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A multi-looping chromatin signature predicts dysregulated gene expression in neurons with familial Alzheimer's disease mutations.

Autor: Chandrashekar H; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA.; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania., Simandi Z; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA.; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania., Choi H; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA.; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania., Ryu HS; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA.; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania., Waldman AJ; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA.; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania., Nikish A; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA.; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania., Muppidi SS; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA.; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania., Gong W; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA.; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania., Paquet D; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, 81377, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Phillips-Cremins JE; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA.; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Feb 27. Date of Electronic Publication: 2024 Feb 27.