Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Nika Rajabian"'
Autor:
Pihu Mehrotra, James Jablonski, John Toftegaard, Yali Zhang, Shahryar Shahini, Jianmin Wang, Carey W. Hung, Reilly Ellis, Gabriella Kayal, Nika Rajabian, Song Liu, Kelly C. S. Roballo, Susan B. Udin, Stelios T. Andreadis, Kirkwood E. Personius
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Peripheral Nerve Injuries (PNI) affect more than 20 million Americans and severely impact quality of life by causing long-term disability. PNI is characterized by nerve degeneration distal to the site of nerve injury resulting in long period
Externí odkaz:
https://doaj.org/article/b6d34f0cfb5e4f448addffc2432a0236
Autor:
Debanik Choudhury, Na Rong, Hamsa Vardini Senthil Kumar, Sydney Swedick, Ronel Z. Samuel, Pihu Mehrotra, John Toftegaard, Nika Rajabian, Ramkumar Thiyagarajan, Ashis K. Podder, Yulun Wu, Shahryar Shahini, Kenneth L. Seldeen, Bruce Troen, Pedro Lei, Stelios T. Andreadis
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113738- (2024)
Summary: Mitochondrial dysfunction is a hallmark of cellular senescence, with the loss of mitochondrial function identified as a potential causal factor contributing to senescence-associated decline in cellular functions. Our recent findings revealed
Externí odkaz:
https://doaj.org/article/7e0989fdc4cd4210b9b77af2703db105
Autor:
Nika Rajabian, Izuagie Ikhapoh, Shahryar Shahini, Debanik Choudhury, Ramkumar Thiyagarajan, Aref Shahini, Joseph Kulczyk, Kendall Breed, Shilpashree Saha, Mohamed Alaa Mohamed, Susan B. Udin, Aimee Stablewski, Kenneth Seldeen, Bruce R. Troen, Kirkwood Personius, Stelios T. Andreadis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Aged myoblasts suffer from impaired glycolysis and insulin resistance, but increase methionine catabolism, possibly to meet energetic demands. Here, authors show that inhibiting methionine metabolism via NANOG reprogramming or MAT2A inhibition restor
Externí odkaz:
https://doaj.org/article/20d14dcf72624910a7c1176a420cedc0
Autor:
Mohamed Alaa Mohamed, Aref Shahini, Nika Rajabian, Julia Caserto, Ahmed M.A. El-Sokkary, Magda A. Akl, Stelios T. Andreadis, Chong Cheng
Publikováno v:
Bioactive Materials, Vol 6, Iss 7, Pp 2120-2133 (2021)
Biodegradable elastomers are important emerging biomaterials for biomedical applications, particularly in the area of soft-tissue engineering in which scaffolds need to match the physicochemical properties of native tissues. Here, we report novel fas
Externí odkaz:
https://doaj.org/article/d52b7429bb4343ee912e28d8ef2fc017
Autor:
Aref Shahini, Kalyan Vydiam, Debanik Choudhury, Nika Rajabian, Thy Nguyen, Pedro Lei, Stelios T. Andreadis
Publikováno v:
Stem Cell Research, Vol 30, Iss , Pp 122-129 (2018)
Skeletal muscle (SkM) regeneration relies on the activity of myogenic progenitors that reside beneath the basal lamina of myofibers. Here, we describe a protocol for the isolation of the SkM progenitors from young and old mice by exploiting their out
Externí odkaz:
https://doaj.org/article/1bb73be2c25f4a04b72555be43c74f98
Autor:
Mohamed Alaa Mohamed, Lingyue Yan, Aref Shahini, Nika Rajabian, Amin Jafari, Stelios T. Andreadis, Yun Wu, Chong Cheng
Publikováno v:
ACS Applied Bio Materials. 5:4779-4792
The worldwide steady increase in the number of cancer patients motivates the development of innovative drug delivery systems for combination therapy as an effective clinical modality for cancer treatment. Here, we explored a design concept based on p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7aced89bc6d1a29a2a2aa45eda2e83b
https://doi.org/10.1021/acsabm.2c00464
https://doi.org/10.1021/acsabm.2c00464
Autor:
Nika Rajabian, Debanik Choudhury, Izuagie Ikhapoh, Shilpashree Saha, Aishwarya S. Kalyankar, Pihu Mehrotra, Aref Shahini, Kendall Breed, Stelios T. Andreadis
Publikováno v:
Aging Cell. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52099edf7f4ff45533f9e42fbf71c383
https://doi.org/10.1111/acel.13764
https://doi.org/10.1111/acel.13764
Autor:
Nika Rajabian, Magda A. Akl, Stelios T. Andreadis, Mohamed Alaa Mohamed, Chong Cheng, Aref Shahini, Ahmed M.A. El-Sokkary, Julia Caserto
Publikováno v:
Bioactive Materials, Vol 6, Iss 7, Pp 2120-2133 (2021)
Bioactive Materials
Bioactive Materials
Biodegradable elastomers are important emerging biomaterials for biomedical applications, particularly in the area of soft-tissue engineering in which scaffolds need to match the physicochemical properties of native tissues. Here, we report novel fas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff32127f8d5467d0e90468dc75dd4772
http://www.sciencedirect.com/science/article/pii/S2452199X20303558
http://www.sciencedirect.com/science/article/pii/S2452199X20303558
Autor:
Debanik Choudhury, Na Rong, Izuagie Ikhapoh, Nika Rajabian, Georgios Tseropoulos, Yulun Wu, Pihu Mehrotra, Ramkumar Thiyagarajan, Aref Shahini, Kenneth L. Seldeen, Bruce R. Troen, Pedro Lei, Stelios T. Andreadis
Publikováno v:
Cell reports. 41(9)
Mitochondrial dysfunction, a hallmark of aging, has been associated with the onset of aging phenotypes and age-related diseases. Here, we report that impaired mitochondrial function is associated with increased glutamine catabolism in senescent human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d05fa712c1900956cdc42584c1f24baa
https://pubmed.ncbi.nlm.nih.gov/36450260
https://pubmed.ncbi.nlm.nih.gov/36450260
Autor:
Kalyan Vydiam, Jennifer Peirick, Song Liu, Aimee Stablewski, Thy Nguyen, Yali Zhang, Debanik Choudhury, Tyler Santarelli, Joseph Kulczyk, Izuagie Attairu Ikhapoh, Kenneth Ladd Seldeen, Stelios T. Andreadis, Pedro Lei, Bruce Robert Troen, Jianmin Wang, Shahryar Shahini, Ramkumar Thiyagarajan, Nika Rajabian, Aref Shahini
Publikováno v:
Science Advances
Description
The embryonic factor NANOG reverses aging hallmarks and rejuvenates senescent skeletal muscle progenitors.
Senescence of myogenic progenitors impedes skeletal muscle regeneration. Here, we show that overexpression of the transcr
The embryonic factor NANOG reverses aging hallmarks and rejuvenates senescent skeletal muscle progenitors.
Senescence of myogenic progenitors impedes skeletal muscle regeneration. Here, we show that overexpression of the transcr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a5e2fdae320f95552dc98b55da84a04
https://pubmed.ncbi.nlm.nih.gov/34516892
https://pubmed.ncbi.nlm.nih.gov/34516892