Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Nika M. Strokappe"'
Autor:
Annemart Koornneef, Kanika Vanshylla, Gijs Hardenberg, Lucy Rutten, Nika M. Strokappe, Jeroen Tolboom, Jessica Vreugdenhil, Karin Feddes-de Boer, Aditya Perkasa, Sven Blokland, Judith A. Burger, Wei-Chiao Huang, Jonathan F. Lovell, Danielle van Manen, Rogier W. Sanders, Roland C. Zahn, Hanneke Schuitemaker, Johannes P. M. Langedijk, Frank Wegmann
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract One of the strategies towards an effective HIV-1 vaccine is to elicit broadly neutralizing antibody responses that target the high HIV-1 Env diversity. Here, we present an HIV-1 vaccine candidate that consists of cobalt porphyrin-phospholipi
Externí odkaz:
https://doaj.org/article/b47f9ae471c641c184638edf81cb1133
Directing HIV-1 for degradation by non-target cells, using bi-specific single-chain llama antibodies
Autor:
Jord C. Stam, Steven de Maat, Dorien de Jong, Mathia Arens, Fenna van Lint, Lavina Gharu, Mark H. van Roosmalen, Rob C. Roovers, Nika M. Strokappe, Ralf Wagner, Alexander Kliche, Hans J. de Haard, Paul M. van Bergen en Henegouwen, Monique Nijhuis, C. Theo Verrips
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract While vaccination against HIV-1 has been so far unsuccessful, recently broadly neutralizing antibodies (bNAbs) against HIV-1 envelope glycoprotein were shown to induce long-term suppression in the absence of antiretroviral therapy in patient
Externí odkaz:
https://doaj.org/article/ffdba455ddae44ce8e6074f6be3806a7
Autor:
Lucy Rutten, Yen-Ting Lai, Sven Blokland, Daphne Truan, Ilona J.M. Bisschop, Nika M. Strokappe, Annemart Koornneef, Danielle van Manen, Gwo-Yu Chuang, S. Katie Farney, Hanneke Schuitemaker, Peter D. Kwong, Johannes P.M. Langedijk
Publikováno v:
Cell Reports, Vol 23, Iss 2, Pp 584-595 (2018)
Summary: The heavily glycosylated native-like envelope (Env) trimer of HIV-1 is expected to have low immunogenicity, whereas misfolded forms are often highly immunogenic. High-quality correctly folded Envs may therefore be critical for developing a v
Externí odkaz:
https://doaj.org/article/f00d8ce16cef4ca2a1504c92e4d9380a
Autor:
Nika M. Strokappe, Miriam Hock, Lucy Rutten, Laura E. Mccoy, Jaap W. Back, Christophe Caillat, Matthias Haffke, Robin A. Weiss, Winfried Weissenhorn, Theo Verrips
Publikováno v:
Antibodies, Vol 8, Iss 2, p 38 (2019)
Broad and potent neutralizing llama single domain antibodies (VHH) against HIV-1 targeting the CD4 binding site (CD4bs) have previously been isolated upon llama immunization. Here we describe the epitopes of three additional VHH groups selected from
Externí odkaz:
https://doaj.org/article/2e8d01ac0ce44807b40322c7b3eaad84
Autor:
Hannah J. Barbian, Julie M. Decker, Frederic Bibollet-Ruche, Rachel P. Galimidi, Anthony P. West, Gerald H. Learn, Nicholas F. Parrish, Shilpa S. Iyer, Yingying Li, Craig S. Pace, Ruijiang Song, Yaoxing Huang, Thomas N. Denny, Hugo Mouquet, Loic Martin, Priyamvada Acharya, Baoshan Zhang, Peter D. Kwong, John R. Mascola, C. Theo Verrips, Nika M. Strokappe, Lucy Rutten, Laura E. McCoy, Robin A. Weiss, Corrine S. Brown, Raven Jackson, Guido Silvestri, Mark Connors, Dennis R. Burton, George M. Shaw, Michel C. Nussenzweig, Pamela J. Bjorkman, David D. Ho, Michael Farzan, Beatrice H. Hahn
Publikováno v:
mBio, Vol 6, Iss 2 (2015)
ABSTRACT Broadly cross-reactive neutralizing antibodies (bNabs) represent powerful tools to combat human immunodeficiency virus type 1 (HIV-1) infection. Here, we examined whether HIV-1-specific bNabs are capable of cross-neutralizing distantly relat
Externí odkaz:
https://doaj.org/article/46821e94c4f84dc3b70247c0404d431a
Autor:
Marika Mikelsaar, Nika M. Strokappe, Lennart Hammarström, Theo Verrips, Kasper Krogh Andersen, Imbi Smidt, Harold Marcotte, Kai Truusalu, Anna Hultberg, Raik-Hiio Mikelsaar
Publikováno v:
Infection and Immunity. 84:395-406
Clostridium difficile is the primary cause of nosocomial antibiotic-associated diarrhea in the Western world. The major virulence factors of C. difficile are two exotoxins, toxin A (TcdA) and toxin B (TcdB), which cause extensive colonic inflammation
Autor:
Nika M. Strokappe, Carolyn J. Edwards, Bianca Bulmer-Thomas, Anna Forsman Quigley, Michael S. Seaman, Theo Verrips, Lucy Rutten, David Davis, Robin Ketteler, Nikita Chander, Daniella Mortier, Laura E. McCoy, Robin A. Weiss
Publikováno v:
The Journal of Experimental Medicine
A heavy chain–only antibody isolated from a llama repeatedly immunized with trimeric HIV-1 Env neutralizes 96% of tested HIV-1 strains.
Llamas (Lama glama) naturally produce heavy chain–only antibodies (Abs) in addition to conventional Abs.
Llamas (Lama glama) naturally produce heavy chain–only antibodies (Abs) in addition to conventional Abs.
Autor:
Lucy Rutten, Nika M. Strokappe, Peter D. Kwong, John R. Mascola, Julie M. Decker, Michael Farzan, Guido Silvestri, Pamela J. Bjorkman, Yaoxing Huang, Dennis R. Burton, Thomas N. Denny, Michel C. Nussenzweig, Gerald H. Learn, Hugo Mouquet, Corrine S. Brown, Laura E. McCoy, Frederic Bibollet-Ruche, Mark Connors, Priyamvada Acharya, Baoshan Zhang, Nicholas F. Parrish, C. Theo Verrips, George M. Shaw, Shilpa S. Iyer, Anthony P. West, Loïc Martin, Robin A. Weiss, David D. Ho, Rachel P. Galimidi, Beatrice H. Hahn, Raven Jackson, Hannah J. Barbian, Yingying Li, Craig S. Pace, Ruijiang Song
Publikováno v:
mBio
mBio, American Society for Microbiology, 2015, 6 (2), ⟨10.1128/mBio.00296-15⟩
mBio, 2015, 6 (2), ⟨10.1128/mBio.00296-15⟩
mBio, Vol 6, Iss 2 (2015)
mBio, American Society for Microbiology, 2015, 6 (2), ⟨10.1128/mBio.00296-15⟩
mBio, 2015, 6 (2), ⟨10.1128/mBio.00296-15⟩
mBio, Vol 6, Iss 2 (2015)
Broadly cross-reactive neutralizing antibodies (bNabs) represent powerful tools to combat human immunodeficiency virus type 1 (HIV-1) infection. Here, we examined whether HIV-1-specific bNabs are capable of cross-neutralizing distantly related simian
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdf2a6b9dcf9987d58e17ba5bd813aa6
https://resolver.caltech.edu/CaltechAUTHORS:20150623-121042719
https://resolver.caltech.edu/CaltechAUTHORS:20150623-121042719
Autor:
Andrea Gorlani, David Lutje Hulsik, Anna Forsman Quigley, Lei Chen, Agnieszka Szynol, Marlén M. I. Aasa-Chapman, Nika M. Strokappe, Robin A. Weiss, Hans de Haard, Theo Verrips
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33298 (2012)
PloS one, vol 7, iss 3
PLoS ONE
PloS one, vol 7, iss 3
PLoS ONE
Many of the neutralising antibodies, isolated to date, display limited activities against the globally most prevalent HIV-1 subtypes A and C. Therefore, those subtypes are considered to be an important target for antibody-based therapy. Variable doma
Autor:
Laura E. McCoy, Simone Battella, Charles Sabin, Alexandre M. J. J. Bonvin, Andreas Hinz, Robin A. Weiss, Michael S. Seaman, David Lutje Hulsik, Lucy Rutten, Miriam Hock, C. Theo Verrips, Alejandra Ramos, Winfried Weissenhorn, Nika M. Strokappe, Pauline Macheboeuf, Johannes P. M. Langedijk, Mohamed El Khattabi, Adrien Favier, Pascal Poignard, Ying-ying Liu, David Davis, Marlén M. I. Aasa-Chapman, Jean-Pierre Simorre, Anna Forsman Quigley
Publikováno v:
PLoS Pathogens
PLoS Pathogens, 2013, 9 (3), pp.e1003202. ⟨10.1371/journal.ppat.1003202⟩
PLoS Pathogens, Vol 9, Iss 3, p e1003202 (2013)
PLoS Pathogens, Public Library of Science, 2013, 9 (3), pp.e1003202. ⟨10.1371/journal.ppat.1003202⟩
PLoS Pathogens, 9(3), 1. Public Library of Science
'PLoS Pathogens ', vol: 9, pages: e1003202-1-e1003202-16 (2013)
PLoS Pathogens, 2013, 9 (3), pp.e1003202. ⟨10.1371/journal.ppat.1003202⟩
PLoS Pathogens, Vol 9, Iss 3, p e1003202 (2013)
PLoS Pathogens, Public Library of Science, 2013, 9 (3), pp.e1003202. ⟨10.1371/journal.ppat.1003202⟩
PLoS Pathogens, 9(3), 1. Public Library of Science
'PLoS Pathogens ', vol: 9, pages: e1003202-1-e1003202-16 (2013)
The membrane proximal external region (MPER) of the HIV-1 glycoprotein gp41 is targeted by the broadly neutralizing antibodies 2F5 and 4E10. To date, no immunization regimen in animals or humans has produced HIV-1 neutralizing MPER-specific antibodie