MCM3 is a novel proliferation marker associated with longer survival for patients with tubo-ovarian high-grade serous carcinoma

Autor: Thomas P. Conrads, Gordana C. Popovic, Lilian van-Wagensveld, Ignace Vergote, Ellen L. Barlow, Annalyn Da-Anoy, Stacey J. Winham, Nicola S. Meagher, Catherine J. Kennedy, Michael Jones, Sabine Heublein, Linda E. Kelemen, Neil Lambie, Paul D.P. Pharoah, Peter Sinn, Claus Høgdall, Sanela Bilic, Alexander Hein, Yovanni Casablanca, Aline Talhouk, Christiani Bisinotto, Chiu-Chen Tseng, Matthias Ruebner, Nhu D Le, Estrid Høgdall, Arndt Hartmann, Malcolm C. Pike, Philipp Harter, Nina Neudeck, Sarah Taylor, Juergen Andress, Anna Fischer, Kunle Odunsi, Naoko Sasamoto, Janine M. Joseph, Marina Pavanello, Derek S. Chiu, Eun Young Kang, Ellen L. Goode, Susan L. Neuhausen, Rhonda Farrell, Stefan Kommoss, Esther Elishaev, Jenny Lester, Yu Yu, Carmel Quinn, Betty Leung, Susan J. Ramus, Jesus Garcia-Donas, Colin J.R. Stewart, Penny Coulson, Joshua Millstein, Adelyn Bolithon, Maria Lycke, Chen Wang, Andreas du Bois, Francesmary Modugno, Alexander B. Olawaiye, Celeste Leigh Pearce, Jessica Boros, G. Larry Maxwell, Constantina Mateoiu, Francisco José Candido dos Reis, Diether Lambrechts, Liselore Loverix, Katrina Tang, Siel Olbrecht, John Lewis Etter, Yee Leung, Kirsten B. Moysich, Katherine LaVigne-Mager, Matthias W. Beckmann, Kathryn L. Terry, Felix K. F. Kommoss, Arantzazu Barquin-Garcia, Monica Yagüe-Fernandez, Sergio Ruiz-Llorente, Helen Steed, M Grube, Michael S Anglesio, Nikilyn Nevins, Sebastian M. Armasu, Mona El-Bahrawy, Beyhan Ataseven, Minouk J. Schoemaker, Annette Staebler, Peter A. Fasching, Gottfried E. Konecny, Terry K. Morgan, Simon A. Gayther, Anna deFazio, Robert A. Vierkant, Martin Köbel, Ramona Erber, Cheng-Han Lee, Paul R. Harnett, Greg Robertson, Linda S Cook, Philip J. Crowe, Daniel W. Cramer, Alison Brand, Yajue Huang, Anusha Hettiaratchi, Florian Heitz, Beth Y. Karlan, Anthony J. Swerdlow, Adeline Tan, Anna H. Wu, Akira Hirasawa, Kate Lawrenson, Karin Sundfeldt, Paul A. Cohen, Robert P. Edwards, Hugo M. Horlings

Publikováno v: Virchows Arch
Kang, E Y, Millstein, J, Popovic, G, Meagher, N S, Bolithon, A, Talhouk, A, Chiu, D S, Anglesio, M S, Leung, B, Tang, K, Lambie, N, Pavanello, M, Da-anoy, A, Lambrechts, D, Loverix, L, Olbrecht, S, Bisinotto, C, Garcia-Donas, J, Ruiz-Llorente, S, Yagüe-Fernandez, M, Edwards, R P, Elishaev, E, Olawaiye, A, Taylor, S, Ataseven, B, du Bois, A, Harter, P, Lester, J, Høgdall, C K, Armasu, S M, Huang, Y, Vierkant, R A, Wang, C, Winham, S J, Heublein, S, Kommoss, F K F, Cramer, D W, Sasamoto, N, van-Wagensveld, L, Lycke, M, Mateoiu, C, Joseph, J, Pike, M C, Odunsi, K, Tseng, C C, Pearce, C L, Bilic, S, Conrads, T P, Hartmann, A, Hein, A, Jones, M E, Leung, Y, Beckmann, M W, Ruebner, M, Schoemaker, M J, Terry, K L, El-Bahrawy, M A, Coulson, P, Etter, J L, LaVigne-Mager, K, Andress, J, Grube, M, Fischer, A, Neudeck, N, Robertson, G, Farrell, R, Barlow, E, Quinn, C, Hettiaratchi, A, Casablanca, Y, Erber, R, Stewart, C J R, Tan, A, Yu, Y, Boros, J, Brand, A H, Harnett, P R, Kennedy, C J, Nevins, N, Morgan, T, Fasching, P A, Vergote, I, Swerdlow, A J, Candido dos Reis, F J, Maxwell, G L, Neuhausen, S L, Barquin-Garcia, A, Modugno, F, Moysich, K B, Crowe, P J, Hirasawa, A, Heitz, F, Karlan, B Y, Goode, E L, Sinn, P, Horlings, H M, Høgdall, E, Sundfeldt, K, Kommoss, S, Staebler, A, Wu, A H, Cohen, P A, DeFazio, A, Lee, C H, Steed, H, Le, N D, Gayther, S A, Lawrenson, K, Pharoah, P D P, Konecny, G, Cook, L S, Ramus, S J, Kelemen, L E & Köbel, M 2022, ' MCM3 is a novel proliferation marker associated with longer survival for patients with tubo-ovarian high-grade serous carcinoma ', Virchows Archiv, vol. 480, pp. 855–871 . https://doi.org/10.1007/s00428-021-03232-0

Tubo-ovarian high-grade serous carcinomas (HGSC) are highly proliferative neoplasms that generally respond well to platinum/taxane chemotherapy. We recently identified minichromosome maintenance complex component 3 (MCM3), which is involved in the in

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https://pubmed.ncbi.nlm.nih.gov/34782936