Výsledky vyhledávání - "Niina M, Saarinen"

Data from Improved Statistical Modeling of Tumor Growth and Treatment Effect in Preclinical Animal Studies with Highly Heterogeneous Responses In Vivo

Autor: Tero Aittokallio, Matti Poutanen, Sari Mäkelä, Esa Alhoniemi, Mari I. Suominen, Saija Savolainen, Katja Mäkelä, Niina M. Saarinen, Jukka Corander, Teemu D. Laajala

Purpose: Preclinical tumor growth experiments often result in heterogeneous datasets that include growing, regressing, or stable growth profiles in the treatment and control groups. Such confounding intertumor variability may mask the true treatment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a8a5bd4ec2066f6300fef93b5b3301e
https://doi.org/10.1158/1078-0432.c.6520526.v1

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Akademický článek

Novel Lignan and stilbenoid mixture shows anticarcinogenic efficacy in preclinical PC-3M-luc2 prostate cancer model.

Autor: Emrah Yatkin, Lauri Polari, Teemu D Laajala, Annika Smeds, Christer Eckerman, Bjarne Holmbom, Niina M Saarinen, Tero Aittokallio, Sari I Mäkelä

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e93764 (2014)

Prostate cancer is the most common cancer of men in the Western world, and novel approaches for prostate cancer risk reduction are needed. Plant-derived phenolic compounds attenuate prostate cancer growth in preclinical models by several mechanisms,

Externí odkaz: https://doaj.org/article/d14b738881064640b6239fabf98a6d89

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Akademický článek

Flaxseed Ingestion Alters Ratio of Enterolactone Enantiomers in Human Serum

Autor: Niina M. Saarinen, Annika I. Smeds, José L. Peñalvo, Tarja Nurmi, Herman Adlercreutz, Sari Mäkelä

Publikováno v: Journal of Nutrition and Metabolism, Vol 2010 (2010)

Enterolactone (EL) is an enterolignan found in human subjects. In this pilot study, the enantiomeric ratios of serum EL were determined in serum from healthy adults during consumption of habitual diet, and after an 8-day supplementation with flaxseed

Externí odkaz: https://doaj.org/article/f4437171031b4264bb834c24f43f6f1c

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Genistein alone and in combination with the mammalian lignans enterolactone and enterodiol induce estrogenic effects on bone and uterus in a postmenopausal breast cancer mouse model

Autor: Lilian U. Thompson, Niina M. Saarinen, Wendy E. Ward, Krista A. Power, Jianmin Chen

Publikováno v: Bone. 39:117-124

The use of phytoestrogens, such as isoflavones and lignans, for treatment of postmenopausal breast cancer is increasing, but their effects on bone and other major organs are not clear. While the isoflavone genistein (GEN) has been shown to prevent or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f2bde8b87bb0d1eab9fe360570a9a9d
https://doi.org/10.1016/j.bone.2005.12.015

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Sesamin Is One of the Major Precursors of Mammalian Lignans in Sesame Seed (Sesamum indicum) as Observed In Vitro and in Rats

Autor: Zhen Liu, Lilian U. Thompson, Niina M. Saarinen

Publikováno v: The Journal of Nutrition. 136:906-912

Plant lignans occur in many foods, with flaxseed presently recognized as the richest source. Some plant lignans can be converted by intestinal microbiota to the mammalian lignans, enterodiol and enterolactone, which may have protective effects agains

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d8085d8e20baf2b51f04e37852add7f
https://doi.org/10.1093/jn/136.4.906

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Prolonged administration of secoisolariciresinol diglycoside increases lignan excretion and alters lignan tissue distribution in adult male and female rats

Autor: Niina M. Saarinen, Lilian U. Thompson

Publikováno v: The British journal of nutrition. 104(6)

Limited information is available on lignan metabolism and tissue distribution between sexes and the effects of prolonged lignan exposure on tissue concentrations. In the present study, excretion and tissue distribution of lignans were compared after

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b9c989b9ca4810e68e3ad26f3c48681
https://pubmed.ncbi.nlm.nih.gov/20388250

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Flaxseed and soy protein isolate, alone and in combination, differ in their effect on bone mass, biomechanical strength, and uterus in ovariectomized nude mice with MCF-7 human breast tumor xenografts

Autor: Lilian U. Thompson, Krista A. Power, Jianmin Chen, Niina M. Saarinen, Wendy E. Ward

Publikováno v: Journal of toxicology and environmental health. Part A. 70(22)

In our previous study, flaxseed (FS) reduced while soy protein isolate (SPI) stimulated MCF-7 breast tumor growth in ovariectomized mice. In addition, combining SPI and FS resulted in a negation of SPI-induced tumor growth. In this study, the effects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08c79e7830b01e2bd166db5656319c78
https://pubmed.ncbi.nlm.nih.gov/17966060

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