Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Nigel Whittle"'
Autor:
Nigel Whittle, Jonathan Fadok, Kathryn P. MacPherson, Robin Nguyen, Paolo Botta, Steffen B. E. Wolff, Christian Müller, Cyril Herry, Philip Tovote, Andrew Holmes, Nicolas Singewald, Andreas Lüthi, Stéphane Ciocchi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
The central amygdala inhibitory microcircuits mediate fear extinction by reversible, stimulus- and context-specific changes in neuronal responses. These alterations are absent when extinction is deficient and selective silencing of PKCδ neurons impa
Externí odkaz:
https://doaj.org/article/e7f5a40092e743959f493ea9a98ded5d
Autor:
Clemens Jaitner, Chethan Reddy, Andreas Abentung, Nigel Whittle, Dietmar Rieder, Andrea Delekate, Martin Korte, Gaurav Jain, Andre Fischer, Farahnaz Sananbenesi, Isabella Cera, Nicolas Singewald, Georg Dechant, Galina Apostolova
Publikováno v:
eLife, Vol 5 (2016)
SATB2 is a risk locus for schizophrenia and encodes a DNA-binding protein that regulates higher-order chromatin configuration. In the adult brain Satb2 is almost exclusively expressed in pyramidal neurons of two brain regions important for memory for
Externí odkaz:
https://doaj.org/article/3ef5e8fc74a14c26a3f979b4746b720c
Autor:
Maria Kharitonova, Rainer Landgraf, Rebekka P. Diepold, Anupam Sah, Claudia Schmuckermair, S. V. Sotnikov, Nigel Whittle, Nicolas Singewald
Publikováno v:
International Journal of Neuropsychopharmacology
Background Pathological anxiety originates from a complex interplay of genetic predisposition and environmental factors, acting via epigenetic mechanisms. Epigenetic processes that can counteract detrimental genetic risk towards innate high anxiety a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3801db1c070fe4c7a8512ea77866bbcd
https://doi.org/10.1093/ijnp/pyz004
https://doi.org/10.1093/ijnp/pyz004
Autor:
Nigel Whittle
Publikováno v:
Cell and Gene Therapy Insights. 3:329-333
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1a6062623cc1ef8962d0a6fc3265a01
https://doi.org/10.18609/cgti.2017.010
https://doi.org/10.18609/cgti.2017.010
Autor:
Nigel Whittle, Shaun Flynn, Paul J. Fitzgerald, Nicolas Singewald, Alexxai V. Kravitz, Courtney R. Pinard, Ozge Gunduz-Cinar, Andrew Holmes, Carolyn Graybeal
Publikováno v:
Neurobiology of Learning and Memory. 113:69-81
The neural circuitry mediating fear extinction has been increasingly well studied and delineated. The rodent infralimbic subregion (IL) of the ventromedial prefrontal cortex (vmPFC) has been found to promote extinction, whereas the prelimbic cortex (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69569ab9eb5243cd1bbb36de37f8c89b
https://doi.org/10.1016/j.nlm.2013.11.002
https://doi.org/10.1016/j.nlm.2013.11.002
Autor:
Andreas Abentung, Gaurav Jain, Martin Korte, Farahnaz Sananbenesi, Georg Dechant, Dietmar Rieder, Galina Apostolova, Isabella Cera, Clemens Jaitner, Nicolas Singewald, Andre Fischer, Nigel Whittle, Andrea Delekate, Chethan Reddy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d65f21f351e08d490341645ee847b8e7
https://doi.org/10.7554/elife.17361.040
https://doi.org/10.7554/elife.17361.040
Autor:
Conor P, Murphy, Xiang, Li, Verena, Maurer, Michael, Oberhauser, Ronald, Gstir, Luis Eduardo, Wearick-Silva, Thiago Wendt, Viola, Simon, Schafferer, Rodrigo, Grassi-Oliveira, Nigel, Whittle, Alexander, Hüttenhofer, Timothy W, Bredy, Nicolas, Singewald
Publikováno v:
Biological psychiatry. 81(12)
MicroRNA (miRNA)-mediated control of gene expression suggests that miRNAs are interesting targets and/or biomarkers in the treatment of anxiety- and trauma-related disorders, where often memory-associated gene expression is adversely affected.The rol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::047039f12977741f8238d926b6a3c055
https://pubmed.ncbi.nlm.nih.gov/28554392
https://pubmed.ncbi.nlm.nih.gov/28554392
Autor:
Andreas Abentung, Nigel Whittle, Georg Dechant, Andre Fischer, Nicolas Singewald, Dietmar Rieder, Gaurav Jain, Chethan Reddy, Martin Korte, Galina Apostolova, Isabella Cera, Farahnaz Sananbenesi, Clemens Jaitner, Andrea Delekate
Publikováno v:
eLife 5, e17361 (2016). doi:10.7554/eLife.17361
eLife, Vol 5 (2016)
eLife
eLife, Vol 5 (2016)
eLife
SATB2 is a risk locus for schizophrenia and encodes a DNA-binding protein that regulates higher-order chromatin configuration. In the adult brain Satb2 is almost exclusively expressed in pyramidal neurons of two brain regions important for memory for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f64a005f2183b34fe1ecb03903c0caea
Publikováno v:
Neuropharmacology
Preclinical and some clinical studies suggest a relationship between perturbation in magnesium (Mg2+) homeostasis and pathological anxiety, although the underlying mechanisms remain largely unknown. Since there is evidence that Mg2+ modulates the hyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b25fcd8e75af366b81519ab7688d2dd7
https://doi.org/10.1016/j.neuropharm.2011.07.027
https://doi.org/10.1016/j.neuropharm.2011.07.027
Autor:
Conor P. Murphy, Nicolas Singewald, Claudia Schmuckermair, Verena Maurer, Nigel Whittle, Simone B. Sartori, Patrick Muigg, Inga D. Neumann
Publikováno v:
International Journal of Neuropsychopharmacology
Background: Despite its success in treating specific anxiety disorders, the effect of exposure therapy is limited by problems with tolerability, treatment resistance, and fear relapse after initial response. The identification of novel drug targets f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d2ba1b634e6ae51d65b4072b8c171fa
http://europepmc.org/articles/PMC4926792
http://europepmc.org/articles/PMC4926792