Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Nikhil Panicker"'
Autor:
Richard Gordon, Matthew L. Neal, Jie Luo, Monica R. Langley, Dilshan S. Harischandra, Nikhil Panicker, Adhithiya Charli, Huajun Jin, Vellareddy Anantharam, Trent M. Woodruff, Qun-Yong Zhou, Anumantha G. Kanthasamy, Arthi Kanthasamy
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-18 (2016)
Prokineticin-2 (PK2) is a secreted protein involved in a number of physiological functions. Here, the authors find that PK2 expression increases in surviving DA neurons from Parkinson's disease patients, and show it protects against dopaminergic dege
Externí odkaz:
https://doaj.org/article/b8d6e03a18c04bd3a3c79b515e12e20f
Autor:
Richard Gordon, Neeraj Singh, Vivek Lawana, Anamitra Ghosh, Dilshan S. Harischandra, Huajun Jin, Colleen Hogan, Souvarish Sarkar, Dharmin Rokad, Nikhil Panicker, Vellareddy Anantharam, Anumantha G. Kanthasamy, Arthi Kanthasamy
Publikováno v:
Neurobiology of Disease, Vol 93, Iss , Pp 96-114 (2016)
Chronic microglial activation has been linked to the progressive degeneration of the nigrostriatal dopaminergic neurons evidenced in Parkinson's disease (PD) pathogenesis. The exact etiology of PD remains poorly understood. Although both oxidative st
Externí odkaz:
https://doaj.org/article/ec3a7ae44df5411d81cc55315cddb58c
Publikováno v:
CNS drugs. 36(12)
Parkinson's disease is the second most prevalent neurodegenerative disease and contributes significantly to morbidity globally. Currently, no disease-modifying therapies exist to combat this disorder. Insights from the molecular and cellular pathobio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ba4204b5656bcb4fc0042e5aa8292bd
https://pubmed.ncbi.nlm.nih.gov/36378485
https://pubmed.ncbi.nlm.nih.gov/36378485
Autor:
Jared T. Hinkle, Jaimin Patel, Nikhil Panicker, Senthilkumar S. Karuppagounder, Devanik Biswas, Bonn Belingon, Rong Chen, Saurav Brahmachari, Olga Pletnikova, Juan C. Troncoso, Valina L. Dawson, Ted M. Dawson
Publikováno v:
Proceedings of the National Academy of Sciences. 119
In idiopathic Parkinson’s disease (PD), pathologic αSyn aggregates drive oxidative and nitrative stress that may cause genomic and mitochondrial DNA damage. These events are associated with activation of the cyclic GMP-AMP synthase (cGAS)/stimulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::157c663f1045d4bdd2858a57b57e3c8f
https://doi.org/10.1073/pnas.2118819119
https://doi.org/10.1073/pnas.2118819119
Autor:
Sheila K. Pirooznia, Hu Wang, Nikhil Panicker, Manoj Kumar, Stewart Neifert, Mohamad Aasif Dar, Evan Lau, Bong Gu Kang, Javier Redding-Ochoa, Juan C. Troncoso, Valina L. Dawson, Ted M. Dawson
Publikováno v:
Science Advances. 8
Mutations in PINK1 and parkin highlight the mitochondrial axis of Parkinson’s disease (PD) pathogenesis. PINK1/parkin regulation of the transcriptional repressor PARIS bears direct relevance to dopamine neuron survival through augmentation of PGC-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::783cd0ed73d973cd2c444c1f5f271b0c
https://doi.org/10.1126/sciadv.abh1824
https://doi.org/10.1126/sciadv.abh1824
Autor:
Nikhil Panicker, Tae-In Kam, Hu Wang, Stewart Neifert, Shih-Ching Chou, Manoj Kumar, Saurav Brahmachari, Aanishaa Jhaldiyal, Jared T. Hinkle, Fatih Akkentli, Xiaobo Mao, Enquan Xu, Senthilkumar S. Karuppagounder, Eric T. Hsu, Sung-Ung Kang, Olga Pletnikova, Juan Troncoso, Valina L. Dawson, Ted M. Dawson
Publikováno v:
Neuron. 110(15)
Parkinson's disease (PD) is mediated, in part, by intraneuronal accumulation of α-synuclein aggregates andsubsequent death of dopamine (DA) neurons in the substantia nigra pars compacta (SNpc). Microglial hyperactivation of the NOD-like receptor pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e71ad779e7f6589ab8ba8fc4d9514428
https://pubmed.ncbi.nlm.nih.gov/35926449
https://pubmed.ncbi.nlm.nih.gov/35926449
Autor:
Huajun Jin, Hariharan Saminathan, Shivani Ghaisas, Manikandan Samidurai, Nikhil Panicker, Valina L. Dawson, Dharmin Rokad, Tae In Kam, Anumantha G. Kanthasamy, Monica R. Langley, Adhithiya Charli, Dilshan S. Harischandra, Arthi Kanthasamy, Olga Pletnikova, Matthew Neal, Souvarish Sarkar, Ted M. Dawson, Vellareddy Anantharam
Publikováno v:
The Journal of Experimental Medicine
Fyn kinase mediates aggregated α-synuclein (αSyn) uptake as well as αSyn-mediated proinflammatory signaling in microglia, leading to NLRP3 inflammasome activation and neuroinflammation in Parkinson’s disease.
Persistent microglia-mediated n
Persistent microglia-mediated n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bf9a3ae4bb1a5fe9de8fe5dd35e8d28
https://doi.org/10.1084/jem.20182191
https://doi.org/10.1084/jem.20182191
Publikováno v:
J Cell Biol
Parkinson’s disease (PD) is a progressive neurodegenerative disorder resulting from the death of dopamine neurons in the substantia nigra pars compacta. Our understanding of PD biology has been enriched by the identification of genes involved in it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0453b75db6e386763ebccfed3b9ed67
https://doi.org/10.1083/jcb.202012095
https://doi.org/10.1083/jcb.202012095
Autor:
Jie Luo, Vellareddy Anantharam, Poojya Anantharam, Srikant Rangaraju, Anumantha G. Kanthasamy, Heike Wulff, Dilshan S. Harischandra, Neeraj Kumar Singh, Bharathi N. Palanisamy, Sireesha Manne, Vikrant Singh, Lee-Way Jin, Nikhil Panicker, Hai M. Nguyen, Matthew Neal, Huajun Jin, Muhammet Ay, Dharmin Rokad, Ahmed Abdalla, Souvarish Sarkar, Monica R. Langley, Adhithiya Charli, Emir Malovic, Michelle Gabrielle
Publikováno v:
J Clin Invest
Characterization of the key cellular targets contributing to sustained microglial activation in neurodegenerative diseases, including Parkinson’s disease (PD), and optimal modulation of these targets can provide potential treatments to halt disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::359085d0ada16452f1a9ff47a5a891a2
https://doi.org/10.1172/jci136174
https://doi.org/10.1172/jci136174
