Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Nikhil K. Acharya"'
Autor:
Joaquin E. Douton, Nikhil K. Acharya, Brooke Stoltzfus, Dongxiao Sun, Patricia S. Grigson, Jennifer E. Nyland
Publikováno v:
Behavioural pharmacology. 33(5)
Substance use disorder is challenging to treat due to its relapsing nature. In the last decade, opioid use disorder has been a threat to public health, being declared an epidemic by the Centers for Disease Control and Prevention. This is a tragic sit
Publikováno v:
Brain research bulletin. 189
Opioid Use Disorder (OUD) is a chronic relapsing disorder that has severe negative impacts on the individual, the family, and the community at large. In 2021, opioids contributed to nearly 70% of all drug overdose deaths in the United States. This nu
Autor:
Nikhil K. Acharya, Jenny M. Brown, Bao Anh Phan, Danielle Wieck, Miles E. Matsen, Dylan M. Rausch, Marie A. Bentsen, Huzaifa Wasanwala, Anna Secher, Peng Zhai, Tune H. Pers, Jarrad M. Scarlett, Nicole E. Richardson, Xin Zhao, Michael W. Schwartz, Gregory J. Morton
Publikováno v:
iScience
Brown, J M, Bentsen, M A, Rausch, D M, Phan, B A, Wieck, D, Wasanwala, H, Matsen, M E, Acharya, N, Richardson, N E, Zhao, X, Zhai, P, Secher, A, Morton, G J, Pers, T H, Schwartz, M W & Scarlett, J M 2021, ' Role of hypothalamic MAPK/ERK signaling and central action of FGF1 in diabetes remission ', iScience, vol. 24, no. 9, 102944 . https://doi.org/10.1016/j.isci.2021.102944
iScience, Vol 24, Iss 9, Pp 102944-(2021)
Brown, J M, Bentsen, M A, Rausch, D M, Phan, B A, Wieck, D, Wasanwala, H, Matsen, M E, Acharya, N, Richardson, N E, Zhao, X, Zhai, P, Secher, A, Morton, G J, Pers, T H, Schwartz, M W & Scarlett, J M 2021, ' Role of hypothalamic MAPK/ERK signaling and central action of FGF1 in diabetes remission ', iScience, vol. 24, no. 9, 102944 . https://doi.org/10.1016/j.isci.2021.102944
iScience, Vol 24, Iss 9, Pp 102944-(2021)
Summary The capacity of the brain to elicit sustained remission of hyperglycemia in rodent models of type 2 diabetes following intracerebroventricular (icv) injection of fibroblast growth factor 1 (FGF1) is well established. Here, we show that follow
Autor:
Nikhil K. Acharya, Gregory J. Morton, Miles E. Matsen, Michael W. Schwartz, Richard N. Bergman, Darko Stefanovski, Kenjiro Muta
Publikováno v:
Brain Research. 1710:136-145
Normal glucose homeostasis depends on the capacity of pancreatic β-cells to adjust insulin secretion in response to a change of tissue insulin sensitivity. In cold environments, for example, the dramatic increase of insulin sensitivity required to e
Autor:
Kenjiro Muta, Rasmus Jorgensen, Karl J. Kaiyala, Masakazu Shiota, Gregory J. Morton, Darko Stefanovski, Jennifer M. Rojas, Richard N. Bergman, Francesca Piccinini, Jarrad M. Scarlett, Jenny M. Brown, Thomas Hoeg-Jensen, Camilla Ingvorsen, Michael W. Schwartz, Nikhil K. Acharya, Anna Secher, Miles E. Matsen
Publikováno v:
Diabetes
We recently reported that in rodent models of type 2 diabetes (T2D), a single intracerebroventricular (icv) injection of fibroblast growth factor 1 (FGF1) induces remission of hyperglycemia that is sustained for weeks. To clarify the peripheral mecha
Autor:
Jenny M. Brown, Gregory J. Morton, Jarrad M. Scarlett, Anna Secher, Michael W. Schwartz, Marie A. Bentsen, Tune H. Pers, Nicole E. Richardson, Dylan M. Rausch, Nikhil K. Acharya, Danielle Wieck, Huzaifa Wasanwala, Miles E. Matsen, Xin Zhao, Bao Anh Phan, Peng Zhai
Publikováno v:
SSRN Electronic Journal.
The capacity of the brain to elicit sustained remission of hyperglycemia in rodent models of type 2 diabetes following intracerebroventricular (icv) injection of fibroblast growth factor 1 (FGF1) is well established. Here, we show that following icv
Autor:
Iriscilla Ayala, Marcel Fourcaudot, Nikhil K. Acharya, Christopher P. Jenkinson, Sami Heikkinen, Xi Chen, Luke Norton, Chris E. Shannon
Publikováno v:
Diabetes
The gene encoding for transcription factor 7-like 2 (TCF7L2) is the strongest type 2 diabetes mellitus (T2DM) candidate gene discovered to date. The TCF7L2 protein is a key transcriptional effector of the Wnt/β-catenin signaling pathway, which is an
Autor:
Richard N. Bergman, Karl J. Kaiyala, Steven E. Kahn, Darko Stefanovski, Miles E. Matsen, Francesca Piccinini, Gregory J. Morton, Jarrad M. Scarlett, Gerald J. Taborsky, Michael W. Schwartz, Nikhil K. Acharya, Jarrell T. Nelson, Kenjiro Muta, Jennifer M. Rojas
Publikováno v:
Diabetes
Dynamic adjustment of insulin secretion to compensate for changes of insulin sensitivity that result from alteration of nutritional or metabolic status is a fundamental aspect of glucose homeostasis. To investigate the role of the brain in this coupl
Autor:
Miles E. Matsen, Eddie L. Khav, Rasmus Jorgensen, Bao Anh N. Phan, Michael W. Schwartz, Nikhil K. Acharya, Jenny M. Brown, Jarrad M. Scarlett, Hong T. Nguyen, Anna Secher, Gregory J. Morton
Publikováno v:
Diabetes. 67
The brain is implicated in the antidiabetic effects of members of the fibroblast growth factor (FGF) peptide family. Previously, we reported that a single intracerebroventricular (icv) injection of FGF-1 induces remission of hyperglycemia that is sus
Autor:
Marcel Fourcaudot, Xi Chen, Ralph A. DeFronzo, Nikhil K. Acharya, Sami Heikkinen, Luke Norton
Publikováno v:
Nucleic Acids Research
In the liver Wnt-signaling contributes to the metabolic fate of hepatocytes, but the precise role of the TCF7L2 in this process is unknown. We employed a temporal RNA-Seq approach to examine gene expression 3–96 h following Tcf7l2 silencing in rat