terenina, Oleg V. Trapezov, Aleksandr V. Kulikov
Publikováno v:
Brain, Behavior and Evolution.
Here, we present the first evidence for brain adaptation in pigs tolerant to the human presence, as a behavioral trait favoring domestication. The study was carried out on minipiglets from population bred in the Institute of Cytology and Genetics (No
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af472e5f258f11fd0a3c25ab159ff502
https://doi.org/10.1159/000530116
https://doi.org/10.1159/000530116
Autor:
Elena M, Kondaurova, Irina I, Belokopytova, Elisabeth A, Kulikova, Nikita V, Khotskin, Tatiana V, Ilchibaeva, Anton S, Tsybko, Nina K, Popova, Vladimir S, Naumenko
Publikováno v:
Behavioural brain research. 438
Autism spectrum disorders (ASDs) are some of the most common neurodevelopmental disorders; however, the mechanisms underlying ASDs are still poorly understood. Serotonin (5-HT) and brain-derived neurotrophic factor (BDNF) are known as key players in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::387f27d3924f239111ebe4dda4a679d0
https://pubmed.ncbi.nlm.nih.gov/36280010
https://pubmed.ncbi.nlm.nih.gov/36280010
Autor:
Elena M. Kondaurova, Irina I. Belokopytova, Elisabeth A. Kulikova, Nikita V. Khotskin, Tatiana V. Ilchibaeva, Anton S. Tsybko, Nina K. Popova, Vladimir S. Naumenko
Publikováno v:
Behavioural Brain Research. 438:114168
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d1b4546dbce6084a1666f340de1d9af
https://doi.org/10.1016/j.bbr.2022.114168
https://doi.org/10.1016/j.bbr.2022.114168
Publikováno v:
Neuroscience and Behavioral Physiology. 50:192-198
Seasonal depressive disorder occurs in conditions of seasonal reductions in the duration of daylight and is a significant medical, social, and economic problem. The risk of seasonal depressive disorders is linked with impairments to the serotonin sys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::177dcba57d94cea2bd95324914d62ad6
https://doi.org/10.1007/s11055-019-00887-w
https://doi.org/10.1007/s11055-019-00887-w