Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Niki Rana"'
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:4019-4023
In the search for more potent peptide-based anti-cancer conjugates the generation of new, functionally diverse nucleolipid derived D-(KLAKLAK)2-AK sequences has enabled a structure and anti-cancer activity relationship study. A reductive amination ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::296fdd1a069d26ab3fc31cbfa92c72f3
https://doi.org/10.1016/j.bmcl.2017.07.056
https://doi.org/10.1016/j.bmcl.2017.07.056
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(15)
The synthesis, characterization and anti-cancer activity of a novel peptide nucleolipid bioconjugate is reported in this study. The prerequisite 5′-carboxy derived nucleolipid was synthesized following a five-step solution-phase approach and then c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edff3e33a2b5b10b4abb2a732e85fbe5
https://pubmed.ncbi.nlm.nih.gov/27329798
https://pubmed.ncbi.nlm.nih.gov/27329798
Publikováno v:
ChemInform. 47
Nucleoside- and nucleotide-based chemotherapeutics have been used to treat cancer for more than 50 years. However, their inherent cytotoxicities and the emergent resistance of tumors against treatment has inspired a new wave of compounds in which the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5438ade45d288e8ef4ea4e971833b5d
https://doi.org/10.1002/chin.201612284
https://doi.org/10.1002/chin.201612284
Publikováno v:
ChemMedChem. 11(3)
Nucleoside- and nucleotide-based chemotherapeutics have been used to treat cancer for more than 50 years. However, their inherent cytotoxicities and the emergent resistance of tumors against treatment has inspired a new wave of compounds in which the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25f9cd19f5013403b782dec788f3bc5c
https://pubmed.ncbi.nlm.nih.gov/26663095
https://pubmed.ncbi.nlm.nih.gov/26663095
Autor:
David Sabatino, Niki Rana
Publikováno v:
Peptides 2015, Proceedings of the 24th American Peptide Symposium.
The apoptosis inducing (pro-apoptotic) peptide sequence, D-(KLAKLAK)2, has been classified as a potent antimicrobial agent [1]. Moreover, it was found to trigger cell death in bacteria without inducing cytotoxicity in mammalian cell types. The chemic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc899b7f19826b6d72e12b1859e192f9
https://doi.org/10.17952/24aps.2015.191
https://doi.org/10.17952/24aps.2015.191