Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Nigel Whitebread"'
Autor:
Marisa O Peluso, Veronica T Campbell, Joseph A Harari, Thomas T Tibbitts, Jennifer L Proctor, Nigel Whitebread, James M Conley, Kerry F White, Jeffery L Kutok, Margaret A Read, Karen McGovern, Kerrie L Faia
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90534 (2014)
A requisite step for canonical Hedgehog (Hh) pathway activation by Sonic Hedgehog (Shh) ligand is accumulation of Smoothened (Smo) to the primary cilium (PC). Activation of the Hh pathway has been implicated in a broad range of cancers, and several S
Externí odkaz:
https://doaj.org/article/b3435ef7823e4fa0b69c0b4bca9c80e8
Autor:
Joi Dunbar, Margaret A. Read, Joseph D. Manna, Alexander Constan, Alfredo C. Castro, Sherri Smith, Gordon Loewen, John Lee, Somarajan J. Nair, Jennifer Hoyt, Martin R. Tremblay, Julian Adams, Jeanne A. Ferguson, Jens Sydor, Veronica Campbell, Matthew Campbell, Karen McGovern, Brendan Arsenault, Marisa O. Peluso, Jylle Nevejans, Vito J. Palombella, Nigel Whitebread, Grogan Michael John, Kerrie Faia, John Soglia, Bennett Carter
Publikováno v:
Xenobiotica. 43:875-885
1. IPI-926 is a novel semisynthetic cyclopamine derivative that is a potent and selective Smoothened inhibitor that blocks the hedgehog signal transduction pathway. 2. The in vivo clearance of IPI-926 is low in mouse and dog and moderate in monkey. T
Autor:
John Coco, Christian C. Fritz, Kip A. West, Emmanuel Normant, Vito J. Palombella, John Macdougall, Nigel Whitebread, Bonnie Tillotson, Jie Ge, Kelly Slocum, Brian Thomas, Janid A. Ali, Julian Adams
Publikováno v:
The Journal of Biological Chemistry
Several Hsp90 (heat shock protein 90) inhibitors are currently under clinical evaluation as anticancer agents. However, the correlation between the duration and magnitude of Hsp90 inhibition and the downstream effects on client protein degradation an
Autor:
James M. Conley, Karen McGovern, Jeffery L. Kutok, Kerry White, Kerrie Faia, Margaret A. Read, Marisa O. Peluso, Joseph A. Harari, Nigel Whitebread, Thomas T. Tibbitts, Veronica Campbell, Jennifer Proctor
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 3, p e90534 (2014)
PLoS ONE, Vol 9, Iss 3, p e90534 (2014)
A requisite step for canonical Hedgehog (Hh) pathway activation by Sonic Hedgehog (Shh) ligand is accumulation of Smoothened (Smo) to the primary cilium (PC). Activation of the Hh pathway has been implicated in a broad range of cancers, and several S
Autor:
Sunil R. Hingorani, Kristopher K. Frese, Alex R. Chang, Christine Feig, Davina J. Honess, Christine A. Iacobuzio-Donahue, Ralph H. Hruban, Basetti Madhu, Christian Pilarsky, Michael A. Jacobetz, Gina M. DeNicola, Karen McGovern, Stephen P. Winter, Felix Rückert, David A. Tuveson, Mae A. Goldgraben, Mousumi Dhara, Dominick J.O. McIntyre, William Plunkett, Aarthi Gopinathan, Julian Adams, David Allard, Pearl S. Huang, Christian Davidson, Robert Grützmann, Susan E. Davies, Stefanie Reichelt, John R. Griffiths, Lifu Wang, Nigel Whitebread, Kamel Izeradjene, William J. Howat, Chelsea Combs, Kenneth P. Olive, Meredith E. Caldwell, Heather Ireland-Zecchini, Merrill J. Egorin
It's All in the Delivery Pancreatic cancer is almost universally associated with a poor prognosis, in part because the tumors are resistant to chemotherapeutic drugs. Working with a mouse tumor model that displays many features of the human disease,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54cfcf476fa43282aa0964ca2f461194
https://europepmc.org/articles/PMC2998180/
https://europepmc.org/articles/PMC2998180/
Autor:
Aarthi Gopinathan, Heather Ireland, Kenneth P. Olive, Christine A. Iacobuzio-Donahue, Michael A. Jacobetz, David A. Tuveson, Stefanie Reichelt, Julian Adams, John R. Griffiths, Mae A. Goldgraben, William J. Howat, Nigel Whitebread, Karen McGovern
Publikováno v:
Clinical Cancer Research. 16:PR2-PR2
Ductal pancreatic tumors are unusually resistant to chemotherapy, exhibiting primary resistance to each of the numerous regimens tested to date. These tumors are also unusually desmoplastic and harbor a sparse and inefficient vasculature. The resulti