Zobrazeno 1 - 10 of 68 pro vyhledávání: '"Nikhil S, Joshi"'
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Akademický článek
ScRNA-seq defines dynamic T-cell subsets in longitudinal colon and peripheral blood samples in immune checkpoint inhibitor-induced colitis
Autor: Clara Abraham, Marie E Robert, Harriet M Kluger, Lilach Aizenbud, Kevan C Herold, Matthew R Austin, Jacqueline E Mann, Ross D Merkin, Liliana Lucca, Badr Al Bawardy, Khadir Raddassi, Nikhil S Joshi, David A Hafler
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss 8 (2023)
Immune checkpoint inhibitors (ICIs) are increasingly being used to manage multiple tumor types. Unfortunately, immune-related adverse events affect up to 60% of recipients, often leading to treatment discontinuation in settings where few alternative
Externí odkaz: https://doaj.org/article/9756494ca35a45cda13db78f98f7441b
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2
Clonal lineage tracing reveals mechanisms skewing CD8+ T cell fate decisions in chronic infection
Autor: Moujtaba Y. Kasmani, Ryan Zander, H. Kay Chung, Yao Chen, Achia Khatun, Martina Damo, Paytsar Topchyan, Kaitlin E. Johnson, Darya Levashova, Robert Burns, Ulrike M. Lorenz, Vera L. Tarakanova, Nikhil S. Joshi, Susan M. Kaech, Weiguo Cui
Publikováno v: The Journal of experimental medicine. 220(1)
Although recent evidence demonstrates heterogeneity among CD8+ T cells during chronic infection, developmental relationships and mechanisms underlying their fate decisions remain incompletely understood. Using single-cell RNA and TCR sequencing, we t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::255f1b52f5b23cccfa294b26631b5c3b
https://pubmed.ncbi.nlm.nih.gov/36315049
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3
Digitized Braille cell: a novel solution for visually impaired
Autor: Nishanth S. Murthy, C. Sandesh, S. Gayathri, Nikhil S. Joshi, Mukundh Balabhadra, B. A. Sujathakumari
Publikováno v: International Journal of Information Technology. 13:1201-1208
Braille is a system of raised dots. Normal human beings read braille code with their eyes whereas visually impaired person with their fingers. Braille is not a language but is a code. With Braille code many languages such as English, French, Spanish
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6889f2ffd74f59741927b048ee4ead07
https://doi.org/10.1007/s41870-020-00506-9
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4
Novel Mouse Models for Cancer Immunology
Autor: Kelli A. Connolly, Brittany Fitzgerald, Martina Damo, Nikhil S. Joshi
Publikováno v: Annu Rev Cancer Biol
Mouse models of cancer immunology provide excellent systems in which to study and test biological mechanisms of the immune response against cancer. Historically, these models were designed to have different strengths based on the current major resear
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ffc486e830a49022c646537ab53e0e6
https://europepmc.org/articles/PMC9979244/
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5
Abstract A46: Neoantigen-driven B and T follicular helper cell collaboration promotes anti-tumor CD8 T cell responses
Autor: Can Cui, Joseph Craft, Nikhil S. Joshi
Publikováno v: Cancer Immunology Research. 10:A46-A46
CD4 T follicular helper (TFH) cells and B cells are essential components of germinal center (GC) response, but the importance and mechanisms of TFH-B cell collaborations in malignancy are unclear. The presence of TFH, B cells and GC has been associat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::420ae2f5f3ba70a41e5fbb851390ffb7
https://doi.org/10.1158/2326-6074.tumimm22-a46
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7
A mouse model for the study of anti-tumor T cell responses in Kras-driven lung adenocarcinoma
Autor: Gena G. Foster, Ivana William, Julie F. Cheung, Brittany Fitzgerald, Nikhil S. Joshi, Can Cui, Kelli A. Connolly, Eric Fagerberg, Noah I. Hornick, Dylan L. Mariuzza
Publikováno v: Cell reports methods
SUMMARY Kras-driven lung adenocarcinoma (LUAD) is the most common lung cancer. A significant fraction of patients with Kras-driven LUAD respond to immunotherapy, but mechanistic studies of immune responses against LUAD have been limited because of a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::388e697d2e0be1e21fb9e170b3ed3897
https://pubmed.ncbi.nlm.nih.gov/34632444
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8
A reservoir of stem-like CD8
Autor: Kelli A, Connolly, Manik, Kuchroo, Aarthi, Venkat, Achia, Khatun, Jiawei, Wang, Ivana, William, Noah I, Hornick, Brittany L, Fitzgerald, Martina, Damo, Moujtaba Y, Kasmani, Can, Cui, Eric, Fagerberg, Isabel, Monroy, Amanda, Hutchins, Julie F, Cheung, Gena G, Foster, Dylan L, Mariuzza, Mursal, Nader, Hongyu, Zhao, Weiguo, Cui, Smita, Krishnaswamy, Nikhil S, Joshi
Publikováno v: Sci Immunol
“Stem-like” TCF1(+) CD8(+) T cells (T(SL)) are necessary for long-term maintenance of T cell responses and the efficacy of immunotherapy but, as tumors contain signals that should drive T-cell terminal-differentiation, how these cells are maintai
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3e6e92f53c1eaaa1f1c6306e7c6ecb7b
https://pubmed.ncbi.nlm.nih.gov/34597124
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10
Enhanced adaptive immune responses in lung adenocarcinoma through natural killer cell stimulation
Autor: Banu Eskiocak, Celeste Dang, Da-Yae Lee, Ryan Kohn, Tyler Jacks, Michel DuPage, Leah Marie Schmidt, Nikhil S. Joshi
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Significance T cell-targeted therapies are effective against lung cancer only in a fraction of patients, highlighting a need for complimentary approaches. In genetically engineered lung cancer in mice, stimulation of natural killer cells in establish
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a76a0e6e3cedd3eccaea5cbd5579e07
https://doi.org/10.1073/pnas.1904253116
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