Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Nikita A. Mitkin"'
Autor:
Nikita A. Mitkin, German E. Kirilkin, Tatiana N. Unguryanu, Sofia Malyutina, Sarah Cook, Alexander V. Kudryavtsev
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Investigating the relationship between alcohol consumption and physical performance, we used data from the 2015–2018 Know Your Heart study on 4215 adults aged 35–69 from Arkhangelsk and Novosibirsk, Russia. We classified participants’
Externí odkaz:
https://doaj.org/article/f48fadd507194516867853ec06fc5001
Autor:
Anton V. Malyshev, Vsevolod V. Pavshintcev, Nikita A. Mitkin, Iuliia A. Sukhanova, Vasilina R. Gedzun, Alexander S. Zlobin, Igor I. Doronin, Gennady A. Babkin, Tomi K. Sawyer
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 18 (2024)
We employed a structural bioinformatics approach to develop novel peptides with predicted affinity to the binding site for negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGluR5). Primary screening in zebrafish (Danio reri
Externí odkaz:
https://doaj.org/article/76cf2f54874a4026980726e84e360222
Autor:
Elina A. Zheremyan, Alina S. Ustiugova, Aksinya N. Uvarova, Nina M. Karamushka, Ekaterina M. Stasevich, Violetta S. Gogoleva, Apollinariya V. Bogolyubova, Nikita A. Mitkin, Dmitry V. Kuprash, Kirill V. Korneev
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Regulatory B lymphocytes (Bregs) are B cells with well-pronounced immunosuppressive properties, allowing them to suppress the activity of effector cells. A broad repertoire of immunosuppressive mechanisms makes Bregs an attractive tool for adoptive c
Externí odkaz:
https://doaj.org/article/99464a452b5944f49b072e4a1c6acb6f
Autor:
Aksinya N. Uvarova, Ekaterina M. Stasevich, Alina S. Ustiugova, Nikita A. Mitkin, Elina A. Zheremyan, Savely A. Sheetikov, Ksenia V. Zornikova, Apollinariya V. Bogolyubova, Mikhail A. Rubtsov, Ivan V. Kulakovskiy, Dmitry V. Kuprash, Kirill V. Korneev, Anton M. Schwartz
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 18, p 13790 (2023)
Single-nucleotide polymorphism rs71327024 located in the human 3p21.31 locus has been associated with an elevated risk of hospitalization upon SARS-CoV-2 infection. The 3p21.31 locus contains several genes encoding chemokine receptors potentially rel
Externí odkaz:
https://doaj.org/article/e24f6e1c27614680b34a6dea7a157abf
Autor:
Alisa M. Gorbacheva, Aksinya N. Uvarova, Alina S. Ustiugova, Arindam Bhattacharyya, Kirill V. Korneev, Dmitry V. Kuprash, Nikita A. Mitkin
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Transforming growth factor beta (TGF-β) is the main cytokine responsible for the induction of the epithelial-mesenchymal transition of breast cancer cells, which is a hallmark of tumor transformation to the metastatic phenotype. Recently, r
Externí odkaz:
https://doaj.org/article/3f04f0958de149dda9d153af34e0a963
Autor:
Anton V. Malyshev, Iuliia A. Sukhanova, Alexander S. Zlobin, Vasilina R. Gedzun, Vsevolod V. Pavshintsev, Ekaterina V. Vasileva, Arthur O. Zalevsky, Igor I. Doronin, Nikita A. Mitkin, Andrey V. Golovin, Maxim L. Lovat, Georgy I. Kovalev, Yurii A. Zolotarev, Askar R. Kuchumov, Gennady A. Babkin, Bernhard Luscher
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
The aim of the study was to develop better anxiolytics and antidepressants. We focused on GABAA receptors and the α2δ auxiliary subunit of V-gated Ca2+ channels as putative targets because they are established as mediators of efficacious anxiolytic
Externí odkaz:
https://doaj.org/article/744533a44c374b5489533f40fc433b89
Autor:
Nikita A. Mitkin, Vsevolod V. Pavshintcev, Iuliia A. Sukhanova, Igor I. Doronin, Gennady A. Babkin, Marianna Sadagurski, Anton V. Malyshev
Publikováno v:
Pharmaceutics, Vol 14, Iss 10, p 2088 (2022)
The aim of this study was to develop a novel peptide potentially applicable for the treatment of metabolic conditions, such as obesity and type 2 diabetes (T2D). We identified CHM-273S from the list of peptides from milk hydrolysate obtained by HPLC/
Externí odkaz:
https://doaj.org/article/ef9a64e452c94d6aac004a5c4486fb75
Autor:
Anton V. Malyshev, Iuliia A. Sukhanova, Valeria M. Ushakova, Yana A. Zorkina, Olga V. Abramova, Anna Y. Morozova, Eugene A. Zubkov, Nikita A. Mitkin, Vsevolod V. Pavshintsev, Igor I. Doronin, Vasilina R. Gedzun, Gennady A. Babkin, Sergio A. Sanchez, Miah D. Baker, Colin N. Haile
Publikováno v:
Pharmaceuticals, Vol 15, Iss 4, p 462 (2022)
We have previously described the LCGA-17 peptide as a novel anxiolytic and antidepressant candidate that acts through the α2δ VGCC (voltage-gated calcium channel) subunit with putative synergism with GABA-A receptors. The current study tested the p
Externí odkaz:
https://doaj.org/article/eba1a1865ee04e8eb42573053d2d6eb5
Autor:
Kirill V. Korneev, Anna N. Kondakova, Ekaterina N. Sviriaeva, Nikita A. Mitkin, Angelo Palmigiano, Andrey A. Kruglov, Georgy B. Telegin, Marina S. Drutskaya, Luisa Sturiale, Domenico Garozzo, Sergei A. Nedospasov, Yuriy A. Knirel, Dmitry V. Kuprash
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)
Toll-like receptor 4 (TLR4) initiates immune response against Gram-negative bacteria upon specific recognition of lipid A moiety of lipopolysaccharide (LPS), the major component of their cell wall. Some natural differences between LPS variants in the
Externí odkaz:
https://doaj.org/article/7e353ae508464947a377f53463282b26
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 12, p 3956 (2018)
Interleukin 33 (IL-33) is a cytokine constitutively expressed by various cells of barrier tissues that contribute to the development of inflammatory immune responses. According to its function as an alarmin secreted by lung and airway epithelium, IL-
Externí odkaz:
https://doaj.org/article/95ef2be3411648a78a91fed840495edc