Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation

Autor: Atiqur Rahman, Katherine M Henry, Kimberly D Herman, Alfred AR Thompson, Hannah M Isles, Claudia Tulotta, David Sammut, Julien JY Rougeot, Nika Khoshaein, Abigail E Reese, Kathryn Higgins, Caroline Tabor, Ian Sabroe, William J Zuercher, Caroline O Savage, Annemarie H Meijer, Moira KB Whyte, David H Dockrell, Stephen A Renshaw, Lynne R Prince

Publikováno v: eLife, Vol 8 (2019)

Neutrophilic inflammation with prolonged neutrophil survival is common to many inflammatory conditions, including chronic obstructive pulmonary disease (COPD). There are few specific therapies that reverse neutrophilic inflammation, but uncovering me

Externí odkaz: https://doaj.org/article/fe7fcfe76891424e9fe5d095f6489f95

Physiologically-Based Pharmacokinetic Models of CYP2D6 Substrate and Inhibitors Nebivolol, Cinacalcet and Mirabegron to Simulate Drug-Drug Interactions

Autor: Peter Kilford, Nika Khoshaein, Roz Southall, Iain Gardner

Publikováno v: European journal of drug metabolism and pharmacokinetics. 47(5)

Index substrates and inhibitors to investigate the role of the polymorphic enzyme, cytochrome P450 (CYP) 2D6, in the metabolism of new compounds have been proposed by regulatory agencies. This work describes the development and verification of physio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c210d1fe4de4492ba05712e3102c8cf
https://pubmed.ncbi.nlm.nih.gov/35840839

Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation

Autor: Hannah M. Isles, Annemarie H. Meijer, Julien Rougeot, Stephen A. Renshaw, Kathryn R. Higgins, Caroline Tabor, Claudia Tulotta, Moira K. B. Whyte, Abigail E Reese, Atiqur Rahman, Aar Thompson, Lynne R. Prince, Kimberly D Herman, Katherine M. Henry, David H. Dockrell, Nika Khoshaein, Caroline O. S. Savage, David Sammut, William J. Zuercher, Ian Sabroe

Publikováno v: eLife
eLife, 8, e50990
Rahman, A, Henry, K M, Herman, K D, Thompson, A A, Isles, H M, Tulotta, C, Sammut, D, Rougeot, J J, Khoshaein, N, Reese, A E, Higgins, K, Tabor, C, Sabroe, I, Zuercher, W J, Savage, C O, Meijer, A H, Whyte, M K, Dockrell, D H, Renshaw, S A & Prince, L R 2019, ' Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation ', eLIFE, vol. 8 . https://doi.org/10.7554/eLife.50990
eLife, Vol 8 (2019)

Neutrophilic inflammation with prolonged neutrophil survival is common to many inflammatory conditions, including chronic obstructive pulmonary disease (COPD). There are few specific therapies that reverse neutrophilic inflammation, but uncovering me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0b59e3fc62c3c598a92603ab84ee828
https://pubmed.ncbi.nlm.nih.gov/31613219