Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Nikita A. Slesarchuk"'
Autor:
A A Shtro, E A Ulashchik, T D Nikitin, Alexey A. Chistov, E V Chekerda, Vadim V. Shmanai, Nikita A. Slesarchuk, Vladimir A. Korshun, Alexey V. Ustinov, A V Galochkina, Y V Nikolayeva
Publikováno v:
Russian Journal of Bioorganic Chemistry
In this work, we describe the synthesis of 5-(perylen-3-ylethynyl)uridine and its ability to effectively inhibit the replication of respiratory disease pathogens in cell culture, namely: influenza A virus (IVA); type 3 parainfluenza virus (PIV-3); an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f3a335f70332ceee3749d9e25e6f66d
http://europepmc.org/articles/PMC7305479
http://europepmc.org/articles/PMC7305479
Autor:
Alexey A. Chistov, Stepan P. Chumakov, Igor E. Mikhnovets, Timofei D. Nikitin, Nikita A. Slesarchuk, Victoria I. Uvarova, Anna A. Rubekina, Yulia V. Nikolaeva, Eugene V. Radchenko, Evgeny V. Khvatov, Alexey A. Orlov, Vasilisa S. Frolenko, Maksim V. Sukhorukov, Ekaterina S. Kolpakova, Elena Y. Shustova, Anastasiya V. Galochkina, Philipp P. Streshnev, Eugene M. Osipov, Ksenia A. Sapozhnikova, Andrey V. Moiseenko, Vladimir A. Brylev, Gleb V. Proskurin, Yuri S. Dokukin, Sergey V. Kutyakov, Andrey V. Aralov, Vladimir A. Korshun, Sergei V. Strelkov, Vladimir A. Palyulin, Aydar A. Ishmukhametov, Evgeny A. Shirshin, Dmitry I. Osolodkin, Anna A. Shtro, Liubov I. Kozlovskaya, Vera A. Alferova, Alexey V. Ustinov
Publikováno v:
Antiviral Research. 209:105508
Amphipathic nucleoside and non-nucleoside derivatives of pentacyclic aromatic hydrocarbon perylene are known as potent non-cytotoxic broad-spectrum antivirals. Here we report 3-methyl-5-(perylen-3-ylethynyl)-uracil-1-acetic acid and its amides, a new
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb41103ed6709a5665d318635a1b4ac3
https://doi.org/10.1016/j.antiviral.2022.105508
https://doi.org/10.1016/j.antiviral.2022.105508
Autor:
I. V. Mikhura, Gunnar Westman, Vladimir A. Brylev, Brijesh Rathi, Alexey A. Chistov, Ilya O. Aparin, Liubov I. Kozlovskaya, Dmitry I. Osolodkin, Vladimir A. Palyulin, Philipp P. Streshnev, Vladimir A. Korshun, Nikita A. Slesarchuk, Alexey A. Orlov, Alexey V. Ustinov, Sergey V. Kutyakov, Nidhi Jain
Publikováno v:
European Journal of Medicinal Chemistry. 171:93-103
Rigid amphipathic fusion inhibitors (RAFIs) are potent antivirals based on a perylene core linked with a nucleoside moiety. Sugar-free analogues of RAFIs, 5-(perylen-3-ylethynyl)uracil-1-acetic acid 1 and its amides 2, were synthesized using combined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e251c54f299cbdca8f711d7274b79a5
https://doi.org/10.1016/j.ejmech.2019.03.029
https://doi.org/10.1016/j.ejmech.2019.03.029
Autor:
Ksenia A. Sapozhnikova, Dmitry I. Osolodkin, Alexey A. Orlov, Alexey A. Chistov, Vladimir A. Korshun, Vladimir A. Brylev, Nikita A. Slesarchuk, Liubov I. Kozlovskaya, Vladimir A. Palyulin, Eugene V. Radchenko, Alexey V. Ustinov, Evgeny V. Khvatov
Publikováno v:
RSC Advances. 9:26014-26023
The propargylamide of N3-Pom-protected 5-(perylen-3-ylethynyl)uracil acetic acid, a universal precursor, was used in a CuAAC click reaction for the synthesis of several derivatives, including three ramified molecules with high activities against tick
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8afa2bbceeac38c3122eafbecf444fbb
https://doi.org/10.1039/c9ra06313g
https://doi.org/10.1039/c9ra06313g
Autor:
Anastasiya I. Lazarevich, Gleb V. Proskurin, Artjom V. Jegorov, Aydar Ishmukhametov, Alexey A. Chistov, Vadim V. Shmanai, Dmitry I. Osolodkin, Egor A. Ulashchik, Timofei D. Nikitin, Alexey V. Ustinov, Nikita A. Slesarchuk, Liubov I. Kozlovskaya, Andrey V. Aralov, Anton P. Tyurin, Vladimir A. Korshun, Angelina A. Ulanovskaya, Alexey A. Orlov, Evgeny V. Khvatov
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(10)
Rigid amphipathic fusion inhibitors are potent broad-spectrum antivirals based on the perylene scaffold, usually decorated with a hydrophilic group linked via ethynyl or triazole. We have sequentially simplified these structures by removing sugar moi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2c1a65de65d803ce47e3cbf03df6b27
https://pubmed.ncbi.nlm.nih.gov/32199731
https://pubmed.ncbi.nlm.nih.gov/32199731