Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Nihal A. Salem"'
Autor:
Reesha R. Patel, Pauravi Gandhi, Kathryn Spencer, Nihal A. Salem, Chloe. M. Erikson, Vittoria Borgonetti, Roman Vlkolinsky, Larry Rodriguez, Tali Nadav, Michal Bajo, Amanda J. Roberts, R. Dayne Mayfield, Marisa Roberto
Publikováno v:
Neurobiology of Stress, Vol 31, Iss , Pp 100657- (2024)
Chronic ethanol dependence and withdrawal activate corticotropin releasing factor (CRF)-containing GABAergic neurons in the medial prefrontal cortex (mPFC), which tightly regulate glutamatergic pyramidal neurons. Using male CRF1:GFP reporter mice, we
Externí odkaz:
https://doaj.org/article/d2231a05ef614ae7b4944802b1177bc2
Publikováno v:
Neurobiology of Stress, Vol 31, Iss , Pp 100639- (2024)
Toll-like receptors (TLRs) are a family of innate immune receptors that recognize molecular patterns in foreign pathogens and intrinsic danger/damage signals from cells. TLR7 is a nucleic acid sensing endosomal TLR that is activated by single-strande
Externí odkaz:
https://doaj.org/article/552b95dd390742978719e32c396679de
Autor:
Nihal A. Salem, Lawrence Manzano, Michael W. Keist, Olga Ponomareva, Amanda J. Roberts, Marisa Roberto, R. Dayne Mayfield
Publikováno v:
Neurobiology of Disease, Vol 190, Iss , Pp 106361- (2024)
The prefrontal cortex is a crucial regulator of alcohol drinking, and dependence, and other behavioral phenotypes associated with AUD. Comprehensive identification of cell-type specific transcriptomic changes in alcohol dependence will improve our un
Externí odkaz:
https://doaj.org/article/ea029caacbce4f35a16a4a7a7a537be9
Autor:
Dae D. Chung, Amanda H. Mahnke, Marisa R. Pinson, Nihal A. Salem, Michael S. Lai, Natalie P. Collins, Andrew E. Hillhouse, Rajesh C. Miranda
Publikováno v:
Biology of Sex Differences, Vol 14, Iss 1, Pp 1-31 (2023)
Abstract Background Prenatal alcohol (ethanol) exposure (PAE) results in brain growth restriction, in part, by reprogramming self-renewal and maturation of fetal neural stem cells (NSCs) during neurogenesis. We recently showed that ethanol resulted i
Externí odkaz:
https://doaj.org/article/de14ce7b570e4b7eafc5db892721640c
Autor:
Dae D. Chung, Marisa R. Pinson, Amanda H. Mahnke, Nihal A. Salem, Khang T. Le, Elizabeth A. Payne, Tenley E. Lehman, Susan T. Weintraub, Rajesh C. Miranda
Publikováno v:
Heliyon, Vol 8, Iss 11, Pp e11348- (2022)
Accumulating evidence indicates that extracellular vesicles (EVs) mediate endocrine functions and also pathogenic effects of neurodevelopmental perturbagens like ethanol. We performed mass-spectrometry on EVs secreted by fetal murine cerebral cortica
Externí odkaz:
https://doaj.org/article/6d2763162b7e4452a0e52f9d6f1eb21f
Autor:
Amanda H. Mahnke, Georgios D. Sideridis, Nihal A. Salem, Alexander M. Tseng, R. Colin Carter, Neil C. Dodge, Aniruddha B. Rathod, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Rajesh C. Miranda, Joseph L. Jacobson
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-23 (2021)
Abstract Prenatal alcohol exposure (PAE) can result in cognitive and behavioral disabilities and growth deficits. Because alcohol-related neurobehavioral deficits may occur in the absence of overt dysmorphic features or growth deficits, there is a ne
Externí odkaz:
https://doaj.org/article/d5ca958dd8ca40a9a1ee3267343b567a
Autor:
Nihal A. Salem, Amanda H. Mahnke, Alan B. Wells, Alexander M. Tseng, Lyubov Yevtushok, Natalya Zymak-Zakutnya, Wladimir Wertlecki, Christina D. Chambers, Rajesh C. Miranda, Collaborative Initiative on Fetal Alcohol Spectrum Disorders (CIFASD)
Publikováno v:
Biology of Sex Differences, Vol 11, Iss 1, Pp 1-17 (2020)
Abstract Most persons with fetal alcohol spectrum disorders (FASDs) remain undiagnosed or are diagnosed in later life. To address the need for earlier diagnosis, we previously assessed miRNAs in the blood plasma of pregnant women who were classified
Externí odkaz:
https://doaj.org/article/f02315f86070432eb69f640876acc9e6
Publikováno v:
iScience, Vol 24, Iss 5, Pp 102439- (2021)
Summary: Prenatal alcohol exposure (PAE) results in cerebral cortical dysgenesis. Single-cell RNA sequencing was performed on murine fetal cerebral cortical cells from six timed pregnancies, to decipher persistent cell- and sex-specific effects of an
Externí odkaz:
https://doaj.org/article/fd016063bd4242c48884827bf96a5cb6
Autor:
Laura B. Ferguson, Yi-Pei Chen, George Zheng, Nihal A Salem, Mohammed Eslami, R. Dayne Mayfield
Publikováno v:
Bioinformatics
Motivation Transcriptomics is a common approach to identify changes in gene expression induced by a disease state. Standard transcriptomic analyses consider differentially expressed genes (DEGs) as indicative of disease states so only a few genes wou
Publikováno v:
Pharmacol Biochem Behav