Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Nikita S. Kolhatkar"'
Autor:
Kenneth Kim, C. Josefina Martinez, Nima Aghaeepour, Nilanjan Mukherjee, Han Chen, Bonnie Bock, Neda Hajiakhoond Bidoki, Sean N. Tucker, David R. McIlwain, David Liebowitz, Jiang Sizun, Julien Hedou, Garry P. Nolan, Nikita S. Kolhatkar, Melton Affrime, Brice Gaudilliere, Zainab Rahil, Zach Bjornson, Angelica Trejo, Christian M. Schürch
Publikováno v:
Cell Host Microbe
Developing new influenza vaccines with improved performance and easier administration routes hinges on defining correlates of protection. Vaccine-elicited cellular correlates of protection for influenza in humans have not yet been demonstrated. A pha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18ccb802c6affaf4c91aa166c7326aa6
https://europepmc.org/articles/PMC8665113/
https://europepmc.org/articles/PMC8665113/
Autor:
Kenneth Kim, David Liebowitz, Keith Gottlieb, David R. McIlwain, Nikita S. Kolhatkar, Jason Asher, Shaily J Garg, Sean N. Tucker, Jonathan Nazareno
Publikováno v:
The Lancet. Infectious diseases. 20(4)
Summary Background Influenza is an important public health problem and existing vaccines are not completely protective. New vaccines that protect by alternative mechanisms are needed to improve efficacy of influenza vaccines. In 2015, we did a phase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::355ee36a0c1a16753f637984d62ec3bb
https://pubmed.ncbi.nlm.nih.gov/31978351
https://pubmed.ncbi.nlm.nih.gov/31978351
Autor:
Genita Metzler, Nicole E. Scharping, Sarah Leach, Christopher D. Thouvenel, Nikita S. Kolhatkar, Holly M. Jacobs, David J. Rawlings, Tanvi Arkatkar, Shaun W. Jackson
Publikováno v:
The Journal of Immunology. 196:3525-3531
Mice overexpressing B cell activating factor of the TNF family (BAFF) develop systemic autoimmunity characterized by class-switched anti-nuclear Abs. Transmembrane activator and CAML interactor (TACI) signals are critical for BAFF-mediated autoimmuni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4094d1bcf59ecaf987a0b2a877ec180
https://doi.org/10.4049/jimmunol.1600017
https://doi.org/10.4049/jimmunol.1600017
Publikováno v:
Current Opinion in Immunology. 37:46-53
The establishment of a diverse B cell repertoire requires fine-tuning of antigen receptor selection during development in order to permit sufficient diversity while reducing the potential for autoimmunity. In this review, we highlight recent studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fa7ac02a7108fde6755e14fe6e0da69
https://doi.org/10.1016/j.coi.2015.10.001
https://doi.org/10.1016/j.coi.2015.10.001
Autor:
Socheath Khim, Nikita S. Kolhatkar, Holly M. Jacobs, Luigi D. Notarangelo, David J. Rawlings, Troy R. Torgerson, Eric J. Allenspach, Marc A. Schwartz, Archana Brahmandam, Christopher D. Thouvenel, Anil K. Panigrahi, Adrian J. Thrasher, Shirly Becker-Herman, Eline T. Luning Prak, Ignacio Sanz, Fabio Candotti
Publikováno v:
The Journal of Experimental Medicine
Kolhatkar et al. report that altered BCR and TLR signaling orchestrates increased positive selection of transitional B cells expressing low-affinity self-reactive BCRs, leading to their enrichment within the naive B cell compartment. These findings h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::727a9fffbbed34916df0c8912f854b5a
https://doi.org/10.1084/jem.20150585
https://doi.org/10.1084/jem.20150585
Autor:
Jenna M. Sullivan, Luigi D. Notarangelo, Marc A. Schwartz, David J. Rawlings, Nicole E. Scharping, Socheath Khim, Nikita S. Kolhatkar, Holly M. Jacobs, Shaun W. Jackson, Adrian J. Thrasher
Publikováno v:
European Journal of Immunology. 45:2773-2779
Patients with Wiskott-Aldrich syndrome (WAS) exhibit prominent defects in splenic marginal zone (MZ), resulting in abnormal T-cell-independent antibody responses and increased bacterial infections. B-cell-intrinsic deletion of the affected gene WAS p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71f39f2382bf5e36eb15bc33e103133b
https://doi.org/10.1002/eji.201545644
https://doi.org/10.1002/eji.201545644
Publikováno v:
Current Opinion in Immunology. 33:70-77
A significant proportion of autoimmune-associated genetic variants are expressed in B cells, suggesting that B cells may play multiple roles in autoimmune pathogenesis. In this review, we highlight recent studies demonstrating that even modest altera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bdd4580d799086801baa217b7ac0de0
https://doi.org/10.1016/j.coi.2015.01.018
https://doi.org/10.1016/j.coi.2015.01.018
Autor:
Kassandra Kasparek, Katie A. Hodgson, Keith Gottlieb, Nikita S. Kolhatkar, David Liebowitz, Sean N. Tucker
Publikováno v:
Open Forum Infectious Diseases
Background Oral vaccines delivered as tablets offer several advantages over traditional injection-based vaccines including ease of distribution and administration as well as temperature-stable formulation options. Oral vaccination is also advantageou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36bbd44173eb4be61d6985683039c5af
http://europepmc.org/articles/PMC6253129
http://europepmc.org/articles/PMC6253129
Autor:
Roberto Mateo, Nikita S. Kolhatkar, David N. Taylor, Karen Lin, Shaily J Garg, Sean N. Tucker
Publikováno v:
Open Forum Infectious Diseases
Background Norovirus (NoV) is a common cause of acute gastroenteritis, but no vaccines are currently licensed. Vaxart is developing an oral tableted NoV vaccine that induces both systemic and mucosal immune responses. Methods Two separate clinical st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6324049ab8a3010d6060923715ff41be
https://doi.org/10.1093/ofid/ofz359.002
https://doi.org/10.1093/ofid/ofz359.002
Autor:
Xizhang Sun, Jinoh Kim, Nikita S. Kolhatkar, Edward A. Clark, Matthew B. Buechler, Craig P. Chappell, Keith B. Elkon, Lena Tanaka, Thereza Imanishi-Kari, Natalia V. Giltiay, Jessica A. Hamerman, Thomas H. Teal, Alice E. Wiedeman
Publikováno v:
The Journal of Experimental Medicine
Transgenic expression of TLR7 results in the expansion and hyperactivation of T1 B cells in response to endogenous RNA complexes, leading to increased autoantibody production.
Toll-like receptor (TLR), a ligand for single-stranded RNA, has been
Toll-like receptor (TLR), a ligand for single-stranded RNA, has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5328468f1736fcc1295756d1ad47c4db
https://doi.org/10.1084/jem.20122798
https://doi.org/10.1084/jem.20122798