Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Niki R. Patel"'
Autor:
Niki R. Patel, Danielle Schultz
Publikováno v:
The Power of High-Throughput Experimentation: Case Studies from Drug Discovery, Drug Development, and Catalyst Discovery (Volume 2) ISBN: 9780841297555
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::486fd700ed03c84bd9f5226286538668
https://doi.org/10.1021/bk-2022-1420.ch007
https://doi.org/10.1021/bk-2022-1420.ch007
Autor:
Aaron M. Whittaker, Serge Ruccolo, Artis Klapars, Sandra A. Robaire, Neil A. Strotman, Mark A. Huffman, Anna Fryszkowska, Shaoguang Zhang, Heather C. Johnson, Niki R. Patel
Publikováno v:
Organic & Biomolecular Chemistry. 19:1620-1625
Galactose oxidase (GOase) is a Cu-dependent metalloenzyme that catalyzes the oxidation of alcohols to aldehydes. An evolved GOase variant was recently shown to catalyze a desymmetrizing oxidation as the first enzymatic step in the biocatalytic synthe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3099c48ad086f001172000733ddf6f07
https://doi.org/10.1039/d0ob02395g
https://doi.org/10.1039/d0ob02395g
Autor:
Marko Nesic, David B. Ryffel, Jonathan Maturano, Michael Shevlin, Scott R. Pollack, Donald R. Gauthier, Pablo Trigo-Mouriño, Li-Kang Zhang, Danielle M. Schultz, Jamie M. McCabe Dunn, Louis-Charles Campeau, Niki R. Patel, David A. Petrone, David Sarlah
The total synthesis of darobactin A, a recently isolated antibiotic that selectively targets Gram-negative bacteria, has been accomplished in a convergent fashion with a longest linear sequence of 16 steps from ᴅ-Garner’s aldehyde and ʟ-serine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85995d27bf0e6c17b4961bc72d2ca3c0
https://doi.org/10.26434/chemrxiv-2022-c4mz6
https://doi.org/10.26434/chemrxiv-2022-c4mz6
Autor:
Xiao Wang, Justin A. Newman, Aaron M. Whittaker, Heather C. Johnson, Teresa Andreani, Kevin M. Maloney, Niki R. Patel, Mark A. Huffman, Mark McLaughlin, Bangwei Ding
Publikováno v:
Chemistry – A European Journal. 26:14118-14123
A 5-step enantioselective synthesis of the potent anti-HIV nucleoside islatravir is reported. The highly efficient route was enabled by a novel enantioselective alkynylation of an α,β-unsaturated ketone, a unique ozonolysis-dealkylation cascade in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3ad69882d0d18454dffc9164ce24b67
https://doi.org/10.1002/chem.202003091
https://doi.org/10.1002/chem.202003091
Autor:
Edward C. Sherer, Junyong Jo, Holst M. Halsey, Jack Liang, Niki R. Patel, Agustina Rodriguez-Granillo, Christopher C. Nawrat, Aaron M. Whittaker, Canada Keith A, Margie Borra-Garske, Nicholas M. Marshall, Kevin R. Campos, Anna Fryszkowska, Yingju Xu, Paul N. Devine, Shane T. Grosser, Grant S. Murphy, Jovana Nazor, Matthew D. Truppo, Benjamin F. Mann, Jeffrey C. Moore, Sandra A. Robaire, Gregory Hughes, Scott J. Novick, Da Duan, Jacob Forstater, Joshua N. Kolev, Deeptak Verma, Kevin M. Maloney, Oscar Alvizo, Mark A. Huffman, Li Xiao, Mark McLaughlin, Leo A. Joyce, Hao Yang
Publikováno v:
Science. 366:1255-1259
Maximal efficiency from enzyme cascades Enzymes are highly selective catalysts that can be useful for specific transformations in organic synthesis. Huffman et al. combined designer enzymes in a multistep cascade reaction (see the Perspective by O'Re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6857e349911e642ce3747f4ecbdaad7
https://doi.org/10.1126/science.aay8484
https://doi.org/10.1126/science.aay8484
Autor:
Tan L, Li D, Wan B, Niki R. Patel, Eric B. Sirota, Xu F, Varsolona Rj, Qi J, Wyvratt Bm, Song Zj, Kuethe Jt, Muzzio Dj, Qiao Z, Chen Y, Yingju Xu, Shang G, Dropinski Jf, Zhang S, Gregory Hughes, Mathew R, Zhao R, Justin A. Newman, Christopher C. Nawrat, Ouyang H, Rummelt Sm, Yin J, Margelefsky E, Kevin M. Maloney
The unnatural, alkyne-containing nucleoside analog islatravir (MK-8591) is synthetically accessed through a biocatalytic cascade starting from 2-ethynylglycerol as a building block. Herein, we describe the development of an efficient synthesis of thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::037c4648fcf2256380c2d6d77e9b03d4
https://doi.org/10.26434/chemrxiv.14502744
https://doi.org/10.26434/chemrxiv.14502744
Autor:
Mark A. Huffman, Yingju Xu, Aaron M. Whittaker, Kevin M. Maloney, Teresa Andreani, David M. Tschaen, Andrew Brunskill, François Lévesque, Hongming Li, Christopher C. Nawrat, Mark McLaughlin, Hao Yang, Anna Fryszkowska, Niki R. Patel
Publikováno v:
Organic letters. 22(12)
The synthesis of the potent anti-HIV investigational treatment islatravir is described. The key step in this synthesis is a highly enantioselective catalytic asymmetric alkynylation of a ketone. This reaction is a rare example of the asymmetric addit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8866cb9f28b97cbbb694b890f24515f1
https://pubmed.ncbi.nlm.nih.gov/32516536
https://pubmed.ncbi.nlm.nih.gov/32516536
Autor:
Marion H. Emmert, Matthieu Jouffroy, David C. Leitch, Alexander Buitrago Santanilla, Gemma Cook, Amanda Dombrowski, Nathan Gesmundo, Dipannita Kalyani, Mycah Uehling, Michael Wleklinski, Nicole C. Goodwin, Katherine Honicker, Jonathan Latham, Katherine M. P. Wheelhouse, Sabine Fenner, Matthew P. Whiting, Chunrui Sun, Ji Qi, Feng Peng, Niki R. Patel, Danielle Schultz, Orion Staples, Jacob S. Mohar, Daniel J. Mindiola, Victoria Dimakos, Stephen G. Newman, Stig D. Friis, Erik Weis, Magnus J. Johansson
'High-throughput experimentation (HTE) is an emerging and powerful approach to problems in organic chemistry and homogeneous catalysis. This book is targeted at both experts and those new to the field who are seeking general perspectives and design p
Publikováno v:
ACS Catalysis. 7:6065-6069
A protocol for the aminomethylation of aryl halides using α-silylamines via Ni/photoredox dual catalysis is described. The low oxidation potential of these silylated species enables facile single electron transfer (SET) oxidation of the amine follow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2980ce4cbbbae84fbf2a3eb669ade5b
https://doi.org/10.1021/acscatal.7b01973
https://doi.org/10.1021/acscatal.7b01973
Publikováno v:
ACS Catalysis
An operationally simple, mild, redox-neutral method for the photoredox alkylation of imines is reported. Utilizing an inexpensive organic photoredox catalyst, alkyl radicals are readily generated from the single-electron oxidation of ammonium alkyl b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42df00df8898ae6f28e6b735cf6a1093
https://doi.org/10.1021/acscatal.6b03665
https://doi.org/10.1021/acscatal.6b03665