Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Nikhil K. Tulsian"'
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Acrodysostosis represents a group of rare genetic disorders characterized by defective skeletal development and is often accompanied by intellectual disabilities. Mutations in the 3′5′cyclic AMP (cAMP)-dependent protein kinase (PKA) type I regula
Externí odkaz:
https://doaj.org/article/5116d8c96920407f986b9c68570756ed
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 10, p 5242 (2021)
Phosphodiesterases (PDEs) hydrolyze cyclic nucleotides to modulate multiple signaling events in cells. PDEs are recognized to actively associate with cyclic nucleotide receptors (protein kinases, PKs) in larger macromolecular assemblies referred to a
Externí odkaz:
https://doaj.org/article/cd50006c73774011bebed543b43e35be
Autor:
Palur V Raghuvamsi, Nikhil K Tulsian, Firdaus Samsudin, Xinlei Qian, Kiren Purushotorman, Gu Yue, Mary M Kozma, Wong Y Hwa, Julien Lescar, Peter J Bond, Paul A MacAry, Ganesh S Anand
Publikováno v:
eLife, Vol 10 (2021)
The spike (S) protein is the main handle for SARS-CoV-2 to enter host cells via surface angiotensin-converting enzyme 2 (ACE2) receptors. How ACE2 binding activates proteolysis of S protein is unknown. Here, using amide hydrogen–deuterium exchange
Externí odkaz:
https://doaj.org/article/edbdeb7b5ce14846aca9ce972b3d86d3
Autor:
Rachel Harold, Nikhil K. Tulsian, Rajesh Narasimamurthy, Noelle Yaitanes, Maria G. Ayala Hernandez, Hsiau-Wei Lee, David M. Virshup, Carrie L. Partch
SummaryCasein kinase 1 δ (CK1δ) controls essential biological processes, including circadian rhythms and Wnt signaling, but how its activity is regulated is not well understood. CK1δ is inhibited by autophosphorylation of its intrinsically disorde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::caff44d44467f8309af522754415c828
https://doi.org/10.1101/2023.04.24.538174
https://doi.org/10.1101/2023.04.24.538174
Autor:
Lorena Zuzic, Firdaus Samsudin, Aishwary T. Shivgan, Palur V. Raghuvamsi, Jan K. Marzinek, Alister Boags, Conrado Pedebos, Nikhil K. Tulsian, Jim Warwicker, Paul MacAry, Max Crispin, Syma Khalid, Ganesh S. Anand, Peter J. Bond
The COVID-19 pandemic has prompted a rapid response in vaccine and drug development. Herein, we modeled a complete membrane-embedded SARS-CoV-2 spike glycoprotein and used molecular dynamics simulations with benzene probes designed to enhance discove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed1b6cc5e74ddaabe57b001fb0c04e3c
https://eprints.soton.ac.uk/469647/
https://eprints.soton.ac.uk/469647/
Autor:
Dipti Thakkar, Shalini Paliwal, Bhushan Dharmadhikari, Siyu Guan, Lillian Liu, Shreya Kar, Nikhil K Tulsian, Joshua J Gruber, Leah DiMascio, Konrad H Paszkiewicz, Piers J Ingram, Jerome D Boyd-Kirkup
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 2 (2022)
BackgroundDespite significant progress in cancer immunotherapy in recent years, resistance to existing immune checkpoint therapies (ICT) is common. V-domain Ig suppressor of T cell activation (VISTA), a predominantly myeloid immune checkpoint regulat
Autor:
Nikhil K. Tulsian, Palur V. Raghuvamsi, Xinlei Qian, Gu Yue, Bhuvaneshwari D/O Shunmuganathan, Firdaus Samsudin, Wong Yee Hwa, Lin Jianqing, Kiren Purushotorman, Mary M. Kozma, Bei Wang, Julien Lescar, Cheng-I Wang, Ganesh S. Anand, Peter J. Bond, Paul A. MacAry
Previous studies on the structural relationship between human antibodies and SARS-CoV-2 have focused on generating static snapshots of antibody complexes with the Spike trimer. However, antibody-antigen interactions are dynamic, with significant bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5f52b056b592f4e77e5529cd1f6e3f8
https://doi.org/10.1101/2021.12.27.474251
https://doi.org/10.1101/2021.12.27.474251
Autor:
Bing Liang Alvin Chew, AN Qi Ngoh, Wint Wint Phoo, Kitti Wing Ki Chan, Zheng Ser, Nikhil K Tulsian, Shiao See Lim, Mei Jie Grace Weng, Satoru Watanabe, Milly M Choy, Jenny Low, Eng Eong Ooi, Christiane Ruedl, Radoslaw M Sobota, Subhash G Vasudevan, Dahai Luo
Publikováno v:
eLife, Vol 12 (2024)
Severe dengue infections are characterized by endothelial dysfunction shown to be associated with the secreted nonstructural protein 1 (sNS1), making it an attractive vaccine antigen and biotherapeutic target. To uncover the biologically relevant str
Externí odkaz:
https://doaj.org/article/7d2b25b34b2d403fb3d814958e7d8555