Pancreas Whole Tissue Transcriptomics Highlights the Role of the Exocrine Pancreas in Patients With Recently Diagnosed Type 1 Diabetes

Autor: Tommi Välikangas, Niina Lietzén, Maria K. Jaakkola, Lars Krogvold, Morten C. Eike, Henna Kallionpää, Soile Tuomela, Clayton Mathews, Ivan C. Gerling, Sami Oikarinen, Heikki Hyöty, Knut Dahl-Jorgensen, Laura L. Elo, Riitta Lahesmaa

Publikováno v: Frontiers in Endocrinology, Vol 13 (2022)

Although type 1 diabetes (T1D) is primarily a disease of the pancreatic beta-cells, understanding of the disease-associated alterations in the whole pancreas could be important for the improved treatment or the prevention of the disease. We have char

Externí odkaz: https://doaj.org/article/98e96d37ec7c4f9d9bac17ff104c747d

Serum APOC1 levels are decreased in young autoantibody positive children who rapidly progress to type 1 diabetes

Autor: M. Karoliina Hirvonen, Niina Lietzén, Robert Moulder, Santosh D. Bhosale, Jaakko Koskenniemi, Mari Vähä-Mäkilä, Mirja Nurmio, Matej Orešič, Jorma Ilonen, Jorma Toppari, Riitta Veijola, Heikki Hyöty, Harri Lähdesmäki, Mikael Knip, Lu Cheng, Riitta Lahesmaa

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)

Abstract Better understanding of the early events in the development of type 1 diabetes is needed to improve prediction and monitoring of the disease progression during the substantially heterogeneous presymptomatic period of the beta cell damaging p

Externí odkaz: https://doaj.org/article/b6633caddd254935bc71cb27ff2170c4

Characterization and non-parametric modeling of the developing serum proteome during infancy and early childhood

Autor: Lu Cheng, Aleksandr Peet, Taina Härkönen, Mikael Knip, Robert Moulder, Essi Laajala, Harri Lähdesmäki, Riitta Lahesmaa, Niina Lietzen, Aki Vehtari, Heli Siljander, Vallo Tillmann

Publikováno v: Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)

Children develop rapidly during the first years of life, and understanding the sources and associated levels of variation in the serum proteome is important when using serum proteins as markers for childhood diseases. The aim of this study was to est

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bccfc0f4dc5b884cdd8d8f8c1641170
https://zenodo.org/record/1488659

Imbalance of plasma amino acids, metabolites and lipids in patients with lysinuric protein intolerance (LPI)

Autor: Ismo Mattila, Harri Niinikoski, Maaria Tringham, Olli Simell, Anu Olkku, Johanna Kurko, Heli Nygren, Matej Orešič, Mari Vähä-Mäkilä, Päivi Pöhö, Tuulia Hyötyläinen, Niina Lietzen, Kirsti Näntö-Salonen, Juha Mykkänen, Laura Tanner

Publikováno v: Kurko, J, Tringham, M, Tanner, L, Näntö-Salonen, K, Vähä-Mäkilä, M, Nygren, H, Pöhö, P, Lietzen, N, Mattila, I, Olkku, A, Hyötyläinen, T, Oresic, M, Simell, O, Niinikoski, H & Mykkänen, J 2016, ' Imbalance of plasma amino acids, metabolites and lipids in patients with lysinuric protein intolerance (LPI) ', Metabolism: Clinical and Experimental, vol. 65, no. 9, pp. 1361-1375 . https://doi.org/10.1016/j.metabol.2016.05.012

Background Lysinuric protein intolerance (LPI [MIM 222700]) is an aminoaciduria with defective transport of cationic amino acids in epithelial cells in the small intestine and proximal kidney tubules due to mutations in the SLC7A7 gene. LPI is charac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::767423d7e038f346ef2d839e1bb3cae0
https://cris.vtt.fi/en/publications/47676a01-8ad2-47cb-a5ec-e6bdd48bed4f

Enterovirus-associated changes in blood transcriptomic profiles of children with genetic susceptibility to type 1 diabetes

Autor: Niina, Lietzen, Le T T, An, Maria K, Jaakkola, Henna, Kallionpää, Sami, Oikarinen, Juha, Mykkänen, Mikael, Knip, Riitta, Veijola, Jorma, Ilonen, Jorma, Toppari, Heikki, Hyöty, Riitta, Lahesmaa, Laura L, Elo

Publikováno v: Diabetologia

Aims/hypothesis Enterovirus infections have been associated with the development of type 1 diabetes in multiple studies, but little is known about enterovirus-induced responses in children at risk for developing type 1 diabetes. Our aim was to use ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::309ead945d2067f438881038d1bf5cc7
https://pubmed.ncbi.nlm.nih.gov/29119244