Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Nikita S. Sharma"'
Autor:
Patricia Dauer, Nikita S. Sharma, Vineet K. Gupta, Alice Nomura, Vikas Dudeja, Ashok Saluja, Sulagna Banerjee
Publikováno v:
Molecular Oncology, Vol 12, Iss 9, Pp 1498-1512 (2018)
Chemoresistance is a major therapeutic challenge that plays a role in the poor statistical outcomes in pancreatic cancer. Unfolded protein response (UPR) is one of the homeostasis mechanisms in cancer cells that have been correlated with chemoresista
Externí odkaz:
https://doaj.org/article/b993b2be4428425c9cc80b5a2434ded1
Autor:
Patricia Dauer, Vineet K. Gupta, Olivia McGinn, Alice Nomura, Nikita S. Sharma, Nivedita Arora, Bhuwan Giri, Vikas Dudeja, Ashok K. Saluja, Sulagna Banerjee
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract Endoplasmic reticulum (ER) stress initiates an important mechanism for cell adaptation and survival, named the unfolded protein response (UPR). Severe or chronic/prolonged UPR can breach the threshold for survival and lead to cell death. The
Externí odkaz:
https://doaj.org/article/e14646c77c0341be9bc1d51784fe5589
Autor:
Sulagna Banerjee, Pankaj K. Singh, Ashok Saluja, Sanjoy K. Bhattacharya, Zhen Gao, Yuguang Ban, Sai Sundeep Kollala, Beatriz Mateo-Victoriano, Ciara Myer, Dezhen Wang, Dujon Edwards, Kousik Kesh, Vanessa T. Garrido, Brittany Durden, Nikita S. Sharma, Vineet K. Gupta
In pancreatic cancer, the robust fibroinflammatory stroma contributes to immune suppression and renders tumors hypoxic, altering intratumoral metabolic pathways and leading to poor survival. One metabolic enzyme activated during hypoxia is lactate de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aac7499a6b2067935be1477a4c02d2a8
https://doi.org/10.1158/0008-5472.c.6513001
https://doi.org/10.1158/0008-5472.c.6513001
Autor:
Sulagna Banerjee, Pankaj K. Singh, Ashok Saluja, Sanjoy K. Bhattacharya, Zhen Gao, Yuguang Ban, Sai Sundeep Kollala, Beatriz Mateo-Victoriano, Ciara Myer, Dezhen Wang, Dujon Edwards, Kousik Kesh, Vanessa T. Garrido, Brittany Durden, Nikita S. Sharma, Vineet K. Gupta
ITRAQ table
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::191704ec1a217e39bae5b6a2389af555
https://doi.org/10.1158/0008-5472.22428367.v1
https://doi.org/10.1158/0008-5472.22428367.v1
Autor:
Sulagna Banerjee, Pankaj K. Singh, Ashok Saluja, Sanjoy K. Bhattacharya, Zhen Gao, Yuguang Ban, Sai Sundeep Kollala, Beatriz Mateo-Victoriano, Ciara Myer, Dezhen Wang, Dujon Edwards, Kousik Kesh, Vanessa T. Garrido, Brittany Durden, Nikita S. Sharma, Vineet K. Gupta
RNA seq data file after treatment of MIA-PACA2 cells with L-2HG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0481e6067ec81058d498b63e02365323
https://doi.org/10.1158/0008-5472.22428373.v1
https://doi.org/10.1158/0008-5472.22428373.v1
Autor:
Vineet Gupta, Vanessa T. Garrido, Brittany Durden, Anthony Ferrantella, Vikas Dudeja, Ashok K. Saluja, Sulagna Banerjee, Bhuwan Giri, Kousik Kesh, Nikita S. Sharma, Roey Hadad
Publikováno v:
Journal of Clinical Investigation. 130:451-465
Pancreatic ductal adenocarcinoma (PDAC) is considered to be a highly immunosuppressive and heterogenous neoplasm. Despite improved knowledge regarding the genetic background of the tumor and better understanding of the tumor microenvironment, immune
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::338ae90d3c721c9c629aa73cbe9c14d9
https://doi.org/10.1172/jci127515
https://doi.org/10.1172/jci127515
Autor:
Nikita S. Sharma, Patricia Dauer, Sulagna Banerjee, Brittany Durden, Ashok K. Saluja, Santanu Banerjee, Roey Hadad, Vineet Gupta, Vikas Dudeja
Publikováno v:
Cell Death and Disease, Vol 10, Iss 2, Pp 1-13 (2019)
Cell Death & Disease
Cell Death & Disease
Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) signaling have been shown to be dysregulated in multiple cancer types. Glucose regulatory protein 78 (GRP78), the master regulator of the UPR, plays a role in proliferation, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f5c968b91fca23daae78ee1d39ac561
http://link.springer.com/article/10.1038/s41419-019-1408-5
http://link.springer.com/article/10.1038/s41419-019-1408-5
O-GlcNAc modification of Sox2 regulates self-renewal in pancreatic cancer by promoting its stability
Autor:
Vineet Gupta, Chad Slawson, Kousik Kesh, Nikita S. Sharma, Roey Hadad, Patricia Dauer, Santanu Banerjee, Anjali Chandra, Selwyn M. Vickers, Bhuwan Giri, Vikas Dudeja, Ashok K. Saluja, Sulagna Banerjee
Publikováno v:
Theranostics
Pancreatic adenocarcinoma (PDAC) claims more than 90% of the patients diagnosed with the disease owing to its aggressive biology that is manifested by high rate of tumor recurrence. Aberrant upregulation in the transcriptional activity of proteins in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b38082fbe1814e5a0e47726c66bd34ea
https://doi.org/10.7150/thno.32615
https://doi.org/10.7150/thno.32615
Autor:
Shrey Modi, Bhuwan Giri, Vineet K. Gupta, Shweta Lavania, Vrishketan Sethi, Nikita S. Sharma, Somnath Pandey, Selwyn Vickers, Vikas Dudeja, Ashok K. Saluja
Publikováno v:
Cancer Letters. 537:215591
Addition of nab-paclitaxel to gemcitabine offers a survival benefit of only 6 weeks over gemcitabine alone at a cost of increased toxicity in PDAC. The goal of the present study is to evaluate the efficacy of Minnelide, a water-soluble prodrug of tri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb0d8c52ff142682bd205473f67d4c73
https://doi.org/10.1016/j.canlet.2022.215591
https://doi.org/10.1016/j.canlet.2022.215591
Autor:
Sanjoy K. Bhattacharya, Kousik Kesh, Santanu Banerjee, Bhuwan Giri, Vineet Gupta, Nikita S. Sharma, Vikas Dudeja, Patricia Dauer, Sulagna Banerjee, Ashok K. Saluja, Alice Nomura
Publikováno v:
Cancer Letters. 439:101-112
Metabolic rewiring is an integral part of tumor growth. Among metabolic pathways, the Mevalonic-Acid-Pathway (MVAP) plays a key role in maintaining membrane architecture through cholesterol synthesis, thereby affecting invasiveness. In the current st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9222ff0e31d70bb9431454cde8f9008f
https://doi.org/10.1016/j.canlet.2018.09.028
https://doi.org/10.1016/j.canlet.2018.09.028