Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Nikhil S. Rao"'
Autor:
Suraj S. Vasanthi, Nikhil S. Rao, Manikandan Samidurai, Nyzil Massey, Christina Meyer, Meghan Gage, Mihir Kharate, Aida Almanza, Logan Wachter, Candide Mafuta, Lily Trevino, Adriana M. Carlo, Elijah Bryant, Brooke E. Corson, Morgan Wohlgemuth, Morgan Ostrander, Lucas Showman, Chong Wang, Thimmasettappa Thippeswamy
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-25 (2023)
Abstract Background Acute exposure to seizurogenic organophosphate (OP) nerve agents (OPNA) such as diisopropylfluorophosphate (DFP) or soman (GD), at high concentrations, induce immediate status epilepticus (SE), reactive gliosis, neurodegeneration,
Externí odkaz:
https://doaj.org/article/27b5448e94704f1a86180ed9deaf58b0
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Neurodegeneration and neuroinflammation are key processes of epileptogenesis in temporal lobe epilepsy (TLE). A considerable number (∼30%) of patients with epilepsy are resistant to currently available antiseizure drugs and thus there is a need to
Externí odkaz:
https://doaj.org/article/80bd9bddf2c642c8ae1500f79d473c8a
Autor:
Christina Meyer, Nikhil S. Rao, Suraj S. Vasanthi, Beatriz Pereira, Meghan Gage, Marson Putra, Claire Holtkamp, Joselyn Huss, Thimmasettappa Thippeswamy
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Organophosphates (OP) are highly toxic chemical nerve agents that have been used in chemical warfare. Currently, there are no effective medical countermeasures (MCMs) that mitigate the chronic effects of OP exposure. Oxidative stress is a key mechani
Externí odkaz:
https://doaj.org/article/ee60e460bdda414980be652438df1986
Autor:
Christina Meyer, Elizabeth Grego, Suraj S. Vasanthi, Nikhil S. Rao, Nyzil Massey, Claire Holtkamp, Joselyn Huss, Lucas Showman, Balaji Narasimhan, Thimmasettappa Thippeswamy
Publikováno v:
Antioxidants, Vol 12, Iss 12, p 2061 (2023)
NADPH oxidase (NOX) is a primary mediator of superoxides, which promote oxidative stress, neurodegeneration, and neuroinflammation after diisopropylfluorophosphate (DFP) intoxication. Although orally administered mitoapocynin (MPO, 10 mg/kg), a mitoc
Externí odkaz:
https://doaj.org/article/331dd32870e5452ba3ebce96b8785c24
Autor:
Nikhil S. Rao, Christina Meyer, Suraj S. Vasanthi, Nyzil Massey, Manikandan Samidurai, Meghan Gage, Marson Putra, Aida N. Almanza, Logan Wachter, Thimmasettappa Thippeswamy
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Sex is a biological variable in experimental models. In our previous diisopropylfluorophosphate (DFP) studies, female rats required a higher dose of DFP to achieve a somewhat similar severity of status epilepticus (SE) as males. In those studies, mal
Externí odkaz:
https://doaj.org/article/3365a7c48d5447a38cc68c990cfcd13b
Autor:
Meghan Gage, Nikhil S. Rao, Manikandan Samidurai, Marson Putra, Suraj S. Vasanthi, Christina Meyer, Chong Wang, Thimmasettappa Thippeswamy
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2022)
Modeling a real-world scenario of organophosphate nerve agent (OPNA) exposure is challenging. Military personnel are premedicated with pyridostigmine, which led to the development of OPNA models with pyridostigmine/oxime pretreatment to investigate n
Externí odkaz:
https://doaj.org/article/631974d04d3d4aefa5b682931e544a3c
Autor:
Meghan Gage, Suraj S Vasanthi, Christina M Meyer, Nikhil S Rao, Daniel R Thedens, Sridhar S. Kannurpatti, Thimmasettappa Thippeswamy
Publikováno v:
Epilepsia Open.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4596b1b507bbf216bd5019b0a3fc1cb0
https://doi.org/10.1002/epi4.12701
https://doi.org/10.1002/epi4.12701
Autor:
Meghan, Gage, Nikhil S, Rao, Manikandan, Samidurai, Marson, Putra, Suraj S, Vasanthi, Christina, Meyer, Chong, Wang, Thimmasettappa, Thippeswamy
Publikováno v:
Frontiers in cellular neuroscience. 15
Modeling a real-world scenario of organophosphate nerve agent (OPNA) exposure is challenging. Military personnel are premedicated with pyridostigmine, which led to the development of OPNA models with pyridostigmine/oxime pretreatment to investigate n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::78294bff3830cfdfe3587a0ddbe8fe3c
https://pubmed.ncbi.nlm.nih.gov/35197823
https://pubmed.ncbi.nlm.nih.gov/35197823
Autor:
Meghan Gage, Suraj S Vasanthi, Christina M Meyer, Nikhil S Rao, Daniel R Thedens, Sridhar S. Kannurpatti, Thimmasettappa Thippeswamy
Publikováno v:
Epilepsia Open, Vol 8, Iss 2, Pp 399-410 (2023)
Abstract Objective Exposure to the nerve agent, soman (GD), induces status epilepticus (SE), epileptogenesis, and even death. Although rodent models studying the pathophysiological mechanisms show females to be more reactive to soman, no tangible sex
Externí odkaz:
https://doaj.org/article/5cf3a7149c2048d9ab198687bb4291b4