Neddylation inhibition sensitises renal medullary carcinoma tumours to platinum chemotherapy.

Autor: Shapiro, Daniel D.^1,2 (AUTHOR), Zacharias, Niki Millward³ (AUTHOR), Tripathi, Durga N.⁴ (AUTHOR), Karki, Menuka⁵ (AUTHOR), Bertocchio, Jean‐Philippe⁵ (AUTHOR), Soeung, Melinda⁵ (AUTHOR), He, Rong⁵ (AUTHOR), Westerman, Mary E.³ (AUTHOR), Gao, Jianjun⁵ (AUTHOR), Rao, Priya⁶ (AUTHOR), Lam, Truong N. A.⁵ (AUTHOR), Jonasch, Eric⁵ (AUTHOR), Perelli, Luigi⁵ (AUTHOR), Cheng, Emily H.⁷ (AUTHOR), Carugo, Alessandro^8,9,10 (AUTHOR), Heffernan, Timothy P.^8,9 (AUTHOR), Walker, Cheryl L.⁴ (AUTHOR), Genovese, Giannicola^5,11,12 (AUTHOR), Tannir, Nizar M.⁵ (AUTHOR), Karam, Jose A.^3,13 (AUTHOR)

Publikováno v: Clinical & Translational Medicine. May2023, Vol. 13 Issue 5, p1-18. 18p.

SMARCB1 regulates the hypoxic stress response in sickle cell trait

Autor: Melinda Soeung, Luigi Perelli, Ziheng Chen, Eleonora Dondossola, I-Lin Ho, Federica Carbone, Li Zhang, Hania Khan, Courtney N. Le, Cihui Zhu, Michael D. Peoples, Ningping Feng, Shan Jiang, Niki Millward Zacharias, Rosalba Minelli, Daniel D. Shapiro, Angela K. Deem, Sisi Gao, Emily H. Cheng, Donatella Lucchetti, Cheryl L. Walker, Alessandro Carugo, Virginia Giuliani, Timothy P. Heffernan, Andrea Viale, Nizar M. Tannir, Giulio F. Draetta, Pavlos Msaouel, Giannicola Genovese

Publikováno v: Proceedings of the National Academy of Sciences. 120

Renal medullary carcinoma (RMC) is an aggressive kidney cancer that almost exclusively develops in individuals with sickle cell trait (SCT) and is always characterized by loss of the tumor suppressor SMARCB1 . Because renal ischemia induced by red bl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::457424d723572530c9eac6b8d04b2643
https://doi.org/10.1073/pnas.2209639120

PD43-01 PEVONEDISTAT SENSITIZES RENAL MEDULLARY CARCINOMA CELLS TO CARBOPLATIN BY DISRUPTING DNA DAMAGE REPAIR MECHANISMS

Autor: Daniel Shapiro, Niki Millward Zacharias, Durga Tripathi, Jean-Philippe Bertocchio, Melinda Soeung, Rong He, Jianjun Gao, Priya Rao, Truong Lam, Luigi Perelli, Alessandro Carugo, Timothy Heffernan, Cheryl Walker, Giannicola Genovese, Nizar Tannir, Christopher Wood, Jose Karam, Pavlos Msaouel

Publikováno v: Journal of Urology. 207

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::612178fae19f61c2ffe5f6854ef937cf
https://doi.org/10.1097/ju.0000000000002604.01

Abstract 1247: Targeting neddylation in combination with cytotoxic chemotherapy for the treatment of renal medullary carcinoma

Autor: Nizar M. Tannir, Cheryl L. Walker, Durga Nand Tripathi, Priya Rao, Jose A. Karam, Christopher G. Wood, Giannicola Genovese, Niki Millward Zacharias, Melinda Soeung, Jean-Philippe Bertocchio, Pavlos Msaouel, Daniel D. Shapiro

Publikováno v: Cancer Research. 81:1247-1247

Renal medullary carcinoma (RMC) is a rare and highly aggressive malignancy that affects primarily young patients of African descent with sickle cell trait. No targeted therapies are currently approved for patients with RMC and the median survival fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::41207433e0f8ae09efa32878d8ff46e3
https://doi.org/10.1158/1538-7445.am2021-1247

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