Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Nikhil T, Awatade"'
Autor:
Nikhil T. Awatade, Andrew T. Reid, Kristy S. Nichol, Kurtis F. Budden, Punnam Chander Veerati, Prabuddha S. Pathinayake, Christopher L. Grainge, Philip M. Hansbro, Peter A. B. Wark
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Primary air liquid interface (ALI) cultures of bronchial epithelial cells are used extensively to model airway responses. A recent advance is the development of conditional reprogramming that enhances proliferative capability. Several differ
Externí odkaz:
https://doaj.org/article/34e398b88c08484c9891f298e967ba74
Autor:
Sharon L. Wong, Nikhil T. Awatade, Miro A. Astore, Katelin M. Allan, Michael J. Carnell, Iveta Slapetova, Po-chia Chen, Alexander Capraro, Laura K. Fawcett, Renee M. Whan, Renate Griffith, Chee Y. Ooi, Serdar Kuyucak, Adam Jaffe, Shafagh A. Waters
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103710- (2022)
Summary: Characterization of I37R, a mutation located in the lasso motif of the CFTR chloride channel, was conducted by theratyping several CFTR modulators from both potentiator and corrector classes. Intestinal current measurements in rectal biopsie
Externí odkaz:
https://doaj.org/article/9a4dc92c469442f8afda25d75b18cedf
Publikováno v:
Viruses, Vol 15, Iss 2, p 402 (2023)
Type 2 immune responses are characterized by elevated type 2 cytokines and blood eosinophilia. Emerging evidence suggests that people with chronic type 2 inflammatory lung diseases are not particularly susceptible to SARS-CoV-2 infection. Intriguingl
Externí odkaz:
https://doaj.org/article/c06bd17fd4ba4d5a891e863f7f5ee603
Autor:
Nikhil T. Awatade, Sharon L. Wong, Chris K. Hewson, Laura K. Fawcett, Anthony Kicic, Adam Jaffe, Shafagh A. Waters
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Cystic fibrosis (CF) is an inherited disorder where individual disease etiology and response to therapeutic intervention is impacted by CF transmembrane regulator (CFTR) mutations and other genetic modifiers. CFTR regulates multiple mechanisms in a d
Externí odkaz:
https://doaj.org/article/bcde30b6e3df42a8aed082c28468ded6
Autor:
Nikhil T Awatade, Andrew T Reid, Kristy S Nichol, Kurtis F Budden, Punnam Chander Veerati, Prabuddha S Pathinayake, Christopher L Grainge, Philip M Hansbro, Peter AB Wark
Introduction: Primary air liquid interface (ALI) cultures of bronchial epithelial cells are used extensively to model airway responses. A recent advance is the development of conditional reprogramming that enhances proliferative capability. Several d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::192d26bfb5f6cbca80f86e499d61003c
https://doi.org/10.21203/rs.3.rs-2914728/v1
https://doi.org/10.21203/rs.3.rs-2914728/v1
Autor:
Nikhil T Awatade, Andrew T Reid, Kristy S Nichol, Kurtis F Budden, Punnam C Veerati, Prabuddha S Pathinayake, Christopher L Grainge, Philip M Hansbro, Peter AB Wark
IntroductionPrimary air liquid interface (ALI) cultures of bronchial epithelial cells are used extensively to model airway responses. A recent advance is the development of conditional reprogramming that enhances proliferative capability. Several dif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad66fa350b679068a53b5cddb2ba7b17
https://doi.org/10.1101/2023.04.12.536514
https://doi.org/10.1101/2023.04.12.536514
Autor:
Chris K. Hewson, Alexander Capraro, Sharon L. Wong, Elvis Pandzic, Ling Zhong, Bentotage S. M. Fernando, Nikhil T. Awatade, Gene Hart-Smith, Renee M. Whan, Shane R. Thomas, Adam Jaffe, Wallace J. Bridge, Shafagh A. Waters
Publikováno v:
Antioxidants, Vol 9, Iss 12, p 1204 (2020)
Systemic glutathione deficiency, inflammation, and oxidative stress are hallmarks of cystic fibrosis (CF), an inherited disease that causes persistent lung infections and severe damage to the respiratory system and many of the body organs. Improvemen
Externí odkaz:
https://doaj.org/article/ded626cf578c43c38dbe8569a71c6601
Autor:
Nikhil T. Awatade, Inna Uliyakina, Carlos M. Farinha, Luka A. Clarke, Karina Mendes, Amparo Solé, Juan Pastor, Maria Margarida Ramos, Margarida D. Amaral
Publikováno v:
EBioMedicine, Vol 2, Iss 2, Pp 147-153 (2015)
Background: The best investigational drug to treat cystic fibrosis (CF) patients with the most common CF-causing mutation (F508del) is VX-809 (lumacaftor) which recently succeeded in Phase III clinical trial in combination with ivacaftor. This correc
Externí odkaz:
https://doaj.org/article/c8f45f3ca0f24029b2da7b6c15d75a5c
Autor:
Elvis Pandzic, Nihan Turgutoglu, Iveta Slapetova, Renee Whan, Sharon L. Wong, Ling Zhong, Shafagh A. Waters, Adam Jaffe, Nikhil T. Awatade, Laura K. Fawcett, Alexander Capraro
Publikováno v:
Journal of Cystic Fibrosis. 20:364-371
Background Patient-derived airway cells differentiated at Air Liquid Interface (ALI) are valuable models for Cystic fibrosis (CF) precision therapy. Different culture expansion methods have been established to extend expansion capacity of airway basa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e3619070ea2b7a4823805f76ca6bae7
https://doi.org/10.1016/j.jcf.2020.12.019
https://doi.org/10.1016/j.jcf.2020.12.019
Autor:
Marne C. Hagemeijer, Nikhil T. Awatade, Christian Tischer, Annelotte M. Vonk, Margarida D. Amaral, Jeffrey M. Beekman, Volker Hilsenstein, Iris A.L. Silva, Hugo M. Botelho
Publikováno v:
Bioinformatics. 36:5686-5694
MotivationThe forskolin-induced swelling (FIS) assay has become the preferential assay to predict the efficacy of approved and investigational CFTR-modulating drugs for individuals with cystic fibrosis (CF). Currently, no standardized quantification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66623b3bdb3114a99e8021659d978906
https://doi.org/10.1093/bioinformatics/btaa1073
https://doi.org/10.1093/bioinformatics/btaa1073