High Birth Weight Is Associated With Obesity and Increased Carotid Wall Thickness in Young Adults

Autor: Mika Kähönen, David S. Celermajer, Michael R. Skilton, Leena Taittonen, Jorma Viikari, Olli T. Raitakari, Ilkka Seppälä, Peter Würtz, Terho Lehtimäki, Tomi Laitinen, Niina Siitonen, Markus Juonala

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 34:1064-1068

Objective— There is some evidence that people born with high birth weight may be at increased risk of cardiovascular disease in adulthood. Details of the underlying mechanisms remain unknown. We sought to determine whether people born large for ges

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57c676e77e1a3ed9cf3ceff61fadee4b
https://doi.org/10.1161/atvbaha.113.302934

Common variants at 6q22 and 17q21 are associated with intracranial volume

Autor: Julie A. Marsh, Meike W. Vernooij, Nicholas J. Timpson, Linda S. Adair, Maksim Struchalin, Kelly S. Benke, Alex P. Zijdenbos, Wiro J. Niessen, Dexter Hadley, André Scherag, Niina Siitonen, Johannes Hedebrand, Helena Schmidt, Iona Y. Millwood, Emily Oken, David S. Knopman, James F. Wilson, H. Rob Taal, Henri A. Vrooman, Karen L. Mohlke, Myriam Fornage, Vilmundur Gudnason, Leslie A. Lange, Sigurdur Sigurdsson, Maria M. Groen-Blokhuis, Diane J. Catellier, Stefan Ropele, Seang Mei Saw, Sylvain Sebert, Alexa S. Beiser, Lyle J. Palmer, Claudia Flexeder, Paul Elliott, George Davey Smith, John W. Holloway, Michel G. Nivard, Mike A. Nalls, Albert V. Smith, Cyrus Cooper, E Zeggini, Terho Lehtimäki, Struan F.A. Grant, Virpi Lindi, Romy Gaillard, B. Gwen Windham, Dennis O. Mook-Kanamori, Claus Holst, Timo A. Lakka, Stéphanie Debette, Liang Kee Goh, Ewan R. Pearson, Tamara B. Harris, Momoko Horikoshi, Jeffrey C. Murray, Mirna Kirin, M. Arfan Ikram, George V. Dedoussis, Anita L. DeStefano, Clifford R. Jack, Alex Lewin, Reedik Maggi, Vincent W. V. Jaddoe, Haukur Gudnason, Hakon Hakonarson, Thomas H. Mosley, Alina Rodriguez, Sudha Seshadri, William M. Meeks, Philip A. Wolf, Gonneke Willemsen, B. Valcarcel, Anke Hinney, Eric A.P. Steegers, Lenore J. Launer, Elina Hyppönen, Lachlan J. M. Coin, Elisabeth Thiering, Mustafa Atalay, W. T. Longstreth, Thorkild I. A. Sørensen, André G. Uitterlinden, Christel M. Middeldorp, Matthew W. Gillman, Ken K. Ong, Oliver S. P. Davis, Monique M.B. Breteler, Wei Ang, Ulla Sovio, Tuomas O. Kilpeläinen, Ioanna Ntalla, Marjo-Riitta Järvelin, Aad van der Lugt, Cornelia M. van Duijn, Cecilia M. Lindgren, Rany M. Salem, Laura H. Coker, Craig E. Pennell, Fernando Rivadeneira, Thomas S. Price, Charles DeCarli, Dorret I. Boomsma, Ellen Aagaard Nohr, Diane Berry, Rhoda Au, Yik Y. Teo, Ville Huikari, Jouke-Jan Hottenga, Matthew Kowgier, Joachim Heinrich, Nienke E. Bergen, Beate St Pourcain, Reinhold Schmidt, C Power, Kalliope Panoutsopoulou, Olli T. Raitakari, Albert Hofman, Mark I. McCarthy, Joel N. Hirschhorn, Olli Simell, Claire M. A. Haworth, Mark A. van Buchem, Anna-Liisa Hartikainen, Berthold Hocher, Debbie A Lawlor, Jennifer Pararajasingham, Toos C. E. M. van Beijsterveldt, David P. Strachan, Hanna Maaria Lakka, Timothy M. Frayling

Publikováno v: Nature Genetics
Nature Genetics, 44(5), 539
Ikram, M A, Fornage, M, Smith, A V, Seshadri, S, Schmidt, R, Debette, S, Vrooman, H A, Sigurdsson, S, Ropele, S, Taal, H R, Mook-Kanamori, D O, Coker, L H, Longstreth, W T, Niessen, W J, DeStefano, A L, Beiser, A, Zijdenbos, A P, Struchalin, M, Jack, C R, Rivadeneira, F, Uitterlinden, A G, Knopman, D S, Hartikainen, A-L, Pennell, C E, Thiering, E, Steegers, E A P, Hakonarson, H, Heinrich, J, Palmer, L J, Jarvelin, M-R, McCarthy, M I, Grant, S F A, St Pourcain, B, Timpson, N J, Smith, G D, Sovio, U, Nalls, M A, Au, R, Hofman, A, Gudnason, H, van der Lugt, A, Harris, T B, Meeks, W M, Vernooij, M W, van Buchem, M A, Catellier, D, Jaddoe, V W V, Gudnason, V & Windham, B G & Wilson, J F 2012, ' Common variants at 6q22 and 17q21 are associated with intracranial volume ', Nature Genetics, vol. 44, no. 5, pp. 539-+ . https://doi.org/10.1038/ng.2245
Nature Genetics, 44(5), 539-544. Nature Publishing Group
Nature Genetics; Vol 44
Nature Genetics, 44(5), 539-+. Nature Publishing Group
Arfan Ikram, M, Fornage, M, Smith, A V, Seshadri, S, Schmidt, R, Debette, S, Vrooman, H A, Sigurdsson, S, Ropele, S, Taal, H R, Mook-Kanamori, D O, Coker, L H, Longstreth, J W T, Niessen, W J, DeStefano, A L, Beiser, A, Zijdenbos, A P, Struchalin, M, Jack, C R, Rivadeneira, F, Uitterlinden, A G, Knopman, D S, Hartikainen, A-L, Pennell, C E, Thiering, E, Steegers, E A P, Hakonarson, H, Heinrich, J, Palmer, L J, Jarvelin, M-R, McCarthy, M I, Grant, S F A, St Pourcain, B, Timpson, N J, Smith, G D, Sovio, U, van Beijsterveldt, C E M, Groen-Blokhuis, M M, Hottenga, J J, Middeldorp, C M, Nivard, M G, Willemsen, G, Boomsma, D I, Nalls, M A, Au, R, Hofman, A, Gudnason, H, van der Lugt, A, Harris, T B, Meeks, W M, Vernooij, M W, van Buchem, M A, Catellier, D, Jaddoe, V W V, Gudnason, V, Windham, B G, Wolf, P A, van Duijn, C M, Mosley, T H, Schmidt, H, Launer, L J, Breteler, M M B & DeCarli, C S 2012, ' Common variants at 6q22 and 17q21 are associated with intracranial volume ', Nature Genetics, vol. 44, no. 5, pp. 539-544 . https://doi.org/10.1038/ng.2245
Nature genetics 44(5), 539-544 (2012). doi:10.1038/ng.2245

During aging, intracranial volume remains unchanged and represents maximally attained brain size, while various interacting biological phenomena lead to brain volume loss. Consequently, intracranial volume and brain volume in late life reflect differ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62d6054f0dfc1871406dd0e078ab45e5

Association of sequence variations in the gene encoding adiponectin receptor 1 (ADIPOR1) with body size and insulin levels. The Finnish Diabetes Prevention Study

Autor: Niina Siitonen, Sirkka Keinänen-Kiukaanniemi, Ursula Mager, Johan G. Eriksson, Valle Tt, Jon Lindstrom, Helena Hämäläinen, M. I. J. Uusitupa, Pirjo Ilanne-Parikka, Markku Laakso, Leena Pulkkinen, J. Tuomilehto

Publikováno v: Diabetologia. 49:1795-1805

Adiponectin is a circulating peptide derived from adipose tissue. It mediates its insulin-sensitising and anti-atherogenic effects on target tissues through two known receptors, adiponectin receptors 1 and 2 (ADIPOR1; ADIPOR2), which are encoded by t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eae920bced18ccc6be4753ad8f7d23cb
https://doi.org/10.1007/s00125-006-0291-7

Plasminogen activator inhitor-1 associates with cardiovascular risk factors in healthy young adults in the Cardiovascular Risk in Young Finns Study

Autor: Antti Jula, Niina Siitonen, Mika Kähönen, Liisa Saarikoski, Jorma S. A. Viikari, Terho Lehtimäki, Britt-Marie Loo, Juho Raiko, Olli T. Raitakari, Maria Wendelin-Saarenhovi, Risto Huupponen, Markus Juonala, Mervi Oikonen

Publikováno v: Atherosclerosis. 224(1)

Hypofibrinolysis displayed by elevated serum plasminogen activator inhibitor 1 (PAI-1) level has been associated with cardiovascular disease (CVD) and its risk factors such as obesity and insulin resistance. However, no studies have examined associat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66cefe5f0e4874cca8a3c389e4f78b0c
https://pubmed.ncbi.nlm.nih.gov/22840426

Physical activity, diet, and incident diabetes in relation to an ADRA2B polymorphism

Autor: Jaana Lindstrúm, David E. Laaksonen, Matti Uusitupa, Piritta Reunanen, Jaakko Tuomilehto, Niina Siitonen, Johan G. Eriksson

Publikováno v: Medicine and science in sports and exercise. 39(2)

Purpose: The 12Glu9 polymorphism of the a2B-adrenergic receptor gene may impair insulin secretion and modify the effects of a lifestyle intervention on the risk of type 2 diabetes, but the interaction with specific lifestyle components is unknown. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::865da8efae5f539bcd1d6ed074dd2c5c
https://pubmed.ncbi.nlm.nih.gov/17277585