Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Nikesh Desai"'
Autor:
Veena R. Agarwal, Somesh Sharma, Avinash More, Anagha Damre, Rajiv Sharma, Sanjay Kumar, Nilambari Yewalkar, Vijaykumar Deore, Lakshmi S. Kolla, Julie Bose, Sarika Chaudhari, Nikesh Desai, Magesh Venkatraman, Asavari Joshi, Srinivas Boreddy, Dimple R. Bhatia, Archana Jalota-Badhwar
Supplementary Table S1; Supplementary Figures S1-S2. Supplementary Table 1. A) IC50 value of P7170 in pan-PI3K. B) Kinase inhibition data (ProQinase) of P7170 at 250 nM and 1. 5 μM.C) Kinase inhibition profile (KINOMEscan; 320 kinases) of P717
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d25173fc0ee98eb8b60c1909b4e3f991
https://doi.org/10.1158/1535-7163.22502247.v1
https://doi.org/10.1158/1535-7163.22502247.v1
Autor:
Asavari Joshi, Anagha Damre, Veena R Agarwal, Magesh Venkatraman, Rajiv Sharma, Nikesh Desai, Julie Bose, Srinivas Reddy Boreddy, Lakshmi Sireesha Kolla, Nilambari Yewalkar, Archana Jalota-Badhwar, Sarika Chaudhari, Avinash More, Vijaykumar Deore, Somesh Sharma, Dimple Bhatia, Sanjay Kumar
Publikováno v:
Molecular Cancer Therapeutics. 14:1095-1106
The mTOR pathway is often upregulated in cancer and thus intensively pursued as a target to design novel anticancer therapies. Approved and emerging drugs targeting the mTOR pathway have positively affected the clinical landscape. Recently, activin r
Autor:
Mandar R. Bhonde, Kalpana Joshi, Vijaykumar Deore, Nikesh Desai, Amol Padgaonkar, Asavari Joshi, Anagha Damre, Pradeep Kumar, Manoj V. Lohar, Pallavi Godse, Ramswaroop Mundada, Dimple Bhatia, Rajiv Sharma, Nilambari Yewalkar, Sanjay Kumar, Sonal M Manohar
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 13:1460-1466
Hypoxia-inducible factor-1α (HIF-1α) and signal transducer and activator of transcription 3 (STAT3) are transcription factors and are activated in response to hypoxia. Both HIF-1α and STAT3 regulate various aspects of cancer biology such as cell s
Autor:
Pallavi, Godse, Pramod, Kumar, Nilambari, Yewalkar, Vijaykumar, Deore, Manoj, Lohar, Ramswaroop, Mundada, Amol, Padgaonkar, Sonal, Manohar, Asavari, Joshi, Dimple, Bhatia, Nikesh, Desai, Anagha, Damre, Mandar, Bhonde, Kalpana, Joshi, Rajiv, Sharma, Sanjay, Kumar
Publikováno v:
Anti-cancer agents in medicinal chemistry. 13(9)
Hypoxia-inducible factor-1α (HIF-1α) and signal transducer and activator of transcription 3 (STAT3) are transcription factors and are activated in response to hypoxia. Both HIF-1α and STAT3 regulate various aspects of cancer biology such as cell s
Autor:
Vijaykumar Deore, Shruta S. Dadarkar, Pooja Bhatt, Dimple Bhatia, Kumar V.S. Nemmani, Nilesh M. Dagia, Sanjay Kumar, Mandar R. Bhonde, Abhijit Roychowdhury, Ravindra Dattatraya Gupte, Nilambari Yewalkar, Somesh Sharma, Nikesh Desai, Mahesh G. Jadhav, Ram A. Vishwakarma, Aditi Amol Tannu
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(11)
A series of novel cyanopyridyl based molecules ( 1 – 14 ) were designed, synthesized and probed for inhibition of mammalian target of rapamycin (mTOR) activity. Compound 14 was found to be a potent inhibitor of mTOR activity as assessed by enzyme-l
Autor:
Sanjay Kumar, Somesh Sharma, Nilesh M Dagia, Dimple Bhatia, Aditi Amol Tannu, Ram A. Vishwakarma, Mahesh G. Jadhav, Nilambari Yewalkar, Shruta Dadarkar, Vijaykumar Deore, Nikesh Desai, Pooja Bhatt, Ravindra Dattatraya Gupte, Mandar R. Bhonde
Publikováno v:
American journal of physiology. Gastrointestinal and liver physiology. 295(6)
Ulcerative colitis is an autoimmune-inflammatory disease characterized by increased proliferation of colonic epithelial cells, dysregulation of signal transduction pathways, elevated mucosal T cell activation, increased production of proinflammatory
Autor:
Julie Bose, Lakshmi Sireesha Kolla, Somesh Sharma, Asavari Joshi, Anagha Damre, Nikesh Desai, Sarika Chaudhari, Sanjay Kumar, Parkash S. Gill, Magesh Venkataraman, Dimple Bhatia, Rajiv P. Sharma, Nilambari Yewalkar, Veena R Agarwal, Avinash More, Vijaykumar Deore
Publikováno v:
Cancer Research. 72:3742-3742
The PI3K/mTOR pathway plays an important role in regulating cancer cell proliferation, growth, survival and metabolism. Activation of the PI3K/mTOR pathway by multiple mechanisms is one of the most frequently observed defects in human malignancies. T