SUMO is a pervasive regulator of meiosis

Autor: Nikhil R Bhagwat, Shannon N Owens, Masaru Ito, Jay V Boinapalli, Philip Poa, Alexander Ditzel, Srujan Kopparapu, Meghan Mahalawat, Owen Richard Davies, Sean R Collins, Jeffrey R Johnson, Nevan J Krogan, Neil Hunter

Publikováno v: eLife, Vol 10 (2021)

Protein modification by SUMO helps orchestrate the elaborate events of meiosis to faithfully produce haploid gametes. To date, only a handful of meiotic SUMO targets have been identified. Here, we delineate a multidimensional SUMO-modified meiotic pr

Externí odkaz: https://doaj.org/article/90c2bf15fb2845509fcf913b161b4107

Supplementary Table 2 from Immunodetection of DNA Repair Endonuclease ERCC1-XPF in Human Tissue

Autor: Laura J. Niedernhofer, Richard D. Wood, Rajiv Dhir, Marie B. Acquafondata, Vera Y. Roginskaya, Nikhil R. Bhagwat

Supplementary Table 2 from Immunodetection of DNA Repair Endonuclease ERCC1-XPF in Human Tissue

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01e9875c09eb416f54c7487174a6b77d
https://doi.org/10.1158/0008-5472.22377794.v1

SUMO is a pervasive regulator of meiosis

Autor: Owen R. Davies, Jay V Boinapalli, Meghan Mahalawat, Masaru Ito, Shannon N Owens, Srujan Kopparapu, Sean R. Collins, Jeffrey R. Johnson, Neil Hunter, Alexander Ditzel, Nikhil R. Bhagwat, Nevan J. Krogan, Philip Poa

Publikováno v: eLife, Vol 10 (2021)
eLife
Bhagwat, N R, Owens, S N, Ito, M, Boinapalli, J V, Poa, P, Ditzel, A, Kopparapu, S, Mahalawat, M, Davies, O R, Collins, S R, Johnson, J R, Krogan, N J & Hunter, N 2021, ' SUMO is a pervasive regulator of meiosis ', eLIFE, vol. 10, e57720 . https://doi.org/10.7554/eLife.57720

Protein modification by SUMO helps orchestrate the elaborate events of meiosis to faithfully produce haploid gametes. To date, only a handful of meiotic SUMO targets have been identified. Here, we delineate a multidimensional SUMO-modified meiotic pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65549c9ae5bae07c546e93b221d06038
https://escholarship.org/uc/item/1mr9x0w4

SUMO fosters assembly and functionality of the MutSγ complex to facilitate meiotic crossing over

Autor: Wei He, Nikhil R. Bhagwat, Kathy Gyehyun Lee, Michael Moezpoor, Gerrik F. Verhees, Ye Yang, Andriana Snyder, Sudipta Lahiri, Shashank Shastry, Zane Lombardo, Daniel Painter, Pritha Roy, Dhananjaya S. Kulkarni, Lilly Alocozy, Jiaming Zhuo, Neil Hunter, Ishita Mukerji, Brian Quang Dang

Publikováno v: Dev Cell

Crossing over is essential for chromosome segregation during meiosis. Protein modification by SUMO is implicated in crossover control, but pertinent targets have remained elusive. Here we identify Msh4 as a target of SUMO-mediated crossover regulatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::231bb1c596dc6f0a96a760faec95a4ea
https://doi.org/10.1016/j.devcel.2021.06.012

Regulated Proteolysis of MutSγ Controls Meiotic Crossing Over

Autor: Petr Cejka, Xiangyu Chen, Junxi Wang Bragg, Harrison S. Manasca, Shangming Tang, Yunmei Ma, Dhananjaya S. Kulkarni, Wei He, Gerrik F. Verhees, Nancy M. Hollingsworth, Lepakshi Ranjha, Christa Baker, Nikhil R. Bhagwat, Maria A.W. Chang, Christie Hall, Neil Hunter, H.B.D. Prasada Rao

Publikováno v: Mol Cell
Molecular cell, vol 78, iss 1
Molecular Cell

Summary Crossover recombination is essential for accurate chromosome segregation during meiosis. The MutSγ complex, Msh4-Msh5, facilitates crossing over by binding and stabilizing nascent recombination intermediates. We show that these activities ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ac03b086eefa7e2600235682f1c641a
https://doi.org/10.1016/j.molcel.2020.02.001