Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Niina, Jalava"'
Autor:
Niina Jalava, Janne Kaskinoro, Hugh Chapman, Miguel Morales, Hanna Metsänkylä, Satu-Maarit Heinonen, Ari-Pekka Koivisto
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3350 (2023)
Transient receptor potential channels C4/C5 are widely expressed in the pain pathway. Here, we studied the putative analgesic efficacy of the highly selective and potent TRPC4/C5 antagonist HC-070 in rats. Inhibitory potency on human TRPC4 was assess
Externí odkaz:
https://doaj.org/article/225d91f559694aa19e93c68611dd103d
Autor:
Jyrki, Lehtimäki, Niina, Jalava, Kaisa, Unkila, John, Aspegren, Antti, Haapalinna, Ullamari, Pesonen
Publikováno v:
European journal of pharmacology. 923
The pharmacological profile of tasipimidine, a novel orally active α
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0ca68f2be81fcf2786e0e13c238ecca1
https://pubmed.ncbi.nlm.nih.gov/35405115
https://pubmed.ncbi.nlm.nih.gov/35405115
Autor:
Shouming, Wang, Anssi, Haikarainen, Antti, Pohjakallio, Julius, Sipilä, Janne, Kaskinoro, Satu, Juhila, Niina, Jalava, Mikko, Koskinen, Marja, Vesajoki, Esa, Kumpulainen, Jarmo, Pystynen, Tuula, Koskelainen, Patrik, Holm, David, Din Belle
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 77:129005
Here is reported the design and synthesis of a series of highly potent and selective α2C antagonists using benzodioxine methyl piperazine as a central scaffold by pharmacophoric analysis to improve the pharmacokinetics of suboptimal clinical candida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a79817adb5e1c73186ea6f167f3ba422
https://doi.org/10.1016/j.bmcl.2022.129005
https://doi.org/10.1016/j.bmcl.2022.129005
Publikováno v:
Pharmaceuticals, Vol 11, Iss 4, p 117 (2018)
Here, we review the literature assessing the role of transient receptor potential ankyrin 1 (TRPA1), a calcium-permeable non-selective cation channel, in various types of pain conditions. In the nervous system, TRPA1 is expressed in a subpopulation o
Externí odkaz:
https://doaj.org/article/4b1b276dc2c3414c9b5ae3fa41370756
Autor:
Shouming, Wang, Anssi, Haikarainen, Antti, Pohjakallio, Julius, Sipilä, Janne, Kaskinoro, Satu, Juhila, Niina, Jalava, Mikko, Koskinen, Marja, Vesajoki, Esa, Kumpulainen, Jarmo, Pystynen, Tuula, Koskelainen, Patrik, Holm, David, Din Belle
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 69:128783
In this manuscript, we report a series of benzodioxine methyl piperidine derivatives as highly potent and selective α2C antagonists by ligand design to improve the pharmacokinetics of a previous candidate molecule.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d11c0582b9e57eabdf758db92785f82e
https://doi.org/10.1016/j.bmcl.2022.128783
https://doi.org/10.1016/j.bmcl.2022.128783
Autor:
Marta Olszak-Płachta, Mateusz Nowak, Hugh Chapman, Magdalena Sieprawska-Lupa, Raymond Horvath, Klaudia Stefańska, Maciej Mikulski, Marcin Król, Katja Kuokkanen, Michal Galezowski, Mariusz Galek, Niina Jalava, Justyna Adamczyk, Joanna Szeremeta-Spisak, Ullamari Pesonen, Josef Messinger, Harri Salo, Radosław Obuchowicz, Charles-Henry Fabritius, Anna Buda, Peteris Prusis, Timo Korjamo
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:2610-2615
A series of 1-Sulfonyl-6-Piperazinyl-7-Azaindoles, showing strong antagonistic activity to 5-HT6 receptor (5-HT6R) was synthesized and characterized. The series was optimized to reduce activity on D2 receptor. Based on the selectivity against this of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d0e7ddf2aebc8b11e2dc823531d7081
https://doi.org/10.1016/j.bmcl.2016.04.024
https://doi.org/10.1016/j.bmcl.2016.04.024
Publikováno v:
Pharmaceuticals, Vol 11, Iss 4, p 117 (2018)
Pharmaceuticals
Pharmaceuticals
Here, we review the literature assessing the role of transient receptor potential ankyrin 1 (TRPA1), a calcium-permeable non-selective cation channel, in various types of pain conditions. In the nervous system, TRPA1 is expressed in a subpopulation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac862b0a230faa295223d318fac4da5f
https://www.mdpi.com/1424-8247/11/4/117
https://www.mdpi.com/1424-8247/11/4/117
Autor:
Niina Jalava, Timo Korjamo, Ari Koivisto, Ken Lindstedt, Marja Saarnilehto, Hugh Chapman, Antti Pertovaara
Publikováno v:
Basicclinical pharmacologytoxicology. 114(1)
The transient receptor potential ankyrin 1 (TRPA1) ion channel on peripheral terminals of nociceptive primary afferent nerve fibres contributes to the transduction of noxious stimuli to electrical signals, while on central endings in the spinal dorsa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca0e0d15964ac973292aa377d3f0076c
https://pubmed.ncbi.nlm.nih.gov/24102997
https://pubmed.ncbi.nlm.nih.gov/24102997