Zobrazeno 1 - 10
of 158
pro vyhledávání: '"Nikita, Gamper"'
Autor:
Rui Zong, Xiaoding Zhang, Xiaohui Dong, Guan Liu, Jieyao Zhang, Yiting Gao, Zhongyang Zhang, Yiming Ma, Haixia Gao, Nikita Gamper
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
Zinc transporter 3 (ZnT3) is abundantly expressed in the brain, residing in synaptic vesicles, where it plays important roles in controlling the luminal zinc levels. In this study, we found that ZnT3 knockout in mice decreased zinc levels in the hipp
Externí odkaz:
https://doaj.org/article/cd04e46b41054e3bb87672ba394da8af
Autor:
Miriam E. Hurley, Shihab S. Shah, Thomas M. D. Sheard, Hannah M. Kirton, Derek S. Steele, Nikita Gamper, Izzy Jayasinghe
Publikováno v:
Cells, Vol 13, Iss 1, p 38 (2023)
Coordinated events of calcium (Ca2+) released from the endoplasmic reticulum (ER) are key second messengers in excitable cells. In pain-sensing dorsal root ganglion (DRG) neurons, these events can be observed as Ca2+ sparks, produced by a combination
Externí odkaz:
https://doaj.org/article/ed1be321deb1400ab073fea9567ebdb9
Autor:
Eider Nuñez, Frederick Jones, Arantza Muguruza-Montero, Janire Urrutia, Alejandra Aguado, Covadonga Malo, Ganeko Bernardo-Seisdedos, Carmen Domene, Oscar Millet, Nikita Gamper, Alvaro Villarroel
Publikováno v:
eLife, Vol 12 (2023)
Neuronal KV7 channels, important regulators of cell excitability, are among the most sensitive proteins to reactive oxygen species. The S2S3 linker of the voltage sensor was reported as a site-mediating redox modulation of the channels. Recent struct
Externí odkaz:
https://doaj.org/article/0bd7d7f107f1445e8d187383cd53a107
Autor:
Han Hao, Rosmaliza Ramli, Caixue Wang, Chao Liu, Shihab Shah, Pierce Mullen, Varinder Lall, Frederick Jones, Jicheng Shao, Hailin Zhang, David B Jaffe, Nikita Gamper, Xiaona Du
Publikováno v:
PLoS Biology, Vol 21, Iss 1, p e3001958 (2023)
Accumulating observations suggest that peripheral somatosensory ganglia may regulate nociceptive transmission, yet direct evidence is sparse. Here, in experiments on rats and mice, we show that the peripheral afferent nociceptive information undergoe
Externí odkaz:
https://doaj.org/article/c537901d0434420a87a4bcff108dbe55
Autor:
Haiwei Zhang, Hongchen Li, Mingshun Lu, Shengnan Wang, Xueya Ma, Fei Wang, Jiaxi Liu, Xinyu Li, Haichao Yang, Fan Zhang, Haitao Shen, Noel J Buckley, Nikita Gamper, Ebenezer N Yamoah, Ping Lv
Publikováno v:
eLife, Vol 11 (2022)
Repressor element 1-silencing transcription factor (REST) is a transcriptional repressor that recognizes neuron-restrictive silencer elements in the mammalian genomes in a tissue- and cell-specific manner. The identity of REST target genes and molecu
Externí odkaz:
https://doaj.org/article/210f4196a7c74ead814971fb88884f77
Autor:
Yongxue Zhang, Qi Miao, Sai Shi, Han Hao, Xinmeng Li, Zeyao Pu, Yakun Yang, Hailong An, Wei Zhang, Youzhen Kong, Xu Pang, Cunyang Gu, Nikita Gamper, Yi Wu, Hailin Zhang, Xiaona Du
Publikováno v:
Cell Reports, Vol 39, Iss 1, Pp 110625- (2022)
Summary: Protein disulfide isomerase (PDI) plays a key role in maintaining cellular homeostasis by mediating protein folding via catalyzing disulfide bond formation, breakage, and rearrangement in the endoplasmic reticulum. Increasing evidence sugges
Externí odkaz:
https://doaj.org/article/a474577a064a425d89b9b341b2ff4d46
Autor:
Ludi Zhang, Jing Wang, Chenxu Niu, Yu Zhang, Tiantian Zhu, Dongyang Huang, Jing Ma, Hui Sun, Nikita Gamper, Xiaona Du, Hailin Zhang
Publikováno v:
Cell Reports, Vol 37, Iss 5, Pp 109936- (2021)
Summary: Depression symptoms are often found in patients suffering from chronic pain, a phenomenon that is yet to be understood mechanistically. Here, we systematically investigate the cellular mechanisms and circuits underlying the chronic-pain-indu
Externí odkaz:
https://doaj.org/article/3273da8010dd4b809206e648b6f33a46
Autor:
Caixue Wang, Han Hao, Kaitong He, Yating An, Zeyao Pu, Nikita Gamper, Hailin Zhang, Xiaona Du
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
GABA is a major inhibitory neurotransmitter in the mammalian central nervous system (CNS). Inhibitory GABAA channel circuits in the dorsal spinal cord are the gatekeepers of the nociceptive input from the periphery to the CNS. Weakening of these spin
Externí odkaz:
https://doaj.org/article/6616cc7a84fa467f8ebe0c9ac012381f
Autor:
Jonathan Berrout, Eleni Kyriakopoulou, Lavanya Moparthi, Alexandra S. Hogea, Liza Berrout, Cristina Ivan, Mihaela Lorger, John Boyle, Chris Peers, Stephen Muench, Jacobo Elies Gomez, Xin Hu, Carolyn Hurst, Thomas Hall, Sujanitha Umamaheswaran, Laura Wesley, Mihai Gagea, Michael Shires, Iain Manfield, Margaret A. Knowles, Simon Davies, Klaus Suhling, Yurema Teijeiro Gonzalez, Neil Carragher, Kenneth Macleod, N. Joan Abbott, George A. Calin, Nikita Gamper, Peter M. Zygmunt, Zahra Timsah
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
TRPA1 has been reported to contribute lung cancer adenocarcinoma (LUAD), but the mechanisms are unclear. Here the authors propose that TRPA1/FGFR2 interaction is functional in LUAD and show that astrocytes oppose brain metastasis by mediating the dow
Externí odkaz:
https://doaj.org/article/33513ba93d3143cf9c9bd5f381eb5965
Autor:
Min Su, Li Li, Jing Wang, Hui Sun, Ludi Zhang, Chen Zhao, Ying Xie, Nikita Gamper, Xiaona Du, Hailin Zhang
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Dopaminergic neurons in the ventral tegmental area (VTA) encode behavioral patterns important in reward and drug addiction as well as in emotional disorders. These functions of dopamine neurons are directly related to the release of dopamine in the t
Externí odkaz:
https://doaj.org/article/674c1bcd84634482bac1952e3c6e64cd