An observer-blinded, cluster randomised trial of a typhoid conjugate vaccine in an urban South Indian cohort

Autor: Nikhil Sahai, Dilesh Kumar Arunachalam, Tim Morris, Andrew Copas, Prasanna Samuel, Venkata Raghava Mohan, Vinod Abraham, Joshua Anish Selwyn, Praveen Kumar, Winsley Rose, Veeraraghavan Balaji, Gagandeep Kang, Jacob John

Publikováno v: Trials, Vol 24, Iss 1, Pp 1-10 (2023)

Abstract Background Typhoid fever causes nearly 110,000 deaths among 9.24 million cases globally and disproportionately affects developing countries. As a control measure in such regions, typhoid conjugate vaccines (TCVs) are recommended by the World

Externí odkaz: https://doaj.org/article/37b6dceb9cf949a6a18dabb61cba903e

Disordered autonomic function during exposure to moderate heat or exercise in a mouse model of Dravet syndrome

Autor: Nikhil Sahai, Angela M. Bard, Orrin Devinsky, Franck Kalume

Publikováno v: Neurobiology of Disease, Vol 147, Iss , Pp 105154- (2021)

Objective: To examine autonomic regulation of core body temperature, heart rate (HR), and breathing rate (BR) in response to moderately elevated ambient temperature or moderate physical exercise in a mouse model of Dravet syndrome (DS). Methods: We s

Externí odkaz: https://doaj.org/article/55a47f0a31354d2ab1e5b8c028e9f025

Human

Autor: Aguan D, Wei, Paul, Wakenight, Theresa A, Zwingman, Angela M, Bard, Nikhil, Sahai, Marjolein H, Willemsen, Helenius J, Schelhaas, Alexander P A, Stegmann, Judith S, Verhoeven, Stella A, de Man, Marja W, Wessels, Tjitske, Kleefstra, Deepali N, Shinde, Katherine L, Helbig, Alice, Basinger, Victoria F, Wagner, David, Rodriguez-Buritica, Emily, Bryant, John J, Millichap, Kathleen J, Millen, William B, Dobyns, Jan-Marino, Ramirez, Franck K, Kalume

Publikováno v: J Neurophysiol

We identified six novel de novo human KCNQ5 variants in children with motor/language delay, intellectual disability (ID), and/or epilepsy by whole exome sequencing. These variants, comprising two nonsense and four missense alterations, were functiona

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7bb22d128da88c1a4a5199219f0c020e
https://pubmed.ncbi.nlm.nih.gov/35583973

Human KCNQ5 de novo Mutations Underlie Epilepsy and Intellectual Disability

Autor: Aguan D. Wei, Paul Wakenight, Theresa A. Zwingman, Angela M. Bard, Nikhil Sahai, Marjolein H. Willemsen, Helenius J. Schelhaas, Alexander P. A. Stegmann, Judith S. Verhoeven, Stella A. de Man, Marja W. Wessels, Tjitske Kleefstra, Deepali N. Shinde, Katherine L. Helbig, Alice Basinger, Victoria F. Wagner, David Rodriguez-Buritica, Emily Bryant, John J. Millichap, Kathleen J. Millen, William B. Dobyns, Jan-Marino Ramirez, Franck K. Kalume

Publikováno v: Journal of Neurophysiology, 128(1), 40-61. American Physiological Society
Journal of Neurophysiology, 128, 40-61
Journal of Neurophysiology, 128, 1, pp. 40-61

We identified six novel de novo human KCNQ5 variants in children with motor/language delay, intellectual disability (ID), and/or epilepsy by whole exome sequencing. These variants, comprising two nonsense and four missense alterations, were functiona

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::642861c243e1b13561f237e928630bf1
https://doi.org/10.1152/jn.00509.2021

Two-Attending Surgeon Teams Improve Outcomes of Single-Level Anterior Cervical Discectomy and Fusion

Autor: Stuart Changoor, Michael Faloon, Conor J. Dunn, Nikhil Sahai, Daniel Coban, Stephen Saela, Kumar Sinha, Ki Soo Hwang, Arash Emami

Publikováno v: Journal of long-term effects of medical implants. 32(3)

Given the shift toward value-based healthcare, strategies that decrease risk in commonly performed procedures such as anterior cervical discectomy and fusion (ACDF) are of interest. The objective of this study was to analyze the effect of a two-atten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d12354f8da5397b6ea5283a75fdcbbd
https://pubmed.ncbi.nlm.nih.gov/35993983