Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Nigulas Samel"'
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0185291 (2017)
Two highly identical fusion proteins, an allene oxide synthase-lipoxygenase (AOS-LOX) and a hydroperoxide lyase-lipoxygenase (HPL-LOX), were identified in the soft coral Capnella imbricata. Both enzymes initially catalyze the formation of 8R-hydroper
Externí odkaz:
https://doaj.org/article/a72b5950c9184a5fac08a13127bd8682
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89215 (2014)
In octocorals, a catalase-like allene oxide synthase (AOS) and an 8R-lipoxygenase (LOX) gene are fused together encoding for a single AOS-LOX fusion protein. Although the AOS-LOX pathway is central to the arachidonate metabolism in corals, its biolog
Externí odkaz:
https://doaj.org/article/fb98a6f8d3d640a2a89e5a1f557d28ff
Publikováno v:
Biochemical and Biophysical Research Communications. 519:81-85
Lipoxygenases (LOXs) are dioxygenases that catalyze the oxygenation of polyunsaturated fatty acids to hydroperoxyl derivates. These products are precursors for different lipid mediators which are associated with pathogenesis of various diseases such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b4222d5b1f7d7e7bfd44bcda60991d0
https://doi.org/10.1016/j.bbrc.2019.08.132
https://doi.org/10.1016/j.bbrc.2019.08.132
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1862:1121-1128
Lipoxygenases (LOXs), participating in inflammatory processes and cancer, are a family of enzymes with high potential as drug targets. Various allosteric effects have been observed with different LOX isozymes (e.g. lipid/ATP binding, phosphorylation)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df0ff62a6c03501585e31a9bd86ea582
https://doi.org/10.1016/j.bbalip.2017.07.012
https://doi.org/10.1016/j.bbalip.2017.07.012
Publikováno v:
Archives of biochemistry and biophysics. 676
A catalase-related allene oxide synthase (cAOS) or a hydroperoxide lyase (cHPL) fused together with an 8R-lipoxygenase is involved in the stress signaling of corals via an arachidonic acid pathway. cAOS gives rise to α-ketol and cyclopentenone, whil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::290171e65d95e7bb57edd6ff5a5b77a6
https://pubmed.ncbi.nlm.nih.gov/31589830
https://pubmed.ncbi.nlm.nih.gov/31589830
Autor:
Nigulas Samel, Kaia Kukk
Publikováno v:
Journal of Biotechnology. 231:224-231
Vertebrate prostaglandin H synthases (PGHSs) are membrane-bound disulphide-containing hemoglycoproteins. Therefore, eukaryotic expression systems are required for the production of recombinant PGHSs. Recently we announced the expression of human PGHS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::563afaf4b5ec8f2161dfb71bda768a6b
https://doi.org/10.1016/j.jbiotec.2016.06.015
https://doi.org/10.1016/j.jbiotec.2016.06.015
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1865:158553
Pancreatic lipase (PNLIP) is a digestive enzyme that is a potential drug target for the treatment of obesity. A better understanding of its regulation mechanisms would facilitate the development of new therapeutics. Recent studies indicate that intes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ac0968649e84de9735195521ac213b5
https://doi.org/10.1016/j.bbalip.2019.158553
https://doi.org/10.1016/j.bbalip.2019.158553
Autor:
Alan R. Brash, Nigulas Samel, Tarvi Teder, Wade M. Calcutt, William E. Boeglin, Helike Lõhelaid
Publikováno v:
Journal of Biological Chemistry. 290:19823-19832
In corals a catalase-lipoxygenase fusion protein transforms arachidonic acid to the allene oxide 8R,9-epoxy-5,9,11,14-eicosatetraenoic acid from which arise cyclopentenones such as the prostanoid-related clavulones. Recently we cloned two catalase-li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3cad3409b708df3d28c5f69fb6304366
https://doi.org/10.1074/jbc.m115.660282
https://doi.org/10.1074/jbc.m115.660282
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0185291 (2017)
PLoS ONE
PLoS ONE
Two highly identical fusion proteins, an allene oxide synthase-lipoxygenase (AOS-LOX) and a hydroperoxide lyase-lipoxygenase (HPL-LOX), were identified in the soft coral Capnella imbricata. Both enzymes initially catalyze the formation of 8R-hydroper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df2605fd9e8d930b225ac06b9720ff11
http://europepmc.org/articles/PMC5617202?pdf=render
http://europepmc.org/articles/PMC5617202?pdf=render
Publikováno v:
Coral Reefs. 34:143-154
Marine ecosystems are sensitive to elevated seawater temperature, with stony corals serving as model organisms for temperature-imposed declines in population viability and diversity. Several stress markers, including heat shock proteins, have been us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66c1a89456f1cee33276b7fff928d068
https://doi.org/10.1007/s00338-014-1238-y
https://doi.org/10.1007/s00338-014-1238-y