Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Nikhil S. Sakle"'
Publikováno v:
Heliyon, Vol 10, Iss 14, Pp e34531- (2024)
Background: Prostate cancer (PCa) remains a significant health concern globally, prompting a continual search for novel therapeutic strategies. In this study, we employed a comprehensive approach combining network pharmacology, molecular docking and
Externí odkaz:
https://doaj.org/article/4be4fbae249d45f29372de60ecba5590
Autor:
Jaiprakash N. Sangshetti, Rashmi S. Chouthe, Mohan R. Jadhav, Nikhil S. Sakle, Aniruddha Chabukswar, Indrajeet Gonjari, Sunil Darandale, Devanand B. Shinde
Publikováno v:
Arabian Journal of Chemistry, Vol 10, Iss S1, Pp S1356-S1363 (2017)
A facile, green approach for the synthesis of some new dibenz[1,4]-diazepine-1-one by a three component reaction of Diamine, 1,3 diketone and aromatic aldehyde using oxalic acid as catalyst in water is described. The products are formed in good yield
Externí odkaz:
https://doaj.org/article/677061bcf686451da34115ad26be8348
Publikováno v:
Nutrition and Cancer. 74:2222-2234
In our previous study Alysicarpus vaginalis (AV) has appeared as a promising target for breast cancer hence we have screened potential targets by in silico, In Vitro and In Vivo methods. A network ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95800ca04f288dcb66da260c12d938f9
https://doi.org/10.1080/01635581.2021.1986080
https://doi.org/10.1080/01635581.2021.1986080
Targeting Small Molecule Tyrosine Kinases by Polyphenols: New Move Towards Anti-tumor Drug Discovery
Publikováno v:
Current Drug Discovery Technologies. 17:585-615
Background: Cancer is a complex disease involving genetic and epigenetic alteration that allows cells to escape normal homeostasis. Kinases play a crucial role in signaling pathways that regulate cell functions. Deregulation of kinases leads to a var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::099bf726a55f79ae17386dd8ea10966a
https://doi.org/10.2174/1570163816666190808120843
https://doi.org/10.2174/1570163816666190808120843
Publikováno v:
Nutrition and Cancer. 72:1243-1253
The present study intended to assess the anticancer potential of Alysicarpus vaginalis ethyl acetate fraction (AVEAF) in breast cancer cell lines (MCF-7 and MDA-MB-453) and against N-methyl-N-nitrosourea (MNU) induced mammary carcinoma in Sprague-Daw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::edef474bcea2bb54a38e06bea00ff60c
https://doi.org/10.1080/01635581.2019.1670855
https://doi.org/10.1080/01635581.2019.1670855
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Caesalpinia pulcherima (CP) is a traditional herb used for the treatment of asthma, bronchitis, cancer, anti-bacterial, anti-fungal and as abortifacient. In the present study, bioactive components and potential targets in the treatment of breast canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da8f9a87c1bb6939316cb1c49148795b
http://europepmc.org/articles/PMC7560621
http://europepmc.org/articles/PMC7560621
Publikováno v:
Virology
Novel coronavirus (SARS-CoV-2), turned out to be a global pandemic with unstoppable morbidity and mortality rate. However, till date there is no effective treatment found against SARS-CoV-2. We report on the major in-depth molecular and docking analy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a676f03ff8d5fd860b920bf5f8510c5
https://pubmed.ncbi.nlm.nih.gov/33421743
https://pubmed.ncbi.nlm.nih.gov/33421743
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 18:1009-1015
Methods: A novel series of isoxazole (S21-S30) derivatives were designed, synthesized and screened for their anticancer activity against estrogen receptor-positive MCF-7 and negative MDA-MB-435 breast cancer cell lines. The synthesized derivative has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e379bd78faa144bd103f65240779cb3f
https://doi.org/10.2174/1871520618666171129153655
https://doi.org/10.2174/1871520618666171129153655
Publikováno v:
Biomedicine & Pharmacotherapy. 89:966-972
By utilizing concept of molecular hybridization, involving combination of various Pharmacophore, novel substituted coumarin-chalcone hybrids was synthesized and evaluated for anti-proliferative activity against estrogen receptor-positive MCF-7 and ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd095907a00ac8e2b7048325aeb7f123
https://doi.org/10.1016/j.biopha.2017.02.089
https://doi.org/10.1016/j.biopha.2017.02.089
Autor:
Sunil N. Darandale, Nikhil S. Sakle, Aniruddha R. Chabukswar, Jaiprakash N. Sangshetti, Devanand B. Shinde, Rashmi S. Chouthe, Mohan R. Jadhav, Indrajeet D. Gonjari
Publikováno v:
Arabian Journal of Chemistry, Vol 10, Iss S1, Pp S1356-S1363 (2017)
A facile, green approach for the synthesis of some new dibenz[1,4] - diazepine-1-one by a three component reaction of Diamine, 1,3 diketone and aromatic aldehyde using oxalic acid as catalyst in water is described. The products are formed in good yie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee8a47a6c9a01e15eb3fdaeaa12d8fff
https://doi.org/10.1016/j.arabjc.2013.04.004
https://doi.org/10.1016/j.arabjc.2013.04.004